Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis.

[1]  B. Prabhakar,et al.  Control of mitochondrial activity by miRNAs , 2012, Journal of cellular biochemistry.

[2]  Min Wu,et al.  Bioenergetic profile experiment using C2C12 myoblast cells. , 2010, Journal of visualized experiments : JoVE.

[3]  C. Zechner,et al.  Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. , 2010, Cell metabolism.

[4]  C. Frei,et al.  Mitochondria in response to nutrients and nutrient-sensitive pathways. , 2010, Mitochondrion.

[5]  N. Pfanner,et al.  Mitochondrial protein import: from proteomics to functional mechanisms , 2010, Nature Reviews Molecular Cell Biology.

[6]  S. Guan,et al.  Analysis of proteome dynamics in the mouse brain , 2010, Proceedings of the National Academy of Sciences.

[7]  D. Richardson,et al.  Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol , 2010, Proceedings of the National Academy of Sciences.

[8]  J. Kaplan,et al.  Specific iron chelators determine the route of ferritin degradation. , 2009, Blood.

[9]  R. Lill.  Function and biogenesis of iron–sulphur proteins , 2009, Nature.

[10]  V. Mootha,et al.  Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans , 2009, Proceedings of the National Academy of Sciences.

[11]  E. McLean,et al.  Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005 , 2009, Public Health Nutrition.

[12]  Anastasia Kralli,et al.  Transcriptional control of mitochondrial biogenesis and function. , 2009, Annual review of physiology.

[13]  Eduardo Ruiz-Pesini,et al.  Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease. , 2008, Human molecular genetics.

[14]  S. Carr,et al.  A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology , 2008, Cell.

[15]  R. Scarpulla.  Transcriptional paradigms in mammalian mitochondrial biogenesis and function. , 2008, Physiological reviews.

[16]  D. Richardson,et al.  Tuning Cell Cycle Regulation with an Iron Key , 2007, Cell cycle.

[17]  G. Semenza,et al.  HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. , 2007, Cancer cell.

[18]  M. Mann,et al.  A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC) , 2006, Nature Protocols.

[19]  Young-sil Yoon,et al.  Formation of elongated giant mitochondria in DFO‐induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1 , 2006, Journal of cellular physiology.

[20]  Jiandie D. Lin,et al.  Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. , 2006, Cell metabolism.

[21]  D. Wallace.  A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine , 2005, Annual review of genetics.

[22]  B. Lowell,et al.  Mitochondrial Dysfunction and Type 2 Diabetes , 2005, Science.

[23]  J. Marín-García,et al.  Mitochondrial signaling pathways: A receiver/integrator organelle , 2004, Molecular and Cellular Biochemistry.

[24]  Christopher J. Schofield,et al.  Oxygen sensing by HIF hydroxylases , 2004, Nature Reviews Molecular Cell Biology.

[25]  Marjan S. Bolouri,et al.  Integrated Analysis of Protein Composition, Tissue Diversity, and Gene Regulation in Mouse Mitochondria , 2003, Cell.

[26]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[27]  D. Richardson,et al.  Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity , 2003, American journal of hematology.

[28]  S. Dimauro,et al.  Mitochondrial respiratory-chain diseases. , 2003, The New England journal of medicine.

[29]  R. Eisenstein,et al.  Novel roles for iron regulatory proteins in the adaptive response to iron deficiency. , 2003, The Journal of nutrition.

[30]  M. Thevis,et al.  In-gel derivatization of proteins for cysteine-specific cleavages and their analysis by mass spectrometry. , 2003, Journal of proteome research.

[31]  M. Mann,et al.  Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics* , 2002, Molecular & Cellular Proteomics.

[32]  D. Kressler,et al.  The PGC-1-related Protein PERC Is a Selective Coactivator of Estrogen Receptor α* , 2002, The Journal of Biological Chemistry.

[33]  Jiandie D. Lin,et al.  Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor* , 2002, The Journal of Biological Chemistry.

[34]  R. Scarpulla,et al.  PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells , 2001, Molecular and Cellular Biology.

[35]  Michael I. Wilson,et al.  Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.

[36]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[37]  P. Puigserver,et al.  A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.

[38]  W. Kueng,et al.  Quantification of cells cultured on 96-well plates. , 1989, Analytical biochemistry.

[39]  V. Mootha,et al.  The mitochondrial proteome and human disease. , 2010, Annual review of genomics and human genetics.

[40]  Thomas D. Fox,et al.  Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation , 2010, Nature Reviews Molecular Cell Biology.

[41]  R. Youle,et al.  Mechanisms of mitophagy , 2010, Nature Reviews Molecular Cell Biology.

[42]  M. Mann,et al.  Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips , 2007, Nature Protocols.

[43]  Matthias W. Hentze,et al.  Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization , 2004 .

[44]  Jiandie D. Lin,et al.  Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. , 2002, The Journal of biological chemistry.