Graphene‐Based Materials for Implants

Copyright: 2019 Scrivener Publishing LLC. This is the pre-print version of the work (Chapter 5 of volume 7 in the series "Handbook of Graphene"). For the published version, please contact the publisher's website.

[1]  Shantikumar V. Nair,et al.  Comparative in vivo toxicity, organ biodistribution and immune response of pristine, carboxylated and PEGylated few-layer graphene sheets in Swiss albino mice: A three month study , 2015 .

[2]  Yumei Zhang,et al.  Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity , 2017, International journal of nanomedicine.

[3]  Serge Picaud,et al.  Purified Neurons can Survive on Peptide‐Free Graphene Layers , 2013, Advanced healthcare materials.

[4]  M. Hasanzadeh,et al.  Graphene and its nanostructure derivatives for use in bone tissue engineering: Recent advances. , 2016, Journal of biomedical materials research. Part A.

[5]  Debabrata Dash,et al.  Amine-modified graphene: thrombo-protective safer alternative to graphene oxide for biomedical applications. , 2012, ACS nano.

[6]  Tsukasa Akasaka,et al.  Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide , 2014, International journal of nanomedicine.

[7]  Qing Huang,et al.  Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection , 2014, International journal of nanomedicine.

[8]  P. Yelick,et al.  Accurately shaped tooth bud cell-derived mineralized tissue formation on silk scaffolds. , 2008, Tissue engineering. Part A.

[9]  Lidong Li,et al.  Facile one-step synthesis of a 3D macroscopic SnO2–graphene aerogel and its application as a superior anode material for Li-ion batteries , 2013 .

[10]  Abhilash Sasidharan,et al.  Confocal Raman Imaging Study Showing Macrophage Mediated Biodegradation of Graphene In Vivo , 2013, Advanced healthcare materials.

[11]  L. Lipińska,et al.  Long Term Influence of Carbon Nanoparticles on Health and Liver Status in Rats , 2015, PloS one.

[12]  Hui Liu,et al.  Graphene oxide as a matrix for enzyme immobilization. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[13]  Balaji Sitharaman,et al.  Toxicology of graphene-based nanomaterials. , 2016, Advanced drug delivery reviews.

[14]  R. Car,et al.  Oxygen-driven unzipping of graphitic materials. , 2006, Physical review letters.

[15]  He Shen,et al.  Assessing in vivo toxicity of graphene materials: current methods and future outlook. , 2014, Nanomedicine.

[16]  Jian-hui Jiang,et al.  Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection. , 2010, Analytical chemistry.

[17]  U. Hashim,et al.  Nanogapped impedimetric immunosensor for the detection of 16 kDa heat shock protein against Mycobacterium tuberculosis , 2016, Microchimica Acta.

[18]  Oscar N. Ruiz,et al.  Graphene oxide: a nonspecific enhancer of cellular growth. , 2011, ACS nano.

[19]  Chwee Teck Lim,et al.  Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide. , 2011, ACS nano.

[20]  Ping Wang,et al.  Macroscopic multifunctional graphene-based hydrogels and aerogels by a metal ion induced self-assembly process. , 2012, ACS nano.

[21]  L. Lipińska,et al.  Graphene Functionalized with Arginine Decreases the Development of Glioblastoma Multiforme Tumor in a Gene-Dependent Manner , 2015, International journal of molecular sciences.

[22]  Xuping Sun,et al.  Biomolecule-assisted synthesis of nickel sulfides/reduced graphene oxide nanocomposites as electrode materials for supercapacitors , 2013 .

[23]  Chao Zhang,et al.  One‐Step Ionic‐Liquid‐Assisted Electrochemical Synthesis of Ionic‐Liquid‐Functionalized Graphene Sheets Directly from Graphite , 2008 .

[24]  R. Advíncula,et al.  Graphene nanocomposite for biomedical applications: fabrication, antimicrobial and cytotoxic investigations , 2012, Nanotechnology.

[25]  A. Hirsch The era of carbon allotropes. , 2010, Nature materials.

[26]  Sanjay Mathur,et al.  Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells. , 2013, Small.

[27]  X. Qu,et al.  Colorimetric Biosensing Using Smart Materials , 2011, Advanced materials.

[28]  Ming Zhou,et al.  Controlled synthesis of large-area and patterned electrochemically reduced graphene oxide films. , 2009, Chemistry.

[29]  R. Pallela,et al.  Applications of carbon nanomaterials in bone tissue engineering. , 2014, Journal of biomedical nanotechnology.

[30]  Kostas Kostarelos,et al.  Tissue distribution and urinary excretion of intravenously administered chemically functionalized graphene oxide sheets† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00114e , 2015, Chemical science.

[31]  Xuanyong Liu,et al.  Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing. , 2018, Biomaterials science.

[32]  Mark H. Wilson Electrons in atomically thin carbon sheets behave like massless particles , 2006 .

[33]  Shaojun Guo,et al.  Graphene nanosheet: synthesis, molecular engineering, thin film, hybrids, and energy and analytical applications. , 2011, Chemical Society reviews.

[34]  Yanli Chang,et al.  Effect of size and dose on the biodistribution of graphene oxide in mice. , 2012, Nanomedicine.

