Targeted Inhibition of Hsp90 in Combination with Metformin Modulates Programmed Cell Death Pathways in A549 Lung Cancer Cells.

[1]  Tammy M. Havener,et al.  Synergistic drug combinations and machine learning for drug repurposing in chordoma , 2020, Scientific Reports.

[2]  Adria Hasan,et al.  Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy. , 2020, Life sciences.

[3]  A. Bhattacharjee,et al.  Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis , 2020, Apoptosis.

[4]  H. Zali,et al.  HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy , 2020, Cancer investigation.

[5]  Tao Tao,et al.  mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges , 2020, Cell & Bioscience.

[6]  Sora Yoon,et al.  Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 , 2020, Experimental & Molecular Medicine.

[7]  Yan Fu,et al.  Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner , 2020, Cells.

[8]  F. Polticelli,et al.  Cytochrome c: An extreme multifunctional protein with a key role in cell fate. , 2019, International journal of biological macromolecules.

[9]  M. P. Dobay,et al.  Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7 , 2019, Science Advances.

[10]  K. Tsui,et al.  BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells , 2019, Oxidative medicine and cellular longevity.

[11]  Rensheng Wang,et al.  Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer , 2019, Experimental and therapeutic medicine.

[12]  Jai-Sing Yang,et al.  Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling , 2019, International journal of oncology.

[13]  D. Xiao,et al.  Novel application of metformin combined with targeted drugs on anticancer treatment , 2018, Cancer science.

[14]  Sang-Youel Park,et al.  Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS , 2018, International journal of molecular medicine.

[15]  Pierre M. Durand,et al.  The Nature of Programmed Cell Death , 2018, Biological Theory.

[16]  S. Dhamija,et al.  Beclin 1 Phosphorylation – at the Center of Autophagy Regulation , 2018, Front. Cell Dev. Biol..

[17]  C. Pathak,et al.  “Programmed Cell Death: A Process of Death for Survival” – How Far Terminology Pertinent for Cell Death in Unicellular Organisms , 2018, Journal of cell death.

[18]  Xingya Wang,et al.  Dual Effects of Metformin on Adipogenic Differentiation of 3T3-L1 Preadipocyte in AMPK-Dependent and Independent Manners , 2018, International journal of molecular sciences.

[19]  Shuanying Yang,et al.  Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review). , 2017, International journal of oncology.

[20]  Sheng-Cai Lin,et al.  AMPK: Sensing Glucose as well as Cellular Energy Status. , 2017, Cell metabolism.

[21]  Sang-We Kim,et al.  HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2. , 2017, Cancer letters.

[22]  X. Xiong,et al.  The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders , 2017, Oxidative medicine and cellular longevity.

[23]  Y. Jiao,et al.  Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway , 2017, International journal of biological sciences.

[24]  M. Gariboldi,et al.  Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production , 2017, Scientific Reports.

[25]  M. Lohani,et al.  Molecular docking analysis of aplysin analogs targeting survivin protein , 2017, Bioinformation.

[26]  Ke Chen,et al.  Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1‐dependent pathway , 2017, Molecular oncology.

[27]  K. Tennekoon,et al.  In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells , 2017, BioMed research international.

[28]  P. Wee,et al.  Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways , 2017, Cancers.

[29]  G. Fimia,et al.  Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate , 2017, Front. Oncol..

[30]  Herman Yeger,et al.  Combination therapy in combating cancer , 2017, Oncotarget.

[31]  Mei Peng,et al.  Combination of metformin with chemotherapeutic drugs via different molecular mechanisms. , 2017, Cancer treatment reviews.

[32]  Ping Li,et al.  Caspase-9: structure, mechanisms and clinical application , 2017, Oncotarget.

[33]  Z. Wang,et al.  Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression. , 2017, Cancer letters.

[34]  R. Subramani,et al.  Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway , 2016, Oncotarget.

[35]  Adria Hasan,et al.  ER chaperone GRP78 regulates autophagy by modulation of p53 localization. , 2017, Frontiers in bioscience.

