Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis

[1]  Yuhong Yang,et al.  TGF-β Enhances Effector Th1 Cell Activation but Promotes Self-Regulation via IL-10 , 2010, The Journal of Immunology.

[2]  Eva Tolosa,et al.  Phenotypical Characterization of Human Th17 Cells Unambiguously Identified by Surface IL-17A Expression1 , 2009, The Journal of Immunology.

[3]  T. Pekmezović,et al.  Expression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment? , 2009, Journal of Neuroimmunology.

[4]  Lionel B Ivashkiv,et al.  Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. , 2009, Immunity.

[5]  P. Duquette,et al.  Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis , 2009, Annals of neurology.

[6]  K. Mills,et al.  Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. , 2009, Immunity.

[7]  Yuhong Yang,et al.  T-bet is essential for encephalitogenicity of both Th1 and Th17 cells , 2009, The Journal of experimental medicine.

[8]  D. Unutmaz RORC2: The master of human Th17 cell programming , 2009, European journal of immunology.

[9]  M. Levings,et al.  The role of retinoic acid‐related orphan receptor variant 2 and IL‐17 in the development and function of human CD4+ T cells , 2009, European journal of immunology.

[10]  D. Littman,et al.  Plasticity of CD4+ T cell lineage differentiation. , 2009, Immunity.

[11]  Gary D. Stormo,et al.  The AP-1 transcription factor Batf controls TH17 differentiation , 2009, Nature.

[12]  V. Kuchroo,et al.  Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells1 , 2009, The Journal of Immunology.

[13]  Danila Valmori,et al.  Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt , 2009, Proceedings of the National Academy of Sciences.

[14]  A. Adamson,et al.  The Current STATus of lymphocyte signaling: new roles for old players. , 2009, Current opinion in immunology.

[15]  D. Littman,et al.  Identification of IL-17-producing FOXP3+ regulatory T cells in humans , 2009, Proceedings of the National Academy of Sciences.

[16]  M. Racke,et al.  Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis? , 2009, Expert review of neurotherapeutics.

[17]  C. Elson,et al.  Late developmental plasticity in the T helper 17 lineage. , 2009, Immunity.

[18]  B. Becher,et al.  IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. , 2008, The Journal of clinical investigation.

[19]  D. Vignali,et al.  Interleukin‐35: odd one out or part of the family? , 2008, Immunological reviews.

[20]  L. Cosmi,et al.  The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. , 2008, International immunology.

[21]  Warren Strober,et al.  Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells , 2008, Nature Immunology.

[22]  Hyun-Dong Chang,et al.  Th memory for interleukin‐17 expression is stable in vivo , 2008, European journal of immunology.

[23]  P. Rutgeerts,et al.  A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. , 2008, Gastroenterology.

[24]  Irma Joosten,et al.  Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. , 2008, Blood.

[25]  C. Constantinescu,et al.  Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study , 2008, The Lancet Neurology.

[26]  L. Cosmi,et al.  Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor , 2008, The Journal of experimental medicine.

[27]  B. Segal,et al.  IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition , 2008, The Journal of experimental medicine.

[28]  David E. Anderson,et al.  IL-21 and TGF-β are required for differentiation of human TH17 cells , 2008, Nature.

[29]  Jianfei Yang,et al.  Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells , 2008, European journal of immunology.

[30]  R. Meier,et al.  IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity in vivo , 2008, European journal of immunology.

[31]  A. Yoshimura,et al.  Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*♦ , 2008, Journal of Biological Chemistry.

[32]  A. Kimball,et al.  Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1) , 2008, The Lancet.

[33]  D. Littman,et al.  The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt , 2008, Nature Immunology.

[34]  H. Weiner,et al.  Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor , 2008, Nature.

[35]  J. Buer,et al.  The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins , 2008, Nature.

[36]  Yuelei Shen,et al.  TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function , 2008, Nature.

[37]  J. Goverman,et al.  Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells , 2008, Nature Medicine.

[38]  E. Wawrousek,et al.  Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells1 , 2008, The Journal of Immunology.

[39]  Guang-Xian Zhang,et al.  Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. , 2008, Experimental and molecular pathology.

[40]  Chen Dong,et al.  T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. , 2008, Immunity.

[41]  J. Farber,et al.  Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR61 , 2008, The Journal of Immunology.

[42]  Lai Wei,et al.  IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner* , 2007, Journal of Biological Chemistry.

[43]  K. Boyd,et al.  The inhibitory cytokine IL-35 contributes to regulatory T-cell function , 2007, Nature.

