The Knockout – The history of the knockout mouse and the surprising results for the synuclein proteins

[1]  Yan Wang,et al.  Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer , 2018, Cell.

[2]  Hong Wang,et al.  Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. , 2015, Human molecular genetics.

[3]  M. A. Afanasyeva,et al.  α-Synuclein knockout mice have cognitive impairments , 2012, Behavioural Brain Research.

[4]  M. Ruegg,et al.  Neuropathology in Mice Expressing Mouse Alpha-Synuclein , 2011, PloS one.

[5]  R. Kyle,et al.  Abbie Lathrop, the "mouse woman of Granby": rodent fancier and accidental genetics pioneer. , 2010, Mayo Clinic proceedings.

[6]  S. Chandra,et al.  αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction , 2010, Proceedings of the National Academy of Sciences.

[7]  V. Buchman,et al.  γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein , 2009, Human molecular genetics.

[8]  V. Baekelandt,et al.  Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. , 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[9]  M. Chesselet,et al.  In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson's disease? , 2008, Experimental Neurology.

[10]  K. Kitada,et al.  Transposon-tagged mutagenesis in the rat , 2007, Nature Methods.

[11]  R. Nussbaum,et al.  Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein , 2005, Molecular and Cellular Biology.

[12]  Giuseppe Battaglia,et al.  Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Richard Paylor,et al.  Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein , 2002, The Journal of Neuroscience.

[14]  J. Crow.  C. C. Little, cancer and inbred mice. , 2002, Genetics.

[15]  A. Björklund,et al.  Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System , 2002, The Journal of Neuroscience.

[16]  Makoto Hashimoto,et al.  β-Synuclein Inhibits α-Synuclein Aggregation A Possible Role as an Anti-Parkinsonian Factor , 2001, Neuron.

[17]  C. Specht,et al.  Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice , 2001, BMC Neuroscience.

[18]  Christian Haass,et al.  Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain , 2000, The Journal of Neuroscience.

[19]  P. Caroni,et al.  Neuropathology in Mice Expressing Human α-Synuclein , 2000, The Journal of Neuroscience.

[20]  Heidi Phillips,et al.  Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.

[21]  Mario R. Capecchi,et al.  Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes , 1988, Nature.

[22]  M. Capecchi,et al.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells , 1987, Cell.

[23]  R. Kucherlapati,et al.  Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination , 1985, Nature.

[24]  A. Bradley,et al.  Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines , 1984, Nature.

[25]  G. Wahl,et al.  Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules , 1982, Molecular and cellular biology.

[26]  G. Martin,et al.  Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Kaufman,et al.  Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.

[28]  M. Evans,et al.  Participation of cultured teratocarcinoma cells in mouse embryogenesis. , 1978, Journal of embryology and experimental morphology.

[29]  R. Jaenisch,et al.  Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[30]  D. Rutstein.  An open letter to Dr. Clarence Cook Little , 1958, CA: a cancer journal for clinicians.

[31]  David W. Melton,et al.  Targetted correction of a mutant HPRT gene in mouse embryonic stem cells , 1987, Nature.