Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis
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[1] Yuhong Yang,et al. TGF-β Enhances Effector Th1 Cell Activation but Promotes Self-Regulation via IL-10 , 2010, The Journal of Immunology.
[2] Eva Tolosa,et al. Phenotypical Characterization of Human Th17 Cells Unambiguously Identified by Surface IL-17A Expression1 , 2009, The Journal of Immunology.
[3] T. Pekmezović,et al. Expression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment? , 2009, Journal of Neuroimmunology.
[4] Lionel B Ivashkiv,et al. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. , 2009, Immunity.
[5] P. Duquette,et al. Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis , 2009, Annals of neurology.
[6] K. Mills,et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. , 2009, Immunity.
[7] Yuhong Yang,et al. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells , 2009, The Journal of experimental medicine.
[8] D. Unutmaz. RORC2: The master of human Th17 cell programming , 2009, European journal of immunology.
[9] M. Levings,et al. The role of retinoic acid‐related orphan receptor variant 2 and IL‐17 in the development and function of human CD4+ T cells , 2009, European journal of immunology.
[10] D. Littman,et al. Plasticity of CD4+ T cell lineage differentiation. , 2009, Immunity.
[11] Gary D. Stormo,et al. The AP-1 transcription factor Batf controls TH17 differentiation , 2009, Nature.
[12] V. Kuchroo,et al. Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells1 , 2009, The Journal of Immunology.
[13] Danila Valmori,et al. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt , 2009, Proceedings of the National Academy of Sciences.
[14] A. Adamson,et al. The Current STATus of lymphocyte signaling: new roles for old players. , 2009, Current opinion in immunology.
[15] D. Littman,et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans , 2009, Proceedings of the National Academy of Sciences.
[16] M. Racke,et al. Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis? , 2009, Expert review of neurotherapeutics.
[17] C. Elson,et al. Late developmental plasticity in the T helper 17 lineage. , 2009, Immunity.
[18] B. Becher,et al. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. , 2008, The Journal of clinical investigation.
[19] D. Vignali,et al. Interleukin‐35: odd one out or part of the family? , 2008, Immunological reviews.
[20] L. Cosmi,et al. The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. , 2008, International immunology.
[21] Warren Strober,et al. Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells , 2008, Nature Immunology.
[22] Hyun-Dong Chang,et al. Th memory for interleukin‐17 expression is stable in vivo , 2008, European journal of immunology.
[23] P. Rutgeerts,et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. , 2008, Gastroenterology.
[24] Irma Joosten,et al. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. , 2008, Blood.
[25] C. Constantinescu,et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study , 2008, The Lancet Neurology.
[26] L. Cosmi,et al. Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor , 2008, The Journal of experimental medicine.
[27] B. Segal,et al. IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition , 2008, The Journal of experimental medicine.
[28] David E. Anderson,et al. IL-21 and TGF-β are required for differentiation of human TH17 cells , 2008, Nature.
[29] Jianfei Yang,et al. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells , 2008, European journal of immunology.
[30] R. Meier,et al. IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity in vivo , 2008, European journal of immunology.
[31] A. Yoshimura,et al. Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*♦ , 2008, Journal of Biological Chemistry.
[32] A. Kimball,et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) , 2008, The Lancet.
[33] D. Littman,et al. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt , 2008, Nature Immunology.
[34] H. Weiner,et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor , 2008, Nature.
[35] J. Buer,et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins , 2008, Nature.
[36] Yuelei Shen,et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.
[37] J. Goverman,et al. Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells , 2008, Nature Medicine.
[38] E. Wawrousek,et al. Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells1 , 2008, The Journal of Immunology.
[39] Guang-Xian Zhang,et al. Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. , 2008, Experimental and molecular pathology.
[40] Chen Dong,et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. , 2008, Immunity.
[41] J. Farber,et al. Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR61 , 2008, The Journal of Immunology.
[42] Lai Wei,et al. IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner* , 2007, Journal of Biological Chemistry.
[43] K. Boyd,et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function , 2007, Nature.