[44]  Graham M Lord,et al.  Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes , 2007, Proceedings of the National Academy of Sciences.

[45]  Nathalie Arbour,et al.  Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation , 2007, Nature Medicine.

[46]  Roland Martin,et al.  Multiple sclerosis: a complicated picture of autoimmunity , 2007, Nature Immunology.

[47]  T. Mak,et al.  The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 , 2007, Nature Immunology.

[48]  D. Levy,et al.  IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways , 2007, Nature Immunology.

[49]  Kathleen M. Smith,et al.  Development, cytokine profile and function of human interleukin 17–producing helper T cells , 2007, Nature Immunology.

[50]  L. Cosmi,et al.  Phenotypic and functional features of human Th17 cells , 2007, The Journal of experimental medicine.

[51]  F. Sallusto,et al.  Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells , 2007, Nature Immunology.

[52]  Terry B. Strom,et al.  IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells , 2007, Nature.

[53]  A. D. Panopoulos,et al.  Essential autocrine regulation by IL-21 in the generation of inflammatory T cells , 2007, Nature.

[54]  D. Jarrossay,et al.  Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells , 2007, Nature Immunology.

[55]  D. G. Zisoulis,et al.  Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1 , 2007, The Journal of Immunology.

[56]  Chen Dong,et al.  STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells* , 2007, Journal of Biological Chemistry.

[57]  L. Hennighausen,et al.  Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.

[58]  J. Leonard,et al.  IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis , 2007, The Journal of Immunology.

[59]  Guang-Xian Zhang,et al.  Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. , 2007, Brain : a journal of neurology.

[60]  A. Lovett-racke,et al.  T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity1 , 2007, The Journal of Immunology.

[61]  D. Littman,et al.  The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.

[62]  K. Honda,et al.  IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors , 2006, Nature Reviews Immunology.

[63]  K. Honda,et al.  Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors , 2006 .

[64]  K. Mills,et al.  A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis , 2006, The Journal of experimental medicine.

[65]  Shailendra Giri,et al.  T‐bet is essential for the progression of experimental autoimmune encephalomyelitis , 2006, Immunology.

[66]  H. Weiner,et al.  IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production , 2006, The Journal of Immunology.

[67]  L. Hennighausen,et al.  Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[68]  H. Weiner,et al.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.

[69]  L. Presta,et al.  Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. , 2006, The Journal of clinical investigation.

[70]  R. J. Hocking,et al.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. , 2006, Immunity.

[71]  R. D. Hatton,et al.  Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages , 2005, Nature Immunology.

[72]  R. Hintzen,et al.  Suppression of Ongoing Disease in a Nonhuman Primate Model of Multiple Sclerosis by a Human-Anti-Human IL-12p40 Antibody1 , 2005, The Journal of Immunology.

[73]  T. Mak,et al.  Roles of interferon-regulatory factors in T-helper-cell differentiation , 2005, Nature Reviews Immunology.

[74]  T. Mcclanahan,et al.  IL-23 drives a pathogenic T cell population that induces autoimmune inflammation , 2005, The Journal of experimental medicine.

[75]  A. Lovett-racke,et al.  Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. , 2004, Immunity.

[76]  S. Szabo,et al.  Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis , 2004, The Journal of experimental medicine.

[77]  B. '. ’t Hart,et al.  Evaluating the validity of animal models for research into therapies for immune-based disorders. , 2004, Drug discovery today.

[78]  Peter R. Galle,et al.  Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7 , 2004, The Journal of Immunology.

[79]  Li Li,et al.  Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 , 2003, The Journal of experimental medicine.

[80]  M. Kamoun,et al.  Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia , 2003, Journal of the Neurological Sciences.

[81]  M. Kamoun,et al.  Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis 1 , 2003, The Journal of Immunology.

[82]  B. Becher,et al.  IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. , 2003, The Journal of clinical investigation.

[83]  M. Kamoun,et al.  Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System1 , 2003, The Journal of Immunology.

[84]  R. Kastelein,et al.  Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain , 2003, Nature.

[85]  A. Gurney,et al.  Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17* , 2003, The Journal of Biological Chemistry.

[86]  J. Fanzo,et al.  Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4* , 2002, The Journal of Biological Chemistry.

[87]  M. Kamoun,et al.  IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination1 , 2002, The Journal of Immunology.

[88]  B. '. ’t Hart,et al.  Prevention of Experimental Autoimmune Encephalomyelitis in Common Marmosets Using an Anti-IL-12p40 Monoclonal Antibody1 , 2002, Journal of Immunology.