[35]  P. J. Ollivier,et al.  Layer-by-Layer Assembly of Ultrathin Composite Films from Micron-Sized Graphite Oxide Sheets and Polycations , 1999 .

[36]  S. Dong,et al.  Label-free aptamer biosensor for thrombin detection based on functionalized graphene nanocomposites. , 2015, Talanta.

[37]  A. H. Castro Neto,et al.  Graphene oxide-based substrate: physical and surface characterization, cytocompatibility and differentiation potential of dental pulp stem cells. , 2016, Dental materials : official publication of the Academy of Dental Materials.

[38]  S. Kanakia,et al.  The effects of graphene nanostructures on mesenchymal stem cells. , 2014, Biomaterials.

[39]  M. Collado-González,et al.  Silk-Fibroin and Graphene Oxide Composites Promote Human Periodontal Ligament Stem Cell Spontaneous Differentiation into Osteo/Cementoblast-Like Cells. , 2016, Stem cells and development.

[40]  Dong Yun Lee,et al.  In vivo biodistribution and toxicology of carboxylated graphene quantum dots. , 2013, ACS nano.

[41]  Chang-Sik Ha,et al.  Synthesis and Drug‐Delivery Behavior of Chitosan‐Functionalized Graphene Oxide Hybrid Nanosheets , 2011 .

[42]  E. Borowiak‐Palen,et al.  Synthesis, dispersion, and cytocompatibility of graphene oxide and reduced graphene oxide. , 2012, Colloids and surfaces. B, Biointerfaces.

[43]  Francisco J. Arregui,et al.  Optical Fibre Sensors Using Graphene-Based Materials: A Review , 2017, Sensors.

[44]  U. Hashim,et al.  Aptamer-based impedimetric determination of the human blood clotting factor IX in serum using an interdigitated electrode modified with a ZnO nanolayer , 2016, Microchimica Acta.

[45]  Kai Yang,et al.  In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration. , 2013, Biomaterials.

[46]  Ying Wang,et al.  Application of graphene-modified electrode for selective detection of dopamine , 2009 .

[47]  Graphene- An emerging star in the field of nanotechnology , 2016 .

[48]  Bing Yan,et al.  Size-dependent cell uptake of protein-coated graphene oxide nanosheets. , 2012, ACS applied materials & interfaces.

[49]  R. Misra,et al.  Controlled release of drug from folate-decorated and graphene mediated drug delivery system: Synthesis, loading efficiency, and drug release response , 2011 .

[50]  R. Zhuo,et al.  Graphene-based anticancer nanosystem and its biosafety evaluation using a zebrafish model. , 2013, Biomacromolecules.

[51]  C. N. Lau,et al.  Superior thermal conductivity of single-layer graphene. , 2008, Nano letters.

[52]  F. Guinea,et al.  The electronic properties of graphene , 2007, Reviews of Modern Physics.

[53]  J. Anzai,et al.  Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review , 2017, Molecules.

[54]  S. Shrivastava,et al.  Thrombus inducing property of atomically thin graphene oxide sheets. , 2011, ACS nano.

[55]  Hui‐Ming Cheng,et al.  The reduction of graphene oxide , 2012 .

[56]  Kotaro Kajikawa,et al.  Label and Label-Free Detection Techniques for Protein Microarrays , 2015, Microarrays.

[57]  Kun Wang,et al.  Fluorescent "on-off-on" switching sensor based on CdTe quantum dots coupled with multiwalled carbon nanotubes@graphene oxide nanoribbons for simultaneous monitoring of dual foreign DNAs in transgenic soybean. , 2017, Biosensors & bioelectronics.

[58]  O. Akhavan,et al.  Accelerated differentiation of neural stem cells into neurons on ginseng-reduced graphene oxide sheets , 2014 .

[59]  A. Sbarbati,et al.  Neuronal differentiation potential of human adipose-derived mesenchymal stem cells. , 2008, Stem cells and development.

[60]  Hanna Trzeciakiewicz,et al.  A protein-based electrochemical biosensor for detection of tau protein, a neurodegenerative disease biomarker. , 2014, The Analyst.

[61]  Donald R. Peterson,et al.  Biomaterials : principles and practices , 2012 .

[62]  A. M. van der Zande,et al.  Impermeable atomic membranes from graphene sheets. , 2008, Nano letters.

[63]  Bei Wang,et al.  FACILE SYNTHESIS AND CHARACTERIZATION OF GRAPHENE NANOSHEETS , 2008 .

[64]  D. Rodrigues,et al.  Toxicity of a polymer-graphene oxide composite against bacterial planktonic cells, biofilms, and mammalian cells. , 2012, Nanoscale.

[65]  S. Khondaker,et al.  Oxygenated Functional Group Density on Graphene Oxide: Its Effect on Cell Toxicity , 2013 .

[66]  H. Ju,et al.  Fluorescence resonance energy transfer between quantum dots and graphene oxide for sensing biomolecules. , 2010, Analytical chemistry.

[67]  Inhwa Jung,et al.  Colloidal suspensions of highly reduced graphene oxide in a wide variety of organic solvents. , 2009, Nano letters.

