A Near‐Infrared Laser‐Activated “Nanobomb” for Breaking the Barriers to MicroRNA Delivery

A near-infrared laser-activated "nanobomb" is synthesized using lipid and multiple polymers to break the extra-cellular and intracellular barriers to cytosolic delivery of microRNAs. The nanobomb can be used to effectively destroy tumors and cancer stem-like cells in vitro and in vivo with minimal side effects.

[1]  Xiongbin Lu,et al.  Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells. , 2015, ACS nano.

[2]  L. Stassen,et al.  Near-Infrared Fluorescence Imaging for Real-Time Intraoperative Anatomical Guidance in Minimally Invasive Surgery: A Systematic Review of the Literature , 2015, World Journal of Surgery.

[3]  T. Ji,et al.  Multiple Layer‐by‐Layer Lipid‐Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models , 2015 .

[4]  Xiongbin Lu,et al.  Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules. , 2014, Biomaterials.

[5]  Zhen Gu,et al.  ATP-triggered anticancer drug delivery , 2014, Nature Communications.

[6]  Duxin Sun,et al.  The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel. , 2013, Biomaterials.

[7]  E. Puré,et al.  Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models. , 2013, Nanoscale.

[8]  R. Zhao,et al.  Engineering the Assemblies of Biomaterial Nanocarriers for Delivery of Multiple Theranostic Agents with Enhanced Antitumor Efficacy , 2013, Advances in Materials.

[9]  Yifan Ma,et al.  Single-step assembly of DOX/ICG loaded lipid--polymer nanoparticles for highly effective chemo-photothermal combination therapy. , 2013, ACS nano.

[10]  Younan Xia,et al.  A thermoresponsive bubble-generating liposomal system for triggering localized extracellular drug delivery. , 2013, ACS nano.

[11]  K. Kelnar,et al.  Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44 , 2010, Nature Medicine.

[12]  Xiaoming He,et al.  Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. , 2010, ACS nano.

[13]  Subra Suresh,et al.  Size‐Dependent Endocytosis of Nanoparticles , 2009, Advanced materials.

[14]  Kevin Braeckmans,et al.  Extracellular barriers in respiratory gene therapy☆ , 2008, Advanced Drug Delivery Reviews.

[15]  Robert Langer,et al.  Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. , 2008, ACS nano.

[16]  N. Maitland,et al.  Prospective identification of tumorigenic prostate cancer stem cells. , 2005, Cancer research.

[17]  B. Petersen,et al.  AUTOIMMUNE PANCREATITIS: DIAGNOSIS USING HISTOLOGY, IMAGING, SEROLOGY, OTHER ORGAN INVOLVEMENT AND RESPONSE TO STEROIDS , 2005 .

[18]  C. Croce,et al.  miRNAs, Cancer, and Stem Cell Division , 2005, Cell.

[19]  Michael Dean,et al.  Tumour stem cells and drug resistance , 2005, Nature Reviews Cancer.

[20]  T. Kondo,et al.  Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Small,et al.  Hyaluronic Acid (Ha) Binding to Cd44 Activates Rac1 and Induces Lamellipodia Outgrowth , 2000, The Journal of cell biology.

[22]  Joseph Zabner,et al.  Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*) , 1995, The Journal of Biological Chemistry.