[36]  V. Boudy,et al.  Metformin: An anti-diabetic drug to fight cancer. , 2016, Pharmacological research.

[37]  J. Petrik,et al.  Akt isoform specific effects in ovarian cancer progression , 2016, Oncotarget.

[38]  Wei Zheng,et al.  Drug combination therapy increases successful drug repositioning. , 2016, Drug discovery today.

[39]  A. Brunet,et al.  AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. , 2016, Trends in cell biology.

[40]  Na Ye,et al.  Direct Activation of Bax Protein for Cancer Therapy , 2016, Medicinal research reviews.

[41]  Xiaoming Jiang,et al.  Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer , 2016, Autophagy.

[42]  E. Gabrielson,et al.  AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer , 2015, Oncotarget.

[43]  Adrianna Skoneczna,et al.  Mitochondria-nucleus network for genome stability. , 2015, Free radical biology & medicine.

[44]  G. Alexiou,et al.  The role of heat shock proteins in cancer. , 2015, Cancer letters.

[45]  Nidhi Khurana,et al.  Hsp90, the Concertmaster: Tuning Transcription , 2015, Front. Oncol..

[46]  T. Mak,et al.  Caspase functions in cell death and disease. , 2015, Cold Spring Harbor perspectives in biology.

[47]  Osamu Nakamura,et al.  Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells , 2014, International journal of oncology.

[48]  A. Dillin,et al.  The role of protein clearance mechanisms in organismal ageing and age-related diseases , 2014, Nature Communications.

[49]  Haijian Wu,et al.  Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases , 2014, Molecular Neurobiology.

[50]  X. Song,et al.  Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer , 2014, Cell Death and Disease.

[51]  G. Dewson,et al.  Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function , 2014, Cell Death and Differentiation.

[52]  Jiri Polivka,et al.  Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. , 2014, Pharmacology & therapeutics.

[53]  P. Panda,et al.  Autophagy and apoptosis: where do they meet? , 2014, Apoptosis.

[54]  Eric H. Baehrecke,et al.  Self-consumption: the interplay of autophagy and apoptosis , 2014, Nature Reviews Molecular Cell Biology.

[55]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[56]  Anni I. Nieminen,et al.  Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis , 2013, Proceedings of the National Academy of Sciences.

[57]  G. Takaesu,et al.  Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy , 2012, Nature Structural &Molecular Biology.

[58]  Peng Huang,et al.  Targeting cancer cell mitochondria as a therapeutic approach. , 2013, Future medicinal chemistry.

[59]  C. Kieda,et al.  ROS implication in a new antitumor strategy based on non‐thermal plasma , 2012, International journal of cancer.

[60]  Jing Geng,et al.  Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation. , 2012, Cellular signalling.

[61]  H. Rikiishi Novel Insights into the Interplay between Apoptosis and Autophagy , 2012, International journal of cell biology.

[62]  A. Toker Achieving specificity in Akt signaling in cancer. , 2012, Advances in biological regulation.

[63]  K. Pantel,et al.  Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells. , 2011, Cellular signalling.

[64]  H. Koo,et al.  Roles of AKT1 and AKT2 in non‐small cell lung cancer cell survival, growth, and migration , 2011, Cancer science.

[65]  R. Xiang,et al.  Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll‐like receptor‐mediated autophagy , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[66]  D. Dickson,et al.  Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease , 2011, The Journal of cell biology.

[67]  A. Cuervo,et al.  Chaperone-mediated autophagy in protein quality control. , 2011, Current opinion in cell biology.

[68]  A. Nakagawara,et al.  Role of p53 in Cell Death and Human Cancers , 2011, Cancers.

[69]  T. Merriam,et al.  Apoptosis induces Bcl-XS and cleaved Bcl-XL in chronic lymphocytic leukaemia. , 2011, Biochemical and biophysical research communications.

[70]  M. Maiuri,et al.  Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1 , 2010, Oncogene.

[71]  C. Kenyon The genetics of ageing , 2010, Nature.

[72]  Mengwei Zang,et al.  AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. , 2010, Future oncology.

[73]  J. Bartlett,et al.  Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH , 2010, Histopathology.