[68]  H. Hong,et al.  A new role of substance P as an injury-inducible messenger for mobilization of CD29+ stromal-like cells , 2009, Nature Medicine.

[69]  Intekhab Islam,et al.  Graphene: A Versatile Carbon-Based Material for Bone Tissue Engineering , 2015, Stem cells international.

[70]  Hiroshi Sagara,et al.  Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering. , 2006, Biomaterials.

[71]  Xinyan Tracy Cui,et al.  Directed Neural Stem Cell Differentiation with a Functionalized Graphene Oxide Nanocomposite , 2015, Advanced healthcare materials.

[72]  P. Ajayan,et al.  Blue photoluminescent carbon nanodots from limeade. , 2016, Materials science & engineering. C, Materials for biological applications.

[73]  Jinghua Yu,et al.  Growth and accelerated differentiation of mesenchymal stem cells on graphene-oxide-coated titanate with dexamethasone on surface of titanium implants. , 2017, Dental materials : official publication of the Academy of Dental Materials.

[74]  L. Amelse,et al.  Graphene supports in vitro proliferation and osteogenic differentiation of goat adult mesenchymal stem cells: potential for bone tissue engineering , 2015, Journal of applied toxicology : JAT.

[75]  He Shen,et al.  Biomedical Applications of Graphene , 2012, Theranostics.

[76]  Seok‐In Na,et al.  Moderately reduced graphene oxide as transparent counter electrodes for dye-sensitized solar cells , 2012 .

[77]  R. Young,et al.  The real graphene oxide revealed: stripping the oxidative debris from the graphene-like sheets. , 2011, Angewandte Chemie.

[78]  Pgdhhm Neeraj Malhotra Mds,et al.  Regenerative endodontics as a tissue engineering approach: Past, current and future , 2012 .

[79]  Evangelyn C. Alocilja,et al.  Market Analysis of Biosensors for Food Safety , 2002 .

[80]  Zhuoxuan Lu,et al.  Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. , 2011, Small.

[81]  Joseph C Liao,et al.  Advances and challenges in biosensor-based diagnosis of infectious diseases , 2014, Expert review of molecular diagnostics.

[82]  R. Ruoff,et al.  Graphene and Graphene Oxide: Synthesis, Properties, and Applications , 2010, Advanced materials.

[83]  Ata Mahjoubfar,et al.  Deep Learning in Label-free Cell Classification , 2016, Scientific Reports.

[84]  S. Stankovich,et al.  Graphene-based composite materials , 2006, Nature.

[85]  Jinghong Li,et al.  Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS. , 2010, Analytical chemistry.

[86]  Bei Wang,et al.  Synthesis and characterisation of hydrophilic and organophilic graphene nanosheets , 2009 .

[87]  Dan Li,et al.  Ordered gelation of chemically converted graphene for next-generation electroconductive hydrogel films. , 2011, Angewandte Chemie.

[88]  Yuehe Lin,et al.  Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells. , 2010, Journal of the American Chemical Society.

[89]  Moon Gyu Sung,et al.  Enhanced Differentiation of Human Neural Stem Cells into Neurons on Graphene , 2011, Advanced materials.

[90]  J. Guo,et al.  The Effect of Thermal Reduction on the Photoluminescence and Electronic Structures of Graphene Oxides , 2014, Scientific Reports.

[91]  A. Bianco,et al.  Graphene-based nanomaterials for nanobiotechnology and biomedical applications. , 2013, Nanomedicine.

[92]  Sook Hee Ku,et al.  Graphene–Biomineral Hybrid Materials , 2011, Advanced materials.

[93]  H. Mouridsen,et al.  Doxorubicin versus methotrexate both combined with cyclophosphamide, 5-fluorouracil and tamoxifen in postmenopausal patients with advanced breast cancer--a randomised study with more than 10 years follow-up from the Danish Breast Cancer Cooperative Group. Danish Breast Cancer Cooperative Group (DBCG , 1999, European journal of cancer.

[94]  Xiao Zhi,et al.  The immunotoxicity of graphene oxides and the effect of PVP-coating. , 2013, Biomaterials.

[95]  Jinghong Li,et al.  Efficient Analysis of Non-Polar Environmental Contaminants by MALDI-TOF MS with Graphene as Matrix , 2011, Journal of the American Society for Mass Spectrometry.

[96]  Li Wang,et al.  Prussian blue nanocubes on nitrobenzene-functionalized reduced graphene oxide and its application for H2O2 biosensing , 2013 .

[97]  Y. Nagasaki,et al.  Co-immobilized poly(ethylene glycol)-block-polyamines promote sensitivity and restrict biofouling on gold sensor surface for detecting factor IX in human plasma. , 2014, The Analyst.

[98]  Nikhil V. Medhekar,et al.  Stability and formation mechanisms of carbonyl- and hydroxyl-decorated holes in graphene oxide , 2010 .

[99]  Chang Ming Li,et al.  Aptamer based fluorescence recovery assay for aflatoxin B1 using a quencher system composed of quantum dots and graphene oxide , 2015, Microchimica Acta.

[100]  Kai Yang,et al.  In vitro and in vivo behaviors of dextran functionalized graphene , 2011 .

