Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

[1]  B. Yoder,et al.  An essential role for dermal primary cilia in hair follicle morphogenesis. , 2009, The Journal of investigative dermatology.

[2]  V. Grachtchouk,et al.  Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling , 2008, Nature Genetics.

[3]  H. Ko,et al.  FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. , 2008, Developmental biology.

[4]  Hua Tian,et al.  A paracrine requirement for hedgehog signalling in cancer , 2008, Nature.

[5]  Elaine Fuchs,et al.  Skin stem cells: rising to the surface , 2008, The Journal of cell biology.

[6]  S. Fisher,et al.  Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response , 2007, Nature Genetics.

[7]  K. Anderson,et al.  Cilia and developmental signaling. , 2007, Annual review of cell and developmental biology.

[8]  M. Scott,et al.  Patched 1 Regulates Hedgehog Signaling at the Primary Cilium , 2022 .

[9]  Allen Li,et al.  Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. , 2007, Cancer research.

[10]  W. Jackson,et al.  Intraflagellar transport is essential for endochondral bone formation , 2007, Development.

[11]  Lee L. Rubin,et al.  Targeting the Hedgehog pathway in cancer , 2006, Nature Reviews Drug Discovery.

[12]  M. Hebrok,et al.  Hedgehog/Ras interactions regulate early stages of pancreatic cancer. , 2006, Genes & development.

[13]  Keith L Ligon,et al.  A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. , 2006, Cancer research.

[14]  C. Emerson,et al.  Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Pao-Tien Chuang,et al.  GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis , 2006, Development.

[16]  Johan Ericson,et al.  Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. , 2005, Developmental biology.

[17]  Peter Satir,et al.  PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts , 2005, Current Biology.

[18]  Didier Y. R. Stainier,et al.  Vertebrate Smoothened functions at the primary cilium , 2005, Nature.

[19]  Qihong Zhang,et al.  Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function , 2005, PLoS genetics.

[20]  K. Anderson,et al.  Cilia and Hedgehog responsiveness in the mouse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Aimin Liu,et al.  Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors , 2005, Development.

[22]  M. Scott,et al.  Communicating with Hedgehogs , 2005, Nature Reviews Molecular Cell Biology.

[23]  K. Kaibuchi,et al.  Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity , 2004, Nature Cell Biology.

[24]  Lee Niswander,et al.  Hedgehog signalling in the mouse requires intraflagellar transport proteins , 2003, Nature.

[25]  H. Kiyosawa,et al.  Expression of the GLI2 oncogene and its isoforms in human basal cell carcinoma , 2003, The British journal of dermatology.

[26]  C. Hui,et al.  Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. , 2003, Genes & development.

[27]  Daniel Chui,et al.  Genetic Evidence for Selective Transport of Opsin and Arrestin by Kinesin-II in Mammalian Photoreceptors , 2000, Cell.

[28]  E. Fuchs,et al.  The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  R. Paus,et al.  Sonic hedgehog signaling is essential for hair development , 1998, Current Biology.

[30]  M. Wolter,et al.  Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. , 1998, Cancer research.

[31]  Q. Gu,et al.  Activating Smoothened mutations in sporadic basal-cell carcinoma , 1998, Nature.

[32]  N. Dahmane,et al.  Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours , 1997, Nature.

[33]  M. Wolter,et al.  Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. , 1997, Cancer research.

[34]  M. Scott,et al.  Basal cell carcinomas in mice overexpressing sonic hedgehog. , 1997, Science.

[35]  A. Joyner,et al.  A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene , 1993, Nature Genetics.

[36]  Wilson Rb,et al.  Isolated flagella in human skin. Election microscopic observations. , 1963 .

[37]  Gerald C. Chu,et al.  GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. , 2009, Genes & development.

[38]  Amy E. Shyer,et al.  Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms , 2008, Nature Cell Biology.

[39]  W Gaffield,et al.  Essential role for Sonic hedgehog during hair follicle morphogenesis. , 1999, Developmental biology.

[40]  Philippe Soriano Generalized lacZ expression with the ROSA26 Cre reporter strain , 1999, Nature Genetics.

[41]  R. Wilson,et al.  Isolated flagella in human skin. Election microscopic observations. , 1963, Laboratory investigation; a journal of technical methods and pathology.