Combined reperfusion strategies in ST-segment elevation MI: Rationale and current role

Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy for ST-elevation myocardial infarction (MI), but most patients do not arrive at a PCI facility within the recommended 90 minutes of first medical contact. If delay is expected, timely thrombolysis is recommended, followed by early transfer for PCI. The authors review the rationale behind three combined reperfusion strategies—facilitated PCI, pharmacoinvasive therapy, and rescue PCI—and data on their effectiveness. In geographic areas where percutaneous coronary intervention (PCI) is not immediately available, the best strategy may be to give thrombolysis immediately and then to transfer the patient to a PCI hospital.

[1]  S. Halvorsen,et al.  Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction). , 2010, Journal of the American College of Cardiology.

[2]  S. Werns.  Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction , 2010 .

[3]  S. Pedersen,et al.  Field triage reduces treatment delay and improves long-term clinical outcome in patients with acute ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. , 2009, Journal of the American College of Cardiology.

[4]  R. Smalling.  Ischemic time: the new gold standard for ST-segment elevation myocardial infarction care. , 2009, Journal of the American College of Cardiology.

[5]  P. Armstrong,et al.  The impact of place of enrollment and delay to reperfusion on 90-day post-infarction mortality in the ASSENT-4 PCI trial: assessment of the safety and efficacy of a new treatment strategy with percutaneous coronary intervention. , 2009, JACC. Cardiovascular interventions.

[6]  E. Topol,et al.  Benefit of facilitated percutaneous coronary intervention in high-risk ST-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals. , 2009, JACC. Cardiovascular interventions.

[7]  S. Rafelt,et al.  Longer-term follow-up of patients recruited to the REACT (Rescue Angioplasty Versus Conservative Treatment or Repeat Thrombolysis) trial. , 2009, Journal of the American College of Cardiology.

[8]  Michael Weis,et al.  Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. , 2008, European heart journal.

[9]  L. Wallentin,et al.  Early Invasive Therapy in Non-ST-elevation Myocardial Infarction Improves Survival Although Benefit Declines with Worsening Renal Function - Data from the Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) , 2008 .

[10]  G. Schuler,et al.  Reduced-dose fibrinolytic acceleration of ST-segment elevation myocardial infarction treatment coupled with urgent percutaneous coronary intervention compared to primary percutaneous coronary intervention alone results of the AMICO (Alliance for Myocardial Infarction Care Optimization) Registry. , 2008, JACC. Cardiovascular interventions.

[11]  H. Krumholz,et al.  An early invasive strategy versus ischemia-guided management after fibrinolytic therapy for ST-segment elevation myocardial infarction: a meta-analysis of contemporary randomized controlled trials. , 2008, American heart journal.

[12]  J. Ferrières,et al.  Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Acute Myocardial Infarction Data From the French Registry on Acute ST-Elevation Myocardial Infarction (FAST-MI) , 2008 .

[13]  H. Krumholz,et al.  Time-to-reperfusion in patients undergoing interhospital transfer for primary percutaneous coronary intervention in the U.S: an analysis of 2005 and 2006 data from the National Cardiovascular Data Registry. , 2008, Journal of the American College of Cardiology.

[14]  E. Topol,et al.  Facilitated PCI in patients with ST-elevation myocardial infarction. , 2008, The New England journal of medicine.

[15]  M. Flather,et al.  Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial , 2008, The Lancet.

[16]  S. Werns.  Rescue Angioplasty or Repeat Fibrinolysis After Failed Fibrinolytic Therapy for ST-Segment Myocardial Infarction: A Meta-Analysis of Randomized Trials , 2008 .

[17]  Timothy D. Henry,et al.  A Regional System to Provide Timely Access to Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction , 2007, Circulation.

[18]  D. Moliterno,et al.  The Timely Coupling of Mechanical Revascularization following Thrombolysis for Myocardial Infarction , 2007, Cardiology.

[19]  David P Miller,et al.  Hospital Delays in Reperfusion for ST-Elevation Myocardial Infarction: Implications When Selecting a Reperfusion Strategy , 2006, Circulation.

[20]  G. Maurer,et al.  Implementation of Guidelines Improves the Standard of Care: The Viennese Registry on Reperfusion Strategies in ST-Elevation Myocardial Infarction (Vienna STEMI Registry) , 2006, Circulation.

[21]  L. Wallentin,et al.  Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction. , 2006, European heart journal.

[22]  P. Armstrong,et al.  Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial , 2006, The Lancet.

[23]  Gd Rotterdam.  Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients , 2006 .

[24]  G. Wells,et al.  Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). , 2005, Journal of the American College of Cardiology.

[25]  F. Fernández‐Avilés,et al.  Routine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial , 2004, The Lancet.

[26]  Lippincott Williams Wilkins,et al.  ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction , 2004 .

[27]  R. Califf,et al.  Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. , 2004, Journal of the American College of Cardiology.

[28]  P. Touboul,et al.  Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty: Data From the CAPTIM Randomized Clinical Trial , 2003, Circulation.

[29]  B. Nallamothu,et al.  Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything? , 2003, The American journal of cardiology.

[30]  Klaus Rasmussen,et al.  A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. , 2003, The New England journal of medicine.

[31]  C. Hofer,et al.  Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. , 2003, Journal of the American College of Cardiology.

[32]  L. Wallentin,et al.  Fibrinolytic therapy in patients 75 years and older with ST-segment-elevation myocardial infarction. One-year follow-up of a large prospective cohort☆ , 2003 .

[33]  H. White,et al.  Cardiogenic shock caused by right ventricular infarction: a report from the SHOCK registry. , 2003, Journal of the American College of Cardiology.

[34]  J. Boura,et al.  Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction : a quantitative review of 23 randomised trials , 2022 .

[35]  M. Aschermann,et al.  Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial--PRAGUE-2. , 2003, European heart journal.

[36]  H. White,et al.  One-year survival following early revascularization for cardiogenic shock. , 2001, JAMA.

[37]  E. Antman,et al.  High levels of platelet inhibition with abciximab despite heightened platelet activation and aggregation during thrombolysis for acute myocardial infarction: results from TIMI (thrombolysis in myocardial infarction) 14. , 2000, Circulation.

[38]  E. Topol,et al.  Effects of reteplase and alteplase on platelet aggregation and major receptor expression during the first 24 hours of acute myocardial infarction treatment. GUSTO-III Investigators. Global Use of Strategies to Open Occluded Coronary Arteries. , 1998, Journal of the American College of Cardiology.

[39]  Eric Boersma,et al.  Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour , 1996, The Lancet.

[40]  Fibrinolytictherapytrialistsf.  Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients , 1994 .

[41]  Gusto Angiographic Investigators.  The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. , 1993, The New England journal of medicine.

[42]  J O'Keefe,et al.  A Comparison of Immediate Angioplasty with Thrombolytic Therapy for Acute Myocardial Infarction , 1993 .

[43]  Prehospital thrombolytic therapy in patients with suspected acute myocardial infarction. , 1993, The New England journal of medicine.

[44]  G. Rasmanis,et al.  Evidence of increased platelet activation after thrombolysis in patients with acute myocardial infarction , 1992, British heart journal.