[101]  Jae-Hong Kim,et al.  3D hydrogel scaffold doped with 2D graphene materials for biosensors and bioelectronics. , 2017, Biosensors & bioelectronics.

[102]  K. Char,et al.  Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration , 2014, International journal of nanomedicine.

[103]  Ping Wu,et al.  Aptamer-functionalized graphene oxide for highly efficient loading and cancer cell-specific delivery of antitumor drug. , 2014, Journal of materials chemistry. B.

[104]  D. García-Bernal,et al.  Effects of composite films of silk fibroin and graphene oxide on the proliferation, cell viability and mesenchymal phenotype of periodontal ligament stem cells , 2014, Journal of Materials Science: Materials in Medicine.

[105]  Hongji Jiang Chemical preparation of graphene-based nanomaterials and their applications in chemical and biological sensors. , 2011, Small.

[106]  Yingfu Li,et al.  Optical biosensors utilizing graphene and functional DNA molecules , 2017 .

[107]  Abhishek Sahu,et al.  A stimuli-sensitive injectable graphene oxide composite hydrogel. , 2012, Chemical communications.

[108]  S. Stankovich,et al.  Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide , 2007 .

[109]  Min Soo Bae,et al.  The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function. , 2011, Biomaterials.

[110]  Guigen Zhang Nanotechnology-Based Biosensors in Drug Delivery , 2009 .

[111]  I. Kwon,et al.  Surface modification of multipass caliber-rolled Ti alloy with dexamethasone-loaded graphene for dental applications. , 2015, ACS applied materials & interfaces.

[112]  Takashi Nakamura,et al.  Fully functional bioengineered tooth replacement as an organ replacement therapy , 2009, Proceedings of the National Academy of Sciences.

[113]  C. Fan,et al.  Protein corona-mediated mitigation of cytotoxicity of graphene oxide. , 2011, ACS nano.

[114]  Poramane Chiochan,et al.  Synthesis and antifungal activity of reduced graphene oxide nanosheets , 2012 .

[115]  Hui Jiang,et al.  Gold nanoclusters and graphene nanocomposites for drug delivery and imaging of cancer cells. , 2011, Angewandte Chemie.

[116]  Wei Wang,et al.  Biological applications of carbon dots , 2014, Science China Chemistry.

[117]  Kai Yang,et al.  In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice. , 2011, ACS nano.

[118]  Sarnjeet S. Dhesi,et al.  Catalyst‐Free Efficient Growth, Orientation and Biosensing Properties of Multilayer Graphene Nanoflake Films with Sharp Edge Planes , 2008 .

[119]  Andre K. Geim,et al.  The rise of graphene. , 2007, Nature materials.

[120]  A. Eftekhari,et al.  Curly Graphene with Specious Interlayers Displaying Superior Capacity for Hydrogen Storage , 2013 .

[121]  M. Otyepka,et al.  Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications. , 2012, Chemical reviews.

[122]  K Kostarelos,et al.  Graphene for multi-functional synthetic biology: the last 'zeitgeist' in nanomedicine. , 2014, Bioorganic & medicinal chemistry letters.

[123]  B. Sitharaman,et al.  Structural disruption increases toxicity of graphene nanoribbons , 2014, Journal of applied toxicology : JAT.

[124]  Xin Huang,et al.  Multi-functionalized graphene oxide based anticancer drug-carrier with dual-targeting function and pH-sensitivity , 2011 .

[125]  Richard Beanland,et al.  Graphene oxide: structural analysis and application as a highly transparent support for electron microscopy. , 2009, ACS nano.

[126]  Fengjuan Chen,et al.  Biomimetic and cell-mediated mineralization of hydroxyapatite by carrageenan functionalized graphene oxide. , 2014, ACS applied materials & interfaces.

[127]  Jianfeng Shen,et al.  Mechanical, thermal and swelling properties of poly(acrylic acid)–graphene oxide composite hydrogels , 2012 .

[128]  M. Pumera,et al.  Cytotoxicity of halogenated graphenes. , 2014, Nanoscale.

[129]  Chi Cheng,et al.  Self‐Supporting Graphene Hydrogel Film as an Experimental Platform to Evaluate the Potential of Graphene for Bone Regeneration , 2013 .

[130]  Yukui Zhang,et al.  Aptamer-conjugated gold functionalized graphene oxide nanocomposites for human α-thrombin specific recognition. , 2016, Journal of chromatography. A.

[131]  Chengyu Yang,et al.  The short- and long-term effects of orally administered high-dose reduced graphene oxide nanosheets on mouse behaviors. , 2015, Biomaterials.

[132]  Hongwei Ma,et al.  Facile synthesis and application of Ag-chemically converted graphene nanocomposite , 2010 .

[133]  Bunshi Fugetsu,et al.  Graphene phytotoxicity in the seedling stage of cabbage, tomato, red spinach, and lettuce , 2011 .

[134]  Suck Won Hong,et al.  Reduced graphene oxide-coated hydroxyapatite composites stimulate spontaneous osteogenic differentiation of human mesenchymal stem cells. , 2015, Nanoscale.

[135]  O. Muskens,et al.  Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer's Disease and Prostate Cancer. , 2017, ACS sensors.

