Distinct Effects of Zn 2 + , Cu 2 + , Fe 3 + , and Al 3 + on Amyloid-β Stability , Oligomerization , and Aggregation : Amyloid-β Destabilization Promotes Annular Protofibril Formation

Aggregation: Amyloid-β Destabilization Promotes Annular Protofibril Formation Wei-Ting Chen, Yi-Hung Liao, Hui-Ming Yu, Irene H. Cheng, and Yun-Ru Chen From Genomics Research Center, Academia Sinica, Institute of Brain Science, National Yang-Ming University, Taiwan International Graduate Program, Chemical Biology and Molecular Biophysics Program, Genomics Research Center, Academia Sinica, Institute of Biochemical Sciences, National Taiwan University, Taiwan Running head: Distinct metal ion effects on Aβ folding and aggregation *Address correspondence to: Yun-Ru Chen, Genomics Research Center, Academia Sinica, Taiwan. 128, Academia Road, Sec. 2, Nankang Dist., Taipei 115, Taiwan. Tel. 886-2-2787-1275; Fax. 886-2-2789-8771; E-Mail: yrchen@gate.sinica.edu.tw