Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors.
暂无分享,去创建一个
Shelly A Bambina | D. Kanne | M. Crittenden | M. Gough | K. Bahjat | J. Baird | B. Cottam | David J. Friedman | Thomas W Dubensky | Shelly Bambina
[1] D. Linehan,et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. , 2015, Cancer research.
[2] George E. Katibah,et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. , 2015, Cell reports.
[3] T. Pawlik,et al. The role of radiation therapy in pancreatic ductal adenocarcinoma in the neoadjuvant and adjuvant settings. , 2015, Seminars in oncology.
[4] Ying Wang,et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. , 2014, Immunity.
[5] R. Weichselbaum,et al. STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. , 2014, Immunity.
[6] G. Barber,et al. Inflammation-driven carcinogenesis is mediated through STING , 2014, Nature Communications.
[7] Ha Won Kim,et al. Activated STING in a vascular and pulmonary syndrome. , 2014, The New England journal of medicine.
[8] P. Newell,et al. TGFβ Inhibition Prior to Hypofractionated Radiation Enhances Efficacy in Preclinical Models , 2014, Cancer Immunology Research.
[9] P. Newell,et al. Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice , 2014, Radiation research.
[10] R. Schwendener,et al. DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization , 2014, PloS one.
[11] S. Gerber,et al. Radiation therapy combined with Listeria monocytogenes-based cancer vaccine synergize to enhance tumor control in the B16 melanoma model , 2014, Oncoimmunology.
[12] R. Weichselbaum,et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. , 2014, The Journal of clinical investigation.
[13] K. Schäkel,et al. Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. , 2013, Cancer cell.
[14] V. Brendel,et al. Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides , 2013, PloS one.
[15] B. Baban,et al. Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses , 2013, The Journal of Immunology.
[16] P. Newell,et al. The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the Tumor , 2013, PloS one.
[17] R. Weichselbaum,et al. Radiation-Induced Equilibrium Is a Balance between Tumor Cell Proliferation and T Cell–Mediated Killing , 2013, The Journal of Immunology.
[18] Christopher M. Jackson,et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. , 2013, International journal of radiation oncology, biology, physics.
[19] Stephen Mok,et al. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. , 2013, Cancer research.
[20] M. Crittenden,et al. The Impact of the Myeloid Response to Radiation Therapy , 2013, Clinical & developmental immunology.
[21] Sacha Gnjatic,et al. The abscopal effect associated with a systemic anti-melanoma immune response. , 2013, International journal of radiation oncology, biology, physics.
[22] R. Vance,et al. STING and the innate immune response to nucleic acids in the cytosol , 2012, Nature Immunology.
[23] S. Swetter,et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. , 2012, Translational oncology.
[24] N. Hunter,et al. CpG plus radiotherapy: a review of preclinical works leading to clinical trial , 2012, Front. Oncol..
[25] M. Gough,et al. Targeting macrophages in the tumour environment to enhance the efficacy of αOX40 therapy , 2012, Immunology.
[26] C. Ludgate. Optimizing Cancer Treatments to Induce an Acute Immune Response: Radiation Abscopal Effects, PAMPs, and DAMPs , 2012, Clinical Cancer Research.
[27] P. Newell,et al. Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy , 2012, PloS one.
[28] W. Urba,et al. Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2—Tumor and Immunological Responses , 2012, Science Translational Medicine.
[29] Jedd D. Wolchok,et al. Immunologic correlates of the abscopal effect in a patient with melanoma. , 2012, The New England journal of medicine.
[30] G. Barber,et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. , 2012, Immunity.
[31] K. Harrington,et al. Oncolytic viruses in radiation oncology. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[32] Karin Jirström,et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. , 2011, Cancer discovery.
[33] Drew A. Torigian,et al. CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans , 2011, Science.
[34] A. Weinberg,et al. Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice , 2010, Journal of immunotherapy.
[35] Roger A. Jones,et al. One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues. , 2010, Organic letters.
[36] M. Coffey,et al. Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers , 2010, Clinical Cancer Research.
[37] C. Liao,et al. Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment , 2010, Proceedings of the National Academy of Sciences.
[38] R. Weichselbaum,et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. , 2009, Blood.
[39] A. Weinberg,et al. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. , 2008, Cancer research.
[40] Laurence Zitvogel,et al. Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy , 2007, Nature Medicine.
[41] W. Shi,et al. Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment. , 2006, Anticancer research.
[42] K. Camphausen,et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy , 2006, The Journal of experimental medicine.
[43] B. Baban,et al. Cutting Edge: CpG Oligonucleotides Induce Splenic CD19+ Dendritic Cells to Acquire Potent Indoleamine 2,3-Dioxygenase-Dependent T Cell Regulatory Functions via IFN Type 1 Signaling1 , 2005, The Journal of Immunology.
[44] R. Hruban,et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. , 2005, Cancer cell.
[45] N. Kawashima,et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[46] J. Schlom,et al. Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes , 2004, Cancer Research.
[47] J. Brayer,et al. Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses , 2004, Cancer Research.
[48] L. Milas,et al. CpG Oligodeoxynucleotide Enhances Tumor Response to Radiation , 2004, Cancer Research.
[49] C. N. Coleman,et al. External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing , 2004, Cancer Research.
[50] M. Tibbs,et al. Wound healing following radiation therapy: a review. , 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[51] R. Cardiff,et al. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease , 1992, Molecular and cellular biology.
[52] Bharat B. Aggarwal,et al. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin , 1984, Nature.
[53] F. Schabel,et al. Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. , 1984, Cancer research.
[54] T. Bucknall. The effect of local infection upon wound healing: An experimental study , 1980, The British journal of surgery.
[55] J. Bertram,et al. Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture. , 1980, Cancer letters.