The effects of topical liposomal resveratrol on incisional and excisional wound healing process

Address for Correspondence/Yazışma Adresi: Mehmet Yalçın Günal MD, Alanya Alaaddin Keykubat University Faculty of Medicine, Department of Physiology, Antalya, Turkey Phone: +90 532 557 73 56 E-mail: yalcin.gunal@alanya.edu.tr Received/Geliş Tarihi: 05.08.2018 Accepted/Kabul Tarihi: 02.03.2019 ORCID: orcid.org/0000-0001-7702-2441 Background and Design: The objective of this study was to investigate the wound healing activity of different concentrations of liposomal trans-resveratrol formulations on incisional and excisional wounds in rats. Materials and Methods: The wound healing effect was tested by an excisional and incisional wound model. Wound closure was measured for 12 days. On the 12 day of the study, maximal load, maximum stress, stress, and % of elongation values were evaluated in the incisional wound. In addition, angiogenesis, granulation tissue thickness, epidermal and dermal regeneration values, and macroscopic photographic analyses were evaluated in the excisional wound. Results: When the wound tissue surface healing rates were evaluated, similar effects were observed at the end of the 10 and 12 days between the 5% Res group and the commercial product containing 1% Centella asiatica extract used as the reference molecule. Histological evaluation showed that 1% Res and 5% Res groups induced significant wound healing activity compared to the control group. Furthermore, 1% Res and 5% Res groups increased wound healing rates by promoting granulation tissue, epidermal, and dermal regeneration as well as angiogenesis. Conclusion: Liposomal formulations containing 1% and 5% resveratrol were found to have positive effects on the healing process, both on excisional and incisional wound tissues.

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