TOWARDS AUTOMATIC EPILEPTIC SEIZURE DETECTION IN EEGS BASED ON NEURAL NETWORKS AND LARGEST LYAPUNOV EXPONENT

Over the past few decades, application of neural networks and chaos theory to electroencephalogram (EEG) analysis has grown rapidly due to the complex and nonlinear nature of EEG data. We report a novel method for epileptic seizure detection that is depending on the maximal short-term Lyapunov exponent (STLmax). The proposed approach is based on the automatic segmentation of the EEG into time segments that correspond to epileptic and non-epileptic activity. The STL-max is then computed from both categories of EEG signal and used for classification of epileptic and non-epileptic EEG segments throughout the recording. Neural network techniques are proposed both for segmentation of EEG signals and computation of STLmax. The data set from hospital have been used for experiments performing. It consists of 21 records during 8 seconds of eight adult patients. Furthermore the publicly available data were used for experiments. The main advantages of presented neural technique is its ability to detect rapidly the small EEG time segments as the epileptic or non-epileptic activity, training without desired data set about epileptic and non-epileptic activity in EEG signals. The proposed approach permits to detect exactly the epileptic and non-epileptic EEG segments of different duration and shape in order to identify a pathological activity in a remission state as well as detect a paroxysmal activity in a preictal period.

[1]  P. Pardalos,et al.  Performance of a seizure warning algorithm based on the dynamics of intracranial EEG , 2005, Epilepsy Research.

[2]  K. Lehnertz,et al.  The epileptic process as nonlinear deterministic dynamics in a stochastic environment: an evaluation on mesial temporal lobe epilepsy , 2001, Epilepsy Research.

[3]  Lalit M. Patnaik,et al.  Epileptic EEG detection using neural networks and post-classification , 2008, Comput. Methods Programs Biomed..

[4]  Metin Akay,et al.  Measurement and Quantification of Spatiotemporal Dynamics of Human Epileptic Seizures , 2000 .

[5]  Jesse Gilbert,et al.  Analysis: Theory and Practice , 2013 .

[6]  Daniel Rivero,et al.  Epileptic seizure detection using multiwavelet transform based approximate entropy and artificial neural networks , 2010, Journal of Neuroscience Methods.

[7]  Kemal Polat,et al.  Classification of epileptiform EEG using a hybrid system based on decision tree classifier and fast Fourier transform , 2007, Appl. Math. Comput..

[8]  Guang H. Yue,et al.  Nonlinear features of surface EEG showing systematic brain signal adaptations with muscle force and fatigue , 2009, Brain Research.

[9]  Abdulhamit Subasi Automatic detection of epileptic seizure using dynamic fuzzy neural networks , 2006, Expert Syst. Appl..

[10]  Nadia Mammone,et al.  Visualization and modelling of STLmax topographic brain activity maps , 2010, Journal of Neuroscience Methods.

[11]  V. Golovko,et al.  Neural Networks for Signal Processing in Measurement Analysis and Industrial Applications : the Case of Chaotic Signal Processing , 2002 .

[12]  F. Takens Detecting strange attractors in turbulence , 1981 .

[13]  Daniel Rivero,et al.  Automatic epileptic seizure detection in EEGs based on line length feature and artificial neural networks , 2010, Journal of Neuroscience Methods.

[14]  H. Kantz A robust method to estimate the maximal Lyapunov exponent of a time series , 1994 .

[15]  A. Wolf,et al.  Determining Lyapunov exponents from a time series , 1985 .

[16]  Abdulhamit Subasi,et al.  Application of adaptive neuro-fuzzy inference system for epileptic seizure detection using wavelet feature extraction , 2007, Comput. Biol. Medicine.

[17]  Paulo J. G. Lisboa,et al.  The Use of Artificial Neural Networks in Decision Support in Cancer: a Systematic Review , 2005 .

[18]  Xingyuan Wang,et al.  Research on the relation of EEG signal chaos characteristics with high-level intelligence activity of human brain , 2010, Nonlinear biomedical physics.

[19]  P. Pardalos,et al.  An investigation of EEG dynamics in an animal model of temporal lobe epilepsy using the maximum Lyapunov exponent , 2009, Experimental Neurology.

[20]  M. Rosenstein,et al.  A practical method for calculating largest Lyapunov exponents from small data sets , 1993 .

[21]  F. L. D. Silva,et al.  EEG analysis: Theory and Practice , 1998 .

[22]  Ali H. Shoeb,et al.  Application of Machine Learning To Epileptic Seizure Detection , 2010, ICML.

[23]  Daniel Graupe,et al.  A neural-network-based detection of epilepsy , 2004, Neurological research.

[24]  Erkki Oja,et al.  Independent component analysis: algorithms and applications , 2000, Neural Networks.

[25]  Sung-Nien Yu,et al.  Detection of seizures in EEG using subband nonlinear parameters and genetic algorithm , 2010, Comput. Biol. Medicine.

[26]  Hasan Ocak,et al.  Optimal classification of epileptic seizures in EEG using wavelet analysis and genetic algorithm , 2008, Signal Process..

[27]  Elif Derya Ubeyli,et al.  Statistics over features: EEG signals analysis. , 2009, Computers in biology and medicine.

[28]  S. Sarbadhikari,et al.  Chaos in the brain: a short review alluding to epilepsy, depression, exercise and lateralization. , 2001, Medical engineering & physics.

[29]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.