[74]  D. Rubinsztein,et al.  Apoptosis blocks Beclin 1-dependent autophagosome synthesis – an effect rescued by Bcl-xL , 2009, Cell Death and Differentiation.

[75]  Sandeep Krishna,et al.  Stress-specific response of the p53-Mdm2 feedback loop , 2010, BMC Systems Biology.

[76]  Anna Lisa Maniero,et al.  Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. , 2009, Biochimica et biophysica acta.

[77]  D. Green,et al.  Cytoplasmic functions of the tumour suppressor p53 , 2009, Nature.

[78]  J. Kim,et al.  Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells. , 2009, Cancer letters.

[79]  N. Hay,et al.  Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. , 2008, Cancer cell.

[80]  Xin Cai,et al.  Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage , 2008, Proceedings of the National Academy of Sciences.

[81]  W. Zong,et al.  p53 in autophagy control , 2008, Cell cycle.

[82]  M. Karin,et al.  p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2008, Cell.

[83]  E. Barrón,et al.  The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells , 2008, Cell Death and Differentiation.

[84]  Nektarios Tavernarakis,et al.  Regulation of autophagy by cytoplasmic p53 , 2008, Nature Cell Biology.

[85]  W. Bursch,et al.  Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes , 2007, Cell Death and Differentiation.

[86]  U. Stochaj,et al.  Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway. , 2007, American journal of physiology. Cell physiology.

[87]  T. Pozzan,et al.  Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. , 2007, Trends in cell biology.

[88]  D. Green,et al.  GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation , 2007, Cell.

[89]  L. Moretti,et al.  Switch Between Apoptosis and Autophagy: Radiation-Induced Endoplasmic Reticulum Stress? , 2007, Cell cycle.

[90]  J. Dice Chaperone-Mediated Autophagy , 2007, Autophagy.

[91]  F. Cordelières,et al.  A guided tour into subcellular colocalization analysis in light microscopy , 2006, Journal of microscopy.

[92]  Thomas Schaffner,et al.  Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis , 2006, Nature Cell Biology.

[93]  Jinsong Liu,et al.  Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. , 2006, Cancer cell.

[94]  Ting-Chao Chou,et al.  Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies , 2006, Pharmacological Reviews.

[95]  T. Fan,et al.  Caspase family proteases and apoptosis. , 2005, Acta biochimica et biophysica Sinica.

[96]  S. Lindquist,et al.  HSP90 and the chaperoning of cancer , 2005, Nature Reviews Cancer.

[97]  Russell G. Jones,et al.  AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. , 2005, Molecular cell.

[98]  Stuart K. Calderwood,et al.  Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications , 2005, Cell stress & chaperones.

[99]  Daniel J. Klionsky,et al.  Autophagy in Health and Disease: A Double-Edged Sword , 2004, Science.

[100]  N. Ruderman,et al.  AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. , 2004, Biochemical and biophysical research communications.

[101]  T. Nishizaki,et al.  Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. , 2004, Biochemical pharmacology.

[102]  Peter Csermely,et al.  Response to Associate Editor , 2016 .

[103]  L. Rasmussen,et al.  Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae. , 2003, Nucleic acids research.

[104]  Gen Sheng Wu,et al.  Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line , 2002, Oncogene.

[105]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[106]  Honglin Zhou,et al.  Akt Regulates Cell Survival and Apoptosis at a Postmitochondrial Level , 2000, The Journal of cell biology.

[107]  U Alon,et al.  Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[108]  Steven J. Sollott,et al.  Reactive Oxygen Species (Ros-Induced) Ros Release , 2000, The Journal of experimental medicine.

[109]  T. Tsuruo,et al.  Modulation of Akt kinase activity by binding to Hsp90. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[110]  M. Owen,et al.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.

[111]  Stephen N. Jones,et al.  Regulation of p53 stability by Mdm2 , 1997, Nature.

[112]  D. Peters,et al.  Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. , 1995, Drugs.

[113]  L. Ji,et al.  Effects of Adriamycin on heart mitochondrial function in rested and exercised rats. , 1994, Biochemical pharmacology.