Rough mutants defective in core and O-polysaccharide synthesis and export induce antibodies reacting in an indirect ELISA with smooth lipopolysaccharide and are less effective than Rev 1 vaccine against Brucella melitensis infection of sheep.

[1]  A. Weintraub,et al.  Brucellosis Vaccines: Assessment of Brucella melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-Polysaccharide Synthesis and Export , 2008, PloS one.

[2]  R. Ugalde,et al.  Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1 , 2008, PLoS pathogens.

[3]  E. J. Young,et al.  Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations , 2007, PLoS medicine.

[4]  A. Gross,et al.  Interaction of Brucella suis and Brucella abortus Rough Strains with Human Dendritic Cells , 2007, Infection and Immunity.

[5]  S. Hagius,et al.  Identification of Brucella melitensis 16M genes required for bacterial survival in the caprine host. , 2006, Microbes and infection.

[6]  J. Letesson,et al.  FtcR Is a New Master Regulator of the Flagellar System of Brucella melitensis 16M with Homologs in Rhizobiaceae , 2006, Journal of bacteriology.

[7]  C. Seabury,et al.  Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis. , 2006, Vaccine.

[8]  I. Moriyón,et al.  Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutants. , 2006, Vaccine.

[9]  A. Benkirane.  Ovine and caprine brucellosis: World distribution and control/eradication strategies in West Asia/North Africa region , 2006 .

[10]  Georgios Pappas,et al.  The new global map of human brucellosis. , 2006, The Lancet. Infectious diseases.

[11]  A. Gross,et al.  High Susceptibility of Human Dendritic Cells to Invasion by the Intracellular Pathogens Brucella suis, B. abortus, and B. melitensis , 2005, Infection and Immunity.

[12]  G. Splitter,et al.  Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infections , 2005, Cellular microbiology.

[13]  A. Cloeckaert,et al.  Development and evaluation as vaccines in mice of Brucella melitensis Rev.1 single and double deletion mutants of the bp26 and omp31 genes coding for antigens of diagnostic significance in ovine brucellosis. , 2004, Vaccine.

[14]  J. Gorvel,et al.  Intracellular trafficking study of a RB51 B. abortus vaccinal strain isolated from cow milk. , 2004, Veterinary microbiology.

[15]  I. Moriyón,et al.  Characterization of Brucella abortus O-Polysaccharide and Core Lipopolysaccharide Mutants and Demonstration that a Complete Core Is Required for Rough Vaccines To Be Efficient against Brucella abortus and Brucella ovis in the Mouse Model , 2003, Infection and Immunity.

[16]  T. Hadfield,et al.  Interactions between Brucella melitensis and Human Phagocytes: Bacterial Surface O-Polysaccharide Inhibits Phagocytosis, Bacterial Killing, and Subsequent Host Cell Apoptosis , 2003, Infection and Immunity.

[17]  J. Paquet,et al.  Major outer membrane proteins of Brucella spp.: past, present and future. , 2002, Veterinary microbiology.

[18]  Nammalwar Sriranganathan,et al.  Brucellosis vaccines: past, present and future. , 2002, Veterinary microbiology.

[19]  E. Moreno,et al.  Brucella intracellular life: from invasion to intracellular replication. , 2002, Veterinary microbiology.

[20]  A. Benkirane,et al.  Comparison of the efficacy of Brucella abortus strain RB51 and Brucella melitensis Rev. 1 live vaccines against experimental infection with Brucella melitensis in pregnant ewes. , 2001, Revue scientifique et technique.

[21]  D. O’Callaghan,et al.  Identification of Brucella suis Genes Affecting Intracellular Survival in an In Vitro Human Macrophage Infection Model by Signature-Tagged Transposon Mutagenesis , 2000, Infection and Immunity.

