A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth

[1]  Jie Chen,et al.  A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth , 2012, Journal of Experimental & Clinical Cancer Research.

[2]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[3]  Wael A Sakr,et al.  Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy. , 2010, Current drug targets.

[4]  Zhiwei Wang,et al.  Down‐regulation of uPA and uPAR by 3,3′‐diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells , 2009, Journal of cellular biochemistry.

[5]  G. Firestone,et al.  3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. , 2009, Biochemical pharmacology.

[6]  J. Park,et al.  Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells , 2009, BMC gastroenterology.

[7]  Jie Chen,et al.  Potential therapeutic significance of increased expression of aryl hydrocarbon receptor in human gastric cancer. , 2009, World journal of gastroenterology.

[8]  Richard E. Peterson,et al.  The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. , 2009, Biochemical pharmacology.

[9]  Han Chang,et al.  Overexpression of cytochrome P450 1B1 in advanced non-small cell lung cancer: a potential therapeutic target. , 2009, Anticancer research.

[10]  T. Gasiewicz,et al.  Expression and activity of aryl hydrocarbon receptors in development and cancer. , 2008, Critical reviews in eukaryotic gene expression.

[11]  X. Coumoul,et al.  The aryl hydrocarbon receptor, more than a xenobiotic‐interacting protein , 2007, FEBS letters.

[12]  Y. Surh,et al.  Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. , 2007, The Journal of nutrition.

[13]  Zhiwei Wang,et al.  Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. , 2007, Molecular cancer therapeutics.

[14]  P. García Alfonso,et al.  Management of gastric adenocarcinoma , 2007, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.

[15]  S. Kitamura,et al.  Comparative study of aryl hydrocarbon receptor ligand activities of six chemicals in vitro and in vivo , 2007, Archives of Toxicology.

[16]  D. Seldin,et al.  A role for the aryl hydrocarbon receptor in mammary gland tumorigenesis , 2006, Biological chemistry.

[17]  Zhiwei Wang,et al.  Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. , 2006, Cancer research.

[18]  P. Mandal Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology , 2005, Journal of Comparative Physiology B.

[19]  Yiwei Li,et al.  Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. , 2005, Frontiers in bioscience : a journal and virtual library.

[20]  P. Malfertheiner,et al.  Recent Advances in Molecular Diagnosis and Therapy of Gastric Cancer , 2005, Digestive Diseases.

[21]  D. Trichopoulos,et al.  Dioxin and cancer: a critical review. , 2003, Regulatory toxicology and pharmacology : RTP.

[22]  J. Xu,et al.  Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene , 2003, Journal of applied toxicology : JAT.

[23]  R. Pollenz The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation. , 2002, Chemico-biological interactions.

[24]  H. Friess,et al.  Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer , 2002, Oncogene.

[25]  G. Firestone,et al.  3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. , 2002, Carcinogenesis.

[26]  S. Safe,et al.  Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). , 2002, International journal of oncology.

[27]  S. Safe,et al.  Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. , 2001, Biochemical pharmacology.

[28]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[29]  H. Ciolino,et al.  Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. , 1998, Cancer research.

[30]  S. Safe,et al.  Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. , 1998, Carcinogenesis.

[31]  S. Safe,et al.  Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. , 1996, Biochemical pharmacology.

[32]  V. Vasiliou,et al.  Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a , 1993, Annals of the New York Academy of Sciences.

[33]  A. Okey,et al.  Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. , 1993, Biochemical pharmacology.

[34]  L. Bjeldanes,et al.  Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism. , 1987, Journal of toxicology and environmental health.