Dynamic image interpretation of MRI of the breast

Dynamic breast MRI provides information on both lesion cross‐sectional morphology and functional lesion features such as vascularity/perfusion and vessel permeability. This review gives an overview of the historical background of dynamic contrast‐enhanced breast MRI. It explains the technique's pathophysiological basis, describes the various technical approaches that have been pursued and the corresponding interpretation guidelines that have been proposed (including their respective diagnostic accuracies), and presents established and evolving clinical applications of the “dynamic approach” to breast MRI. J. Magn. Reson. Imaging 2000;12:965–974. © 2000 Wiley‐Liss, Inc.

[1]  R. Brasch,et al.  Contrast-Enhanced Magnetic Resonance Imaging Estimation of Altered Capillary Permeability in Experimental Mammary Carcinomas After X-Irradiation , 1994, Investigative radiology.

[2]  T. Helbich,et al.  A new polysaccharide macromolecular contrast agent for MR imaging: Biodistribution and imaging characteristics , 2000, Journal of magnetic resonance imaging : JMRI.

[3]  G Brix,et al.  Pathophysiologic basis of contrast enhancement in breast tumors , 1999, Journal of magnetic resonance imaging : JMRI.

[4]  J. Hogg Magnetic resonance imaging. , 1994, Journal of the Royal Naval Medical Service.

[5]  J. Folkman,et al.  Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. , 1991, The New England journal of medicine.

[6]  P Aspelin,et al.  Contrast-enhanced MR imaging as a prognostic indicator of breast cancer , 1998, Acta radiologica.

[7]  C. Kuhl,et al.  MRI of breast tumors , 2000, European Radiology.

[8]  M. Reiser,et al.  MR-Mammographie bei 0,5 Tesla. I: Vergleich von Bildqualität und Sensitivität der MR-Mammographie bei 0,5 und 1,5 T , 1995 .

[9]  R. Brasch,et al.  Contrast-enhanced MR imaging assessment of tumor capillary permeability: effect of irradiation on delivery of chemotherapy. , 1996, Radiology.

[10]  Diagnostic potential of ultrafast contrast-enhanced MRI of the breast in hypervascularized lesions: are there advantages in comparison with standard dynamic MRI? , 1999, Journal of computer assisted tomography.

[11]  J F Debatin,et al.  Improved diagnostic accuracy in dynamic contrast enhanced MRI of the breast by combined quantitative and qualitative analysis. , 1998, The British journal of radiology.

[12]  G Brix,et al.  MR mammography with pharmacokinetic mapping for monitoring of breast cancer treatment during neoadjuvant therapy. , 1994, Magnetic resonance imaging clinics of North America.

[13]  A Heinig,et al.  Contrast-enhanced MRI of the breast: accuracy, value, controversies, solutions. , 1997, European journal of radiology.

[14]  G Lutterbey,et al.  Healthy premenopausal breast parenchyma in dynamic contrast-enhanced MR imaging of the breast: normal contrast medium enhancement and cyclical-phase dependency. , 1997, Radiology.

[15]  M D Schnall,et al.  Staging of suspected breast cancer: effect of MR imaging and MR-guided biopsy. , 1995, Radiology.

[16]  R. Weissleder,et al.  In vivo assessment of vascular endothelial growth factor‐induced angiogenesis , 1999, International journal of cancer.

[17]  M. Wendland,et al.  Macromolecular contrast media. A new approach for characterising breast tumors with MR-mammography , 1997, Der Radiologe.

[18]  S. Edge,et al.  Suspect breast lesions: findings at dynamic gadolinium-enhanced MR imaging correlated with mammographic and pathologic features. , 1995, Radiology.

[19]  E Grabbe,et al.  Breast carcinoma: effect of preoperative contrast-enhanced MR imaging on the therapeutic approach. , 1999, Radiology.

[20]  R. Paola,et al.  Correlation Between Contrast Enhancement in Dynamic Magnetic Resonance Imaging of the Breast and Tumor Angiogenesis , 1994, Investigative radiology.

[21]  Rolf Vosshenrich,et al.  Signalverhalten maligner und benigner Läsionen in der dynamischen 2D-MRT der Mamma , 1993 .

[22]  C. Kuhl,et al.  Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? , 1999, Radiology.

[23]  P. Stomper,et al.  Invasive breast carcinoma: Analysis of dynamic magnetic resonance imaging enhancement features and cell proliferative activity determined by DNA S‐phase percentage , 1996 .

[24]  C. Claussen,et al.  Menstrual cycle and age: influence on parenchymal contrast medium enhancement in MR imaging of the breast. , 1997, Radiology.

[25]  P. Aspelin,et al.  Mechanism of contrast enhancement in breast lesions at MR imaging , 1998, Acta radiologica.

[26]  R. Poulsom,et al.  Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis , 1998, The Journal of pathology.

[27]  S. Heywang-Köbrunner,et al.  Contrast‐Enhanced MRI of the Breast after Limited Surgery and Radiation Therapy , 1993, Journal of computer assisted tomography.

[28]  M. Rezai,et al.  [MR-mammography assessment of tumor response after neoadjuvant radiochemotherapy of locally advanced breast carcinoma]. , 1996, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[29]  M D Schnall,et al.  Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast. , 1997, AJR. American journal of roentgenology.

[30]  A. Schauer,et al.  Prognostic value of contrast-enhanced MR mammography in patients with breast cancer , 1997, European Radiology.

