Efficacy of Helicobacter pylori Eradication Therapy on Platelet Recovery in Pediatric Immune Thrombocytopenic Purpura-Case Series and a Systematic Review

Evidence relating to the efficacy of Helicobacter pylori eradication therapy for chronic immune thrombocytopenic purpura (cITP) in childhood is inadequate. The aim of this retrospective study was to determine the efficacy of H. pylori eradication therapy for platelet response in pediatric patients with cITP in our hospital, and to perform a systematic review of previous reports about pediatric patients with cITP who were positive for H. pylori infection and were treated with H. pylori eradication therapy. Analysis of the data of pediatric patients with cITP in our hospital and a systematic review of digital literature databases of studies in pediatric patients with cITP were performed. Data of 33 pediatric patients with cITP from our hospital records showed that the prevalence of H. pylori infection and the rate of response to platelet therapy were 15% and 33.3%, respectively. Data of 706 pediatric patients from 18 previous reports showed that the prevalence of H. pylori infection and rate of platelet response were 23% and 43.8%, respectively. Eradication therapy for H. pylori infection in pediatric cITP patients can be expected to result in a response equivalent to that in the adult population, with fewer adverse effects than other treatments for cITP.

[1]  S. Ida,et al.  The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood , 2020, Pediatrics international : official journal of the Japan Pediatric Society.

[2]  F. Franceschi,et al.  Helicobacter pylori and extragastric diseases , 2016, Helicobacter.

[3]  M. Amiri.  Impact of Helicobacter pylori Eradication Therapy on Platelet Counts in Patients With Chronic Idiopathic Thrombocytopenic Purpura , 2015, Global journal of health science.

[4]  J. P. Braga,et al.  Helicobacter pylori infection & immune thrombocytopenic purpura in children and adolescents: A randomized controlled trial , 2015, Platelets.

[5]  Antonio Gasbarrini,et al.  Helicobacter pylori and Extragastric Diseases , 2014, Helicobacter.

[6]  A. Gasbarrini,et al.  Clinical effects of Helicobacter pylori outside the stomach , 2014, Nature Reviews Gastroenterology &Hepatology.

[7]  Y. Miyakawa,et al.  [Reference guide for management of adult idiopathic thrombocytopenic purpura (ITP) 2012 version]. , 2012, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[8]  F. Branciforte,et al.  Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: A prospective, controlled, multicenter study , 2011, Pediatric blood & cancer.

[9]  A. Stang.  Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses , 2010, European Journal of Epidemiology.

[10]  K. Fujisawa,et al.  Childhood Idiopathic Thrombocytopenic Purpura and Helicobacter pylori , 2010 .

[11]  M. Ferrara,et al.  Effect of Helicobacter pylori eradication on platelet count in children with chronic idiopathic thrombocytopenic purpura , 2009, Hematology.

[12]  A. Chuansumrit,et al.  Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: A multi‐center randomized controlled trial , 2009, Pediatric blood & cancer.

[13]  M. Karimi,et al.  Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura? , 2009, Pediatric reports.

[14]  G. Schvartzman,et al.  Demographic data, natural history, and prognostic factors of idiopathic thrombocytopenic purpura in children: A multicentered study from Argentina , 2009, Pediatric blood & cancer.

[15]  J. George,et al.  Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. , 2009, Blood.

[16]  Y. Ikeda,et al.  