[136]  P. Ming,et al.  Ab initio calculation of ideal strength and phonon instability of graphene under tension , 2007 .

[137]  G. Pastorin,et al.  Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. , 2011, ACS nano.

[138]  P. Yelick,et al.  Bioengineered Teeth from Cultured Rat Tooth Bud Cells , 2004, Journal of dental research.

[139]  W. N. Chen,et al.  Cytotoxicity evaluation of oxidized single-walled carbon nanotubes and graphene oxide on human hepatoma HepG2 cells: an iTRAQ-coupled 2D LC-MS/MS proteome analysis. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[140]  R. Ruoff,et al.  Chemical methods for the production of graphenes. , 2009, Nature nanotechnology.

[141]  T. Rocha-Santos,et al.  Graphene based sensors and biosensors , 2017 .

[142]  Sergey Mikhailov,et al.  Physics and Applications of Graphene - Experiments , 2011 .

[143]  A. Khademhosseini,et al.  Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair , 2014, ACS nano.

[144]  Zhuo Sun,et al.  UV-assisted photocatalytic synthesis of ZnO–reduced graphene oxide composites with enhanced photocatalytic activity in reduction of Cr(VI) , 2012 .

[145]  Cuiyun Liu,et al.  Surface Modification of Graphene Oxide by Carboxyl-Group: Preparation, Characterization, and Application for Proteins Immobilization , 2015 .

[146]  Young Hee Lee,et al.  Graphene Versus Carbon Nanotubes in Electronic Devices , 2011 .

[147]  Johan Liu,et al.  The promising application of graphene oxide as coating materials in orthopedic implants: preparation, characterization and cell behavior , 2015, Biomedical materials.

[148]  I-Wei Chen,et al.  Quantum‐Dot‐Tagged Reduced Graphene Oxide Nanocomposites for Bright Fluorescence Bioimaging and Photothermal Therapy Monitored In Situ , 2012, Advanced materials.

[149]  Yuyan Shao,et al.  Graphene Based Electrochemical Sensors and Biosensors: A Review , 2010 .

[150]  Mark C Hersam,et al.  Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. , 2011, Nano letters.

[151]  Alexander L. Ivanovskii,et al.  Graphene-based and graphene-like materials , 2012 .

[152]  Lin Li,et al.  The application of graphene oxide in drug delivery , 2012, Expert opinion on drug delivery.

[153]  Jae‐Hyun Kim,et al.  Synthesis of CVD-graphene on rapidly heated copper foils. , 2014, Nanoscale.

[154]  Zhijun Zhang,et al.  Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. , 2010, Small.

[155]  D. Losic,et al.  Graphene and graphene oxide as new nanocarriers for drug delivery applications. , 2013, Acta biomaterialia.

[156]  K. Ogawa,et al.  Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket , 2016, International journal of nanomedicine.

[157]  Wei Wang,et al.  High strength graphene oxide/polyvinyl alcohol composite hydrogels , 2011 .

[158]  Zhuang Liu,et al.  PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. , 2008, Journal of the American Chemical Society.

[159]  Xingfa Gao,et al.  Unraveling Stress‐Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism , 2012, Advanced materials.

[160]  Robert H. Hurt,et al.  All in the graphene family - A recommended nomenclature for two-dimensional carbon materials , 2013 .

[161]  Kai Yang,et al.  In vivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographene. , 2012, ACS nano.

[162]  SUPARNA DUTTASINHA,et al.  Graphene: Status and Prospects , 2009, Science.

[163]  Yuehe Lin,et al.  Graphene and graphene oxide: biofunctionalization and applications in biotechnology , 2011, Trends in Biotechnology.

[164]  Suejit Pechprasarn,et al.  Graphene-Based Materials for Biosensors: A Review , 2017, Sensors.

[165]  Hui Liu,et al.  Horseradish Peroxidase Immobilized on Graphene Oxide: Physical Properties and Applications in Phenolic Compound Removal , 2010 .

[166]  Ping Wu,et al.  Real-time fluorescence assay of alkaline phosphatase in living cells using boron-doped graphene quantum dots as fluorophores. , 2017, Biosensors & bioelectronics.

[167]  L. Dai,et al.  Can graphene oxide cause damage to eyesight? , 2012, Chemical research in toxicology.

[168]  A. Star,et al.  Sweet Carbon Nanostructures: Carbohydrate Conjugates with Carbon Nanotubes and Graphene and Their Applications , 2013 .

[169]  Franklin Bien,et al.  Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics , 2017, Nature Communications.

[170]  F. Ahmed,et al.  Investigation of acute effects of graphene oxide on wastewater microbial community: a case study. , 2013, Journal of hazardous materials.

[171]  Chaenyung Cha,et al.  Controlling mechanical properties of cell-laden hydrogels by covalent incorporation of graphene oxide. , 2014, Small.

[172]  Dhifaf A Jasim,et al.  Graphene oxide derivatives for biomedical applications , 2016 .

[173]  Longhua Tang,et al.  DNA-directed self-assembly of graphene oxide with applications to ultrasensitive oligonucleotide assay. , 2011, ACS nano.

[174]  K. Shroyer,et al.  Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations. , 2014, Biomaterials.