[31]  H. Arvaniti,et al.  Tumor angiogenesis in node-negative breast cancer: relationship with relapse free survival. , 1996, Anticancer research.

[32]  D. Carney,et al.  Prognostic significance of microvessel density in lymph node negative breast carcinoma. , 1995, Human pathology.

[33]  D M Ikeda,et al.  Lesion Diagnosis Working Group Report , 1999, Journal of magnetic resonance imaging : JMRI.

[34]  C. Kuhl,et al.  Do T2‐weighted pulse sequences help with the differential diagnosis of enhancing lesions in dynamic breast MRI? , 1999, Journal of magnetic resonance imaging : JMRI.

[35]  N. van Bruggen,et al.  Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. , 1998, Cancer investigation.

[36]  C K Kuhl,et al.  Breast neoplasms: T2* susceptibility-contrast, first-pass perfusion MR imaging. , 1997, Radiology.

[37]  L J van Erning,et al.  MR characterization of suspicious breast lesions with a gadolinium-enhanced TurboFLASH subtraction technique. , 1994, Radiology.

[38]  W Vach,et al.  Vascular grading of angiogenesis: prognostic significance in breast cancer , 2000, British Journal of Cancer.

[39]  W. Kaiser,et al.  MR imaging of the breast: fast imaging sequences with and without Gd-DTPA. Preliminary observations. , 1989, Radiology.

[40]  S E Harms,et al.  Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imaging , 1996, Cancer.

[41]  J. Gieseke,et al.  MR-Mammographie bei 0,5 Tesla , 1995 .

[42]  D Krebs,et al.  Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results. , 2000, Radiology.

[43]  C. Boetes,et al.  False-negative MR imaging of malignant breast tumors , 1997, European Radiology.

[44]  H Zeitler,et al.  MRI of breast cancer: influence of chemotherapy on sensitivity. , 1997, The British journal of radiology.

[45]  S. Delorme,et al.  Locally advanced breast carcinoma: evaluation of mammography in the prediction of residual disease after induction chemotherapy. , 2000, Anticancer research.

[46]  S E Harms,et al.  MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation. , 1993, Radiology.

[47]  P J Drew,et al.  Microvessel density in invasive breast cancer assessed by dynamic gd‐dtpa enhanced MRI , 1997 .

[48]  D B Kopans,et al.  Dynamic echo-planar imaging of the breast: experience in diagnosing breast carcinoma and correlation with tumor angiogenesis. , 1997, Radiology.

[49]  C. Kuhl,et al.  [MR mammography at 0.5 tesla. I. Comparison of image quality and sensitivity of MR mammography at 0.5 and 1.5 T]. , 1995, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[50]  R. Gilles,et al.  Assessment of breast cancer recurrence with contrast-enhanced subtraction MR imaging: preliminary results in 26 patients. , 1993, Radiology.

[51]  E A Sickles,et al.  Dynamic high-spatial-resolution MR imaging of suspicious breast lesions: diagnostic criteria and interobserver variability. , 2000, AJR. American journal of roentgenology.

[52]  O Lucidarme,et al.  Nonpalpable breast tumors: diagnosis with contrast-enhanced subtraction dynamic MR imaging. , 1994, Radiology.

[53]  U. Fischer,et al.  MR imaging of mammographically detected clustered microcalcifications: is there any value? , 1998, Radiology.

[54]  J. Folkman,et al.  Angiogenic factors. , 1987, Science.

[55]  L D Buadu,et al.  Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis. , 1996, Radiology.

[56]  R Musumeci,et al.  Locally Advanced Breast Cancer Treated with Primary Chemotherapy: Comparison between Magnetic Resonance Imaging and Pathologic Evaluation of Residual Disease , 1999, Tumori.

[57]  W E Reddick,et al.  MR imaging of tumor microcirculation: Promise for the new millenium , 1999, Journal of magnetic resonance imaging : JMRI.

[58]  D. Hanahan,et al.  Induction of angiogenesis during the transition from hyperplasia to neoplasia , 1989, Nature.

[59]  A Horsman,et al.  Dynamic MR imaging of invasive breast cancer: correlation with tumour grade and other histological factors. , 1997, The British journal of radiology.

[60]  H. Augustin,et al.  Prognostic value of angiogenesis in mammary tumors. , 1998, Anticancer research.

[61]  W A Kaiser [Magnetic resonance tomography of the breast. The results of 253 examinations]. , 1989, Deutsche medizinische Wochenschrift.

[62]  M. Hall-Craggs,et al.  Breast surgery after neoadjuvant treatment. Is it necessary? , 1996, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[63]  A Horsman,et al.  Observer variability in the interpretation of contrast enhanced MRI of the breast. , 1996, The British journal of radiology.

[64]  S. Heywang,et al.  MR imaging of the breast with Gd-DTPA: use and limitations. , 1989, Radiology.

[65]  R. Gilles,et al.  Locally advanced breast cancer: contrast-enhanced subtraction MR imaging of response to preoperative chemotherapy. , 1994, Radiology.

[66]  Scott Fields,et al.  Mapping pathophysiological features of breast tumors by MRI at high spatial resolution , 1997, Nature Medicine.

[67]  S. Heywang,et al.  MR imaging of the breast using gadolinium-DTPA. , 1986, Journal of computer assisted tomography.

[68]  M. J. Aceñero,et al.  Vascular density as a prognostic indicator for invasive ductal breast carcinoma , 1998, Virchows Archiv.