[44] Graham M Lord,et al. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes , 2007, Proceedings of the National Academy of Sciences.
[45] Nathalie Arbour,et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation , 2007, Nature Medicine.
[46] Roland Martin,et al. Multiple sclerosis: a complicated picture of autoimmunity , 2007, Nature Immunology.
[47] T. Mak,et al. The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 , 2007, Nature Immunology.
[48] D. Levy,et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways , 2007, Nature Immunology.
[49] Kathleen M. Smith,et al. Development, cytokine profile and function of human interleukin 17–producing helper T cells , 2007, Nature Immunology.
[50] L. Cosmi,et al. Phenotypic and functional features of human Th17 cells , 2007, The Journal of experimental medicine.
[51] F. Sallusto,et al. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells , 2007, Nature Immunology.
[52] Terry B. Strom,et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells , 2007, Nature.
[53] A. D. Panopoulos,et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells , 2007, Nature.
[54] D. Jarrossay,et al. Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells , 2007, Nature Immunology.
[55] D. G. Zisoulis,et al. Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1 , 2007, The Journal of Immunology.
[56] Chen Dong,et al. STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells* , 2007, Journal of Biological Chemistry.
[57] L. Hennighausen,et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.
[58] J. Leonard,et al. IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis , 2007, The Journal of Immunology.
[59] Guang-Xian Zhang,et al. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. , 2007, Brain : a journal of neurology.
[60] A. Lovett-racke,et al. T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity1 , 2007, The Journal of Immunology.
[61] D. Littman,et al. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.
[62] K. Honda,et al. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors , 2006, Nature Reviews Immunology.
[63] K. Honda,et al. Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors , 2006 .
[64] K. Mills,et al. A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis , 2006, The Journal of experimental medicine.
[65] Shailendra Giri,et al. T‐bet is essential for the progression of experimental autoimmune encephalomyelitis , 2006, Immunology.
[66] H. Weiner,et al. IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production , 2006, The Journal of Immunology.
[67] L. Hennighausen,et al. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[68] H. Weiner,et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.
[69] L. Presta,et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. , 2006, The Journal of clinical investigation.
[70] R. J. Hocking,et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.
[71] R. D. Hatton,et al. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages , 2005, Nature Immunology.
[72] R. Hintzen,et al. Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody1 , 2005, The Journal of Immunology.
[73] T. Mak,et al. Roles of interferon-regulatory factors in T-helper-cell differentiation , 2005, Nature Reviews Immunology.
[74] T. Mcclanahan,et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation , 2005, The Journal of experimental medicine.
[75] A. Lovett-racke,et al. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. , 2004, Immunity.
[76] S. Szabo,et al. Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis , 2004, The Journal of experimental medicine.
[77] B. '. ’t Hart,et al. Evaluating the validity of animal models for research into therapies for immune-based disorders. , 2004, Drug discovery today.
[78] Peter R. Galle,et al. Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7 , 2004, The Journal of Immunology.
[79] Li Li,et al. Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.
[80] M. Kamoun,et al. Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia , 2003, Journal of the Neurological Sciences.
[81] M. Kamoun,et al. Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis 1 , 2003, The Journal of Immunology.
[82] B. Becher,et al. IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. , 2003, The Journal of clinical investigation.
[83] M. Kamoun,et al. Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System1 , 2003, The Journal of Immunology.
[84] R. Kastelein,et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain , 2003, Nature.
[85] A. Gurney,et al. Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17* , 2003, The Journal of Biological Chemistry.
[86] J. Fanzo,et al. Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4* , 2002, The Journal of Biological Chemistry.
[87] M. Kamoun,et al. IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination1 , 2002, The Journal of Immunology.
[88] B. '. ’t Hart,et al. Prevention of Experimental Autoimmune Encephalomyelitis in Common Marmosets Using an Anti-IL-12p40 Monoclonal Antibody1 , 2002, Journal of Immunology.
[89] T. Mak,et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[90] B. Becher,et al. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. , 2002, The Journal of clinical investigation.