[89]  T. Mak,et al.  Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[90]  B. Becher,et al.  Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. , 2002, The Journal of clinical investigation.

[91]  L. Chodosh,et al.  Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction , 2002, Nature Immunology.

[92]  T. Mcclanahan,et al.  A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1 , 2002, The Journal of Immunology.

[93]  Jorge R. Oksenberg,et al.  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis , 2002, Nature Medicine.

[94]  L. Glimcher,et al.  Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression , 2002, The Journal of experimental medicine.

[95]  S. Szabo,et al.  Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells , 2002, Science.

[96]  A. Sher,et al.  T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[97]  R. Bontrop,et al.  Non‐human primate models of multiple sclerosis , 2001, Immunological reviews.

[98]  S. Khoury,et al.  Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. , 2001, The Journal of clinical investigation.

[99]  H. Kiyono,et al.  Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). , 2001, Journal of autoimmunity.

[100]  M. Leach,et al.  Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death , 2001, The Journal of Immunology.

[101]  Andrew L. Kung,et al.  Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection , 2001, Science.

[102]  J Wagner,et al.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. , 2000, Immunity.

[103]  J. Frank,et al.  Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand , 2000, Nature Medicine.

[104]  Richard A. Rudick,et al.  Quantification of Self-Recognition in Multiple Sclerosis by Single-Cell Analysis of Cytokine Production1 , 2000, The Journal of Immunology.

[105]  L. Glimcher,et al.  Lineage commitment in the immune system: the T helper lymphocyte grows up. , 2000, Genes & development.

[106]  S. Wittmer,et al.  Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis , 2000, The Journal of experimental medicine.

[107]  A. Pierani,et al.  Requirement for RORgamma in thymocyte survival and lymphoid organ development. , 2000, Science.

[108]  Laurie H Glimcher,et al.  A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.

[109]  A. Komiyama,et al.  Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing–remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide , 2000, Journal of Neuroimmunology.

[110]  L. Adorini Interleukin-12, a key cytokine in Th1-mediated autoimmune diseases , 1999, Cellular and Molecular Life Sciences CMLS.

[111]  P. Kivisäkk,et al.  Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis , 1999, Multiple sclerosis.

[112]  J. Burns,et al.  Isolation of myelin basic protein–specific T cells predominantly from the memory T‐cell compartment in multiple sclerosis , 1999, Annals of neurology.

[113]  G. Trinchieri,et al.  Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. , 1998, Journal of immunology.

[114]  A. Billiau,et al.  Immunomodulatory Properties of Interferon‐γ: An Update a , 1998 .

[115]  H. Weiner,et al.  Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. , 1998, The Journal of clinical investigation.

[116]  S. Akira,et al.  Defective NK cell activity and Th1 response in IL-18-deficient mice. , 1998, Immunity.

[117]  E. Shevach,et al.  An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease , 1998, The Journal of experimental medicine.

[118]  C. June,et al.  Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. , 1998 .

[119]  E. Kieff,et al.  Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[120]  J. Smith,et al.  Brachyury and the T-box genes. , 1997, Current opinion in genetics & development.

[121]  V. Papaioannou T-box family reunion. , 1997, Trends in genetics : TIG.

[122]  S. Szabo,et al.  Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells , 1997, The Journal of experimental medicine.

[123]  H. Weiner,et al.  Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[124]  H. Yang,et al.  A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[125]  Kenneth M. Murphy,et al.  Functional diversity of helper T lymphocytes , 1996, Nature.

[126]  W. Cowden,et al.  IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. , 1996, Journal of immunology.

[127]  A. Billiau,et al.  Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon‐γ , 1996, European journal of immunology.

[128]  E. Shevach,et al.  IL-12 unmasks latent autoimmune disease in resistant mice , 1996, The Journal of experimental medicine.

[129]  P. Doherty,et al.  Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells , 1996, Nature.

[130]  M. Kaplan,et al.  Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.

[131]  D. Carvajal,et al.  IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses , 1996 .

[132]  K. Murphy,et al.  Reversibility of T helper 1 and 2 populations is lost after long-term stimulation , 1996, The Journal of experimental medicine.

[133]  R. Schreiber,et al.  Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway , 1996, Cell.

[134]  E. Kieff,et al.  A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes , 1996, Journal of virology.

[135]  J. Leonard,et al.  Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. , 1996, The American journal of pathology.

[136]  L. Steinman,et al.  Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). , 1996, Journal of immunology.