[175]  Y. Wan,et al.  Graphene oxide sheet-mediated silver enhancement for application to electrochemical biosensors. , 2011, Analytical chemistry.

[176]  Y. Tabata,et al.  In situ tissue engineering of periodontal tissues by seeding with periodontal ligament-derived cells. , 2004, Tissue engineering.

[177]  Liang Song,et al.  Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. , 2013, Biomaterials.

[178]  Zorawar Singh,et al.  Applications and toxicity of graphene family nanomaterials and their composites. , 2016, Nanotechnology, science and applications.

[179]  Y. S. Zhang,et al.  Graphene-based materials for tissue engineering. , 2016, Advanced drug delivery reviews.

[180]  A. C. Neto,et al.  Two and three-dimensional graphene substrates to magnify osteogenic differentiation of periodontal ligament stem cells , 2015 .

[181]  S. Shany,et al.  The combined treatment of 1,25-dihydroxyvitamin D3 and a non-steroid anti-inflammatory drug is highly effective in suppressing prostate cancer cell line (LNCaP) growth. , 2005, Anticancer research.

[182]  L. Ferroni,et al.  Dental Stem Cells (DSCs): Classification and Properties , 2016 .

[183]  Da Chen,et al.  Graphene-based materials in electrochemistry. , 2010, Chemical Society reviews.

[184]  A. Star,et al.  Insight into the Mechanism of Graphene Oxide Degradation via the Photo-Fenton Reaction , 2014, The journal of physical chemistry. C, Nanomaterials and interfaces.

[185]  K. Chatterjee,et al.  Strontium eluting graphene hybrid nanoparticles augment osteogenesis in a 3D tissue scaffold. , 2015, Nanoscale.

[186]  Zhiyong Tang,et al.  Acellular Synthesis of a Human Enamel‐like Microstructure , 2006 .

[187]  Xiao-Qian Wang,et al.  Epoxy-Carbonyl Conformation of Graphene Oxides , 2016 .

[188]  Sailing He,et al.  Observation of multiphoton-induced fluorescence from graphene oxide nanoparticles and applications in in vivo functional bioimaging. , 2012, Angewandte Chemie.

[189]  A. H. Castro Neto,et al.  CVD-grown monolayer graphene induces osteogenic but not odontoblastic differentiation of dental pulp stem cells. , 2017, Dental materials : official publication of the Academy of Dental Materials.

[190]  K. Mala,et al.  Regenerative endodontics as a tissue engineering approach: past, current and future. , 2012, Australian endodontic journal : the journal of the Australian Society of Endodontology Inc.

[191]  Ken Donaldson,et al.  Graphene-based nanoplatelets: a new risk to the respiratory system as a consequence of their unusual aerodynamic properties. , 2012, ACS nano.

[192]  I. In,et al.  Blood compatible graphene/heparin conjugate through noncovalent chemistry. , 2011, Biomacromolecules.

[193]  Liangzhu Feng,et al.  Graphene in biomedicine: opportunities and challenges. , 2011, Nanomedicine.

[194]  Gang Wei,et al.  When biomolecules meet graphene: from molecular level interactions to material design and applications. , 2016, Nanoscale.

[195]  Y. Niu,et al.  Detection of circulating tumor cells in prostate cancer based on carboxylated graphene oxide modified light addressable potentiometric sensor. , 2015, Biosensors & bioelectronics.

[196]  A. Khademhosseini,et al.  Cell‐laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide , 2013, Advanced materials.

[197]  E. Samulski,et al.  Synthesis of water soluble graphene. , 2008, Nano letters.

[198]  S. Gopinath,et al.  Feasibility of graphene in biomedical applications. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[199]  Hao Hong,et al.  In vivo targeting and positron emission tomography imaging of tumor vasculature with (66)Ga-labeled nano-graphene. , 2012, Biomaterials.

[200]  Andre K. Geim,et al.  Raman spectrum of graphene and graphene layers. , 2006, Physical review letters.

[201]  B. D'Anjou,et al.  Experimental Review of Graphene , 2011, 1110.6557.

[202]  Seong Soo Kang,et al.  Enhanced regeneration of the ligament-bone interface using a poly(L-lactide-co-ε-caprolactone) scaffold with local delivery of cells/BMP-2 using a heparin-based hydrogel. , 2011, Acta biomaterialia.

[203]  Atomic Structures of Graphene, Benzene and Methane with Bond Lengths as Sums of the Single, Double and Resonance Bond Radii of Carbon , 2008, 0804.4086.

[204]  Ted Belytschko,et al.  Coupled quantum mechanical/molecular mechanical modeling of the fracture of defective carbon nanotubes and graphene sheets , 2007 .

[205]  L. Yin,et al.  Contributions of altered permeability of intestinal barrier and defecation behavior to toxicity formation from graphene oxide in nematode Caenorhabditis elegans. , 2013, Nanoscale.

[206]  Kwideok Park,et al.  Controlled release of bone morphogenetic protein (BMP)-2 from nanocomplex incorporated on hydroxyapatite-formed titanium surface. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[207]  M. Vasconcelos,et al.  Implant Stability in the Posterior Maxilla: A Controlled Clinical Trial. , 2017 .