[91] L. Chodosh,et al. Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction , 2002, Nature Immunology.
[92] T. Mcclanahan,et al. A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1 , 2002, The Journal of Immunology.
[93] Jorge R. Oksenberg,et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis , 2002, Nature Medicine.
[94] L. Glimcher,et al. Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression , 2002, The Journal of experimental medicine.
[95] S. Szabo,et al. Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells , 2002, Science.
[96] A. Sher,et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[97] R. Bontrop,et al. Non‐human primate models of multiple sclerosis , 2001, Immunological reviews.
[98] S. Khoury,et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. , 2001, The Journal of clinical investigation.
[99] H. Kiyono,et al. Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). , 2001, Journal of autoimmunity.
[100] M. Leach,et al. Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death , 2001, The Journal of Immunology.
[101] Andrew L. Kung,et al. Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection , 2001, Science.
[102] J Wagner,et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. , 2000, Immunity.
[103] J. Frank,et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand , 2000, Nature Medicine.
[104] Richard A. Rudick,et al. Quantification of Self-Recognition in Multiple Sclerosis by Single-Cell Analysis of Cytokine Production1 , 2000, The Journal of Immunology.
[105] L. Glimcher,et al. Lineage commitment in the immune system: the T helper lymphocyte grows up. , 2000, Genes & development.
[106] S. Wittmer,et al. Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis , 2000, The Journal of experimental medicine.
[107] A. Pierani,et al. Requirement for RORgamma in thymocyte survival and lymphoid organ development. , 2000, Science.
[108] Laurie H Glimcher,et al. A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.
[109] A. Komiyama,et al. Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing–remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide , 2000, Journal of Neuroimmunology.
[110] L. Adorini. Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases , 1999, Cellular and Molecular Life Sciences CMLS.
[111] P. Kivisäkk,et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis , 1999, Multiple sclerosis.
[112] J. Burns,et al. Isolation of myelin basic protein–specific T cells predominantly from the memory T‐cell compartment in multiple sclerosis , 1999, Annals of neurology.
[113] G. Trinchieri,et al. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. , 1998, Journal of immunology.
[114] A. Billiau,et al. Immunomodulatory Properties of Interferon‐γ: An Update a , 1998 .
[115] H. Weiner,et al. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. , 1998, The Journal of clinical investigation.
[116] S. Akira,et al. Defective NK cell activity and Th1 response in IL-18-deficient mice. , 1998, Immunity.
[117] E. Shevach,et al. An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease , 1998, The Journal of experimental medicine.
[118] C. June,et al. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. , 1998 .
[119] E. Kieff,et al. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[120] J. Smith,et al. Brachyury and the T-box genes. , 1997, Current opinion in genetics & development.
[121] V. Papaioannou. T-box family reunion. , 1997, Trends in genetics : TIG.
[122] S. Szabo,et al. Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells , 1997, The Journal of experimental medicine.
[123] H. Weiner,et al. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[124] H. Yang,et al. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[125] Kenneth M. Murphy,et al. Functional diversity of helper T lymphocytes , 1996, Nature.
[126] W. Cowden,et al. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. , 1996, Journal of immunology.
[127] A. Billiau,et al. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon‐γ , 1996, European journal of immunology.
[128] E. Shevach,et al. IL-12 unmasks latent autoimmune disease in resistant mice , 1996, The Journal of experimental medicine.
[129] P. Doherty,et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells , 1996, Nature.
[130] M. Kaplan,et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.
[131] D. Carvajal,et al. IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses , 1996 .
[132] K. Murphy,et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation , 1996, The Journal of experimental medicine.
[133] R. Schreiber,et al. Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway , 1996, Cell.
[134] E. Kieff,et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes , 1996, Journal of virology.
[135] J. Leonard,et al. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. , 1996, The American journal of pathology.
[136] L. Steinman,et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). , 1996, Journal of immunology.
[137] D. Hafler,et al. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions , 1995, The Journal of experimental medicine.
[138] H. Okamura,et al. Cloning of a new cytokine that induces IFN-γ production by T cells , 1995, Nature.
[139] L. Adorini,et al. The role of IL-12 in the induction of organ-specific autoimmune diseases. , 1995, Immunology today.
[140] S. Szabo,et al. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4 , 1995, The Journal of experimental medicine.
[141] P. Albert,et al. Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. , 1995, Journal of immunology.
[142] J. Leonard,et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12 , 1995, The Journal of experimental medicine.
[143] E. Shevach,et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. , 1994 .
[144] R. Flavell,et al. The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells , 1993, Cell.
[145] A. Sher,et al. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[146] M. Cuzner,et al. Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization. , 1993, Cytokine.
[147] M. Jensen,et al. Interferon γ- and interleukin-4-secreting cells in multiple sclerosis , 1993, Journal of Neuroimmunology.
[148] G. Trinchieri,et al. Interleukin-12 and its role in the generation of TH1 cells. , 1993, Immunology today.
[149] A. Sher,et al. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[150] C. Hsieh,et al. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. , 1993, Science.
[151] E. Unanue,et al. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[152] G. Trinchieri,et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells , 1993, The Journal of experimental medicine.
[153] C. Janeway,et al. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma , 1993, The Journal of experimental medicine.
[154] C. March,et al. Molecular cloning of the interleukin-1 beta converting enzyme. , 1992, Science.
[155] M. de Carli,et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. , 1992, Journal of immunology.
[156] J. Saurat,et al. A common precursor for CD4+ T cells producing IL-2 or IL-4. , 1992, Journal of immunology.
[157] F. Finkelman,et al. Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse , 1992, Journal of Neuroimmunology.
[158] P. Scott. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. , 1991, Journal of immunology.
[159] F. Podlaski,et al. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). , 1991, Journal of immunology.
[160] M. Goldman,et al. TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. , 1991, Immunology today.
[161] T. Olsson,et al. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls , 1991, European journal of immunology.
[162] P. Familletti,et al. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[163] T. Olsson,et al. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. , 1990, The Journal of clinical investigation.
[164] A. Poustka,et al. Cloning of the T gene required in mesoderm formation in the mouse , 1990, Nature.
[165] R J Albertini,et al. T cells responsive to myelin basic protein in patients with multiple sclerosis. , 1990, Science.
[166] E. Sercarz,et al. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. , 1989, Cellular immunology.
[167] G. Trinchieri,et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes , 1989, Journal of Experimental Medicine.
[168] H. Kirchner,et al. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? , 1988, Acta neurologica Scandinavica.
[169] R. Swanborg,et al. Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis. , 1988, Journal of immunology.
[170] R. Hirsch,et al. Treatment of multiple sclerosis with gamma interferon , 1987, Neurology.
[171] R. Hirsch,et al. EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON , 1987, The Lancet.
[172] R. Coffman,et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.
[173] M. Meisler. Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease , 2009, Mammalian Genome.
[174] Yongwon Choi,et al. An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells , 2004, Nature Immunology.
[175] U. Christen,et al. Manipulating the type 1 vs type 2 balance in type 1 diabetes , 2004, Immunologic research.
[176] Jianfei Yang,et al. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells , 2002, Nature Immunology.
[177] G. Trinchieri,et al. Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. , 2001, Clinical immunology.
[178] C. Karp,et al. Interferon β in multiple sclerosis: is IL-12 suppression the key? , 2000 .
[179] W. Ouyang,et al. Signaling and transcription in T helper development. , 2000, Annual review of immunology.
[180] L Adorini,et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. , 1998, Annual review of immunology.
[181] J. Leonard,et al. Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12. , 1997, Critical reviews in immunology.
[182] W. Paul,et al. Acquisition of lymphokine-producing phenotype by CD4+ T cells. , 1994, Annual review of immunology.
[183] H. McFarland,et al. T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. , 1993, Autoimmunity.
[184] R. Knobler,et al. Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis. , 1993, Autoimmunity.
[185] D. McFarlin,et al. Immunological aspects of demyelinating diseases. , 1992, Annual review of immunology.
[186] R. Coffman,et al. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.