[22]  R. Díaz,et al.  Evaluation of Lipopolysaccharides and Polysaccharides of Different Epitopic Structures in the Indirect Enzyme-Linked Immunosorbent Assay for Diagnosis of Brucellosis in Small Ruminants and Cattle , 1998, Clinical Diagnostic Laboratory Immunology.

[23]  I. Moriyón,et al.  Comparison of polyclonal, monoclonal and protein G peroxidase conjugates in an enzyme-linked immunosorbent assay for the diagnosis of Brucella ovis in sheep , 1998, Veterinary Record.

[24]  B. Garin‐Bastuji,et al.  Brucella melitensis infection in sheep: present and future. , 1998, Veterinary research.

[25]  G. Schurig,et al.  Evaluation of a rough mutant of Brucella melitensis in pregnant goats. , 1998, Research in veterinary science.

[26]  T. Ficht,et al.  Transposon-Derived Brucella abortusRough Mutants Are Attenuated and Exhibit Reduced Intracellular Survival , 1998, Infection and Immunity.

[27]  J. Blasco,et al.  A review of the use of B. melitensis Rev 1 vaccine in adult sheep and goats. , 1997, Preventive veterinary medicine.

[28]  G. Schurig,et al.  Protection of BALB/c mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitensis and Brucella suis biovar 4. , 1996, American journal of veterinary research.

[29]  J. Blasco,et al.  Comparison of two selective media for the isolation of Brucella melitensis from naturally infected sheep and goats , 1996, Veterinary Record.

[30]  I. Moriyón,et al.  Diagnosis of Brucella ovis infection of rams with an ELISA using protein G as conjugate , 1995, Veterinary Record.

[31]  B. Garin‐Bastuji,et al.  Efficacy of different Rose Bengal and complement fixation antigens for the diagnosis of Brucella melitensis infection in sheep and goats , 1994, Veterinary Record.

[32]  C. Gamazo,et al.  Protective immunity to Brucella ovis in BALB/c mice following recovery from primary infection or immunization with subcellular vaccines , 1994, Infection and immunity.

[33]  L. Araya,et al.  Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum , 1990, Infection and immunity.

[34]  A. M. Wu,et al.  Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies , 1986, Infection and immunity.

[35]  B. Cunningham.  Protective effects of colostral antibodies to Br abortus on strain 19 vaccination and field injection , 1977, Veterinary Record.

[36]  C. Galanos,et al.  A new method for the extraction of R lipopolysaccharides. , 1969, European journal of biochemistry.

[37]  D. Morelli,et al.  Zoonoses in the Mediterranean region. , 2006, Annali dell'Istituto superiore di sanita.

[38]  E. Moreno,et al.  Rough vaccines in animal brucellosis: structural and genetic basis and present status. , 2004, Veterinary research.

[39]  R. Saenz,et al.  Reporte de primer caso humano de aislamiento y tipificación de Brucella abortus RB 51 , 2000 .

[40]  J. Blasco,et al.  The Brucella abortus RB51 vaccine does not confer protection against Brucella ovis in rams. , 1995, Vaccine.

[41]  M. Grayon,et al.  Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis Rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewes. , 1995, Vaccine.

[42]  J. Verger,et al.  Techniques for the Brucellosis Laboratory , 1988 .

[43]  M. Plommet,et al.  Immunity conferred upon mice by anti-LPS monoclonal antibodies in murine brucellosis. , 1987, Annales de l'Institut Pasteur. Immunology.

[44]  M. Plommet,et al.  L'immunité anti-Brucella transférée par sérum immun et l'immunité transférée par les lymphocytes spléniques ne s'additionnenet pas , 1986 .

[45]  A. Ardalan,et al.  COMPARISON OF LIVING VACCINES IN PRODUCING IMMUNITY AGAINST NATURAL BRUCELLA MELITENSIS INFECTION IN SHEEP AND GOATS IN IRAN. , 1964, Journal of comparative pathology.

[46]  W. Spink.  The Nature of Brucellosis , 1956 .