[208]  Sabine Kuchler-Bopp,et al.  Tissue engineering of tooth crown, root, and periodontium. , 2006, Tissue engineering.

[209]  Seok Hee Kang,et al.  Enhanced Osteogenesis by Reduced Graphene Oxide/Hydroxyapatite Nanocomposites , 2015, Scientific Reports.

[210]  Hong Liu,et al.  Bioactivity of periodontal ligament stem cells on sodium titanate coated with graphene oxide , 2016, Scientific Reports.

[211]  Zhijun Zhang,et al.  Composites of aminodextran-coated Fe3O4 nanoparticles and graphene oxide for cellular magnetic resonance imaging. , 2011, ACS applied materials & interfaces.

[212]  Yang Zhang,et al.  The clinical evaluation of Iressa first-line treatment of senium advanced-stage non-small cell lung cancer , 2008 .

[213]  J. Kysar,et al.  Measurement of the Elastic Properties and Intrinsic Strength of Monolayer Graphene , 2008, Science.

[214]  Zhuang Liu,et al.  Nano-graphene oxide for cellular imaging and drug delivery , 2008, Nano research.

[215]  A. Aggeli,et al.  Self-assembling Peptide Scaffolds Promote Enamel Remineralization , 2007, Journal of dental research.

[216]  K. Novoselov,et al.  Rayleigh imaging of graphene and graphene layers. , 2007, Nano letters.

[217]  Yang Xu,et al.  Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. , 2010, ACS nano.

[218]  Shouwu Guo,et al.  Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion. , 2011, Nanoscale.

[219]  Jinsong Ding,et al.  Fluorescent sensors using DNA-functionalized graphene oxide , 2014, Analytical and Bioanalytical Chemistry.

[220]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[221]  K. Novoselov,et al.  A roadmap for graphene , 2012, Nature.

[222]  Lin Li,et al.  Water‐Soluble Poly(N‐isopropylacrylamide)–Graphene Sheets Synthesized via Click Chemistry for Drug Delivery , 2011 .

[223]  Andre K. Geim,et al.  Two-dimensional atomic crystals. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[224]  Huafeng Yang,et al.  Direct electrochemistry of glucose oxidase and biosensing for glucose based on graphene. , 2009, Analytical chemistry.

[225]  S. Shi,et al.  Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. , 2008, Journal of endodontics.

[226]  A. Khademhosseini,et al.  Regulating Cellular Behavior on Few‐Layer Reduced Graphene Oxide Films with Well‐Controlled Reduction States , 2012 .

[227]  S. Shi,et al.  SHED Differentiate into Functional Odontoblasts and Endothelium , 2010, Journal of dental research.

[228]  Lo Gorton,et al.  An Overview of the Latest Graphene-Based Sensors for Glucose Detection: the Effects of Graphene Defects , 2015 .

[229]  Wei Wei,et al.  The role of the lateral dimension of graphene oxide in the regulation of cellular responses. , 2012, Biomaterials.

[230]  Pranab Goswami,et al.  Aptamer-graphene oxide for highly sensitive dual electrochemical detection of Plasmodium lactate dehydrogenase. , 2016, Analytical biochemistry.

[231]  X. Qu,et al.  Lighting up left-handed Z-DNA: photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations , 2013, Nucleic acids research.

[232]  Andre K. Geim,et al.  Electric Field Effect in Atomically Thin Carbon Films , 2004, Science.

[233]  Abdullah M. Asiri,et al.  Graphene based materials for biomedical applications , 2013 .

[234]  J. Dai,et al.  The in vitro and in vivo toxicity of graphene quantum dots. , 2014, Biomaterials.

[235]  G. Wallace,et al.  Processable aqueous dispersions of graphene nanosheets. , 2008, Nature nanotechnology.

[236]  Jing Lyu,et al.  A fluorescence turn-on biosensor based on graphene quantum dots (GQDs) and molybdenum disulfide (MoS2) nanosheets for epithelial cell adhesion molecule (EpCAM) detection. , 2017, Biosensors & bioelectronics.

[237]  O. Akhavan,et al.  Visible light-induced photocatalytic reduction of graphene oxide by tungsten oxide thin films , 2013 .

[238]  G. Algara-Siller,et al.  Chemistry on Graphene , 2015 .

[239]  Anthony P F Turner,et al.  Biosensors: sense and sensibility. , 2013, Chemical Society reviews.

[240]  Hye Rim Cho,et al.  A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy. , 2016, Nature nanotechnology.

[241]  Sei Kwang Hahn,et al.  Nano graphene oxide–hyaluronic acid conjugate for target specific cancer drug delivery , 2014 .

[242]  Xingyi Xie,et al.  Graphene and hydroxyapatite self-assemble into homogeneous, free standing nanocomposite hydrogels for bone tissue engineering. , 2015, Nanoscale.

[243]  Jiye Shi,et al.  Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice , 2013 .

[244]  Ying Wang,et al.  Self assembly of acetylcholinesterase on a gold nanoparticles-graphene nanosheet hybrid for organophosphate pesticide detection using polyelectrolyte as a linker , 2011 .

[245]  Jiali Zhang,et al.  Reduction of graphene oxide via L-ascorbic acid. , 2010, Chemical communications.

[246]  Huafeng Yang,et al.  Water-soluble graphene covalently functionalized by biocompatible poly-L-lysine. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[247]  K. Novoselov,et al.  Exploring the Interface of Graphene and Biology , 2014, Science.

[248]  P. Kamat,et al.  TiO2-graphene nanocomposites. UV-assisted photocatalytic reduction of graphene oxide. , 2008, ACS nano.

[249]  Roberto Car,et al.  Functionalized single graphene sheets derived from splitting graphite oxide. , 2006, The journal of physical chemistry. B.

[250]  Ying Liu,et al.  The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. , 2012, Biomaterials.

[251]  Wei Gao,et al.  New insights into the structure and reduction of graphite oxide. , 2009, Nature chemistry.

[252]  K. Konishi,et al.  Bone morphogenetic protein 7 induces cementogenic differentiation of human periodontal ligament-derived mesenchymal stem cells , 2014, Odontology.

[253]  S. Sampath,et al.  Electrochemical Reduction of Oriented Graphene Oxide Films: An in Situ Raman Spectroelectrochemical Study , 2009 .

[254]  Chunhai Fan,et al.  Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration , 2011 .

[255]  F. Lin,et al.  Regeneration of dentin-pulp complex with cementum and periodontal ligament formation using dental bud cells in gelatin-chondroitin-hyaluronan tri-copolymer scaffold in swine. , 2008, Journal of biomedical materials research. Part A.

[256]  R. P.,et al.  Band Structure of Graphite , 2011 .

[257]  X. Cui,et al.  Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films , 2014, ACS nano.

[258]  Fan Zhang,et al.  Porous 3D graphene-based bulk materials with exceptional high surface area and excellent conductivity for supercapacitors , 2013, Scientific Reports.

[259]  G. Eda,et al.  Graphene oxide as a chemically tunable platform for optical applications. , 2010, Nature chemistry.

[260]  Yahong Xie,et al.  Chemical Vapor Deposition of Graphene , 2011 .

[261]  Longhua Tang,et al.  Self‐Assembled Graphene–Enzyme Hierarchical Nanostructures for Electrochemical Biosensing , 2010 .

[262]  Liling Hao,et al.  Graphene oxide-assisted non-immobilized SELEX of okdaic acid aptamer and the analytical application of aptasensor , 2016, Scientific Reports.

[263]  Ya‐Ping Sun,et al.  Supercritical fluid conversion of graphene oxides , 2012 .

[264]  S. M. Taghdisi,et al.  Fabrication of aptamer decorated dextran coated nano-graphene oxide for targeted drug delivery. , 2017, Carbohydrate polymers.

[265]  R. Piner,et al.  Mechanical properties of monolayer graphene oxide. , 2010, ACS nano.

[266]  Peng Chen,et al.  Centimeter-long and large-scale micropatterns of reduced graphene oxide films: fabrication and sensing applications. , 2010, ACS nano.

[267]  Vinayak Sant,et al.  Graphene-based nanomaterials for drug delivery and tissue engineering. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[268]  N. Peres,et al.  Fine Structure Constant Defines Visual Transparency of Graphene , 2008, Science.

[269]  Yu-Chen Hu,et al.  Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide. , 2012, Biomaterials.

[270]  S. Pourbeyram,et al.  Biomolecule-assisted synthesis of Ag/reduced graphene oxide nanocomposite with excellent electrocatalytic and antibacterial performance. , 2017, Materials science & engineering. C, Materials for biological applications.

[271]  B. Hong,et al.  Prospects and Challenges of Graphene in Biomedical Applications , 2013, Advanced materials.

[272]  Yang Liu,et al.  Fabrication of polymeric ionic liquid/graphene nanocomposite for glucose oxidase immobilization and direct electrochemistry. , 2011, Biosensors & bioelectronics.

[273]  Guanxiong Liu,et al.  Ultraviolet Raman microscopy of single and multilayer graphene , 2009, 0903.1922.

[274]  S. J. Owonubi,et al.  Targeted drug delivery potential of hydrogel biocomposites containing partially and thermally reduced graphene oxide and natural polymers prepared via green process , 2015, Colloid and Polymer Science.

[275]  L. C. Clark,et al.  ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY , 1962 .

[276]  Zhiqun Lin,et al.  Graphene and graphene-based nanocomposites: biomedical applications and biosafety. , 2016, Journal of materials chemistry. B.

[277]  Nurunnabi,et al.  Bioapplication of graphene oxide derivatives: drug/gene delivery, imaging, polymeric modification, toxicology, therapeutics and challenges , 2015 .

[278]  Linlin Li,et al.  Effects of graphene oxide on the development of offspring mice in lactation period. , 2015, Biomaterials.

[279]  Agnes B Kane,et al.  Biological interactions of graphene-family nanomaterials: an interdisciplinary review. , 2012, Chemical research in toxicology.

[280]  Yanli Chang,et al.  In vitro toxicity evaluation of graphene oxide on A549 cells. , 2011, Toxicology letters.

[281]  B. Hong,et al.  Biomedical applications of graphene and graphene oxide. , 2013, Accounts of chemical research.