[137]  D. Hafler,et al.  Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions , 1995, The Journal of experimental medicine.

[138]  H. Okamura,et al.  Cloning of a new cytokine that induces IFN-γ production by T cells , 1995, Nature.

[139]  L. Adorini,et al.  The role of IL-12 in the induction of organ-specific autoimmune diseases. , 1995, Immunology today.

[140]  S. Szabo,et al.  Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4 , 1995, The Journal of experimental medicine.

[141]  P. Albert,et al.  Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. , 1995, Journal of immunology.

[142]  J. Leonard,et al.  Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12 , 1995, The Journal of experimental medicine.

[143]  E. Shevach,et al.  Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. , 1994 .

[144]  R. Flavell,et al.  The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells , 1993, Cell.

[145]  A. Sher,et al.  Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[146]  M. Cuzner,et al.  Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization. , 1993, Cytokine.

[147]  M. Jensen,et al.  Interferon γ- and interleukin-4-secreting cells in multiple sclerosis , 1993, Journal of Neuroimmunology.

[148]  G. Trinchieri,et al.  Interleukin-12 and its role in the generation of TH1 cells. , 1993, Immunology today.

[149]  A. Sher,et al.  Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[150]  C. Hsieh,et al.  Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. , 1993, Science.

[151]  E. Unanue,et al.  Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[152]  G. Trinchieri,et al.  Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells , 1993, The Journal of experimental medicine.

[153]  C. Janeway,et al.  Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma , 1993, The Journal of experimental medicine.

[154]  C. March,et al.  Molecular cloning of the interleukin-1 beta converting enzyme. , 1992, Science.

[155]  M. de Carli,et al.  Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. , 1992, Journal of immunology.

[156]  J. Saurat,et al.  A common precursor for CD4+ T cells producing IL-2 or IL-4. , 1992, Journal of immunology.

[157]  F. Finkelman,et al.  Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse , 1992, Journal of Neuroimmunology.

[158]  P. Scott IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. , 1991, Journal of immunology.

[159]  F. Podlaski,et al.  Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). , 1991, Journal of immunology.

[160]  M. Goldman,et al.  TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. , 1991, Immunology today.

[161]  T. Olsson,et al.  Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls , 1991, European journal of immunology.

[162]  P. Familletti,et al.  Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[163]  T. Olsson,et al.  Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. , 1990, The Journal of clinical investigation.

[164]  A. Poustka,et al.  Cloning of the T gene required in mesoderm formation in the mouse , 1990, Nature.

[165]  R J Albertini,et al.  T cells responsive to myelin basic protein in patients with multiple sclerosis. , 1990, Science.

[166]  E. Sercarz,et al.  Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. , 1989, Cellular immunology.

[167]  G. Trinchieri,et al.  Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes , 1989, Journal of Experimental Medicine.

[168]  H. Kirchner,et al.  Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? , 1988, Acta neurologica Scandinavica.

[169]  R. Swanborg,et al.  Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis. , 1988, Journal of immunology.

[170]  R. Hirsch,et al.  Treatment of multiple sclerosis with gamma interferon , 1987, Neurology.

[171]  R. Hirsch,et al.  EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON , 1987, The Lancet.

[172]  R. Coffman,et al.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. , 1986, Journal of immunology.

[173]  M. Meisler Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease , 2009, Mammalian Genome.

[174]  Yongwon Choi,et al.  An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells , 2004, Nature Immunology.

[175]  U. Christen,et al.  Manipulating the type 1 vs type 2 balance in type 1 diabetes , 2004, Immunologic research.

[176]  Jianfei Yang,et al.  T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells , 2002, Nature Immunology.

[177]  G. Trinchieri,et al.  Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. , 2001, Clinical immunology.

[178]  C. Karp,et al.  Interferon β in multiple sclerosis: is IL-12 suppression the key? , 2000 .

[179]  W. Ouyang,et al.  Signaling and transcription in T helper development. , 2000, Annual review of immunology.

[180]  L Adorini,et al.  The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. , 1998, Annual review of immunology.

[181]  J. Leonard,et al.  Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12. , 1997, Critical reviews in immunology.

[182]  W. Paul,et al.  Acquisition of lymphokine-producing phenotype by CD4+ T cells. , 1994, Annual review of immunology.

[183]  H. McFarland,et al.  T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. , 1993, Autoimmunity.

[184]  R. Knobler,et al.  Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis. , 1993, Autoimmunity.

[185]  D. McFarlin,et al.  Immunological aspects of demyelinating diseases. , 1992, Annual review of immunology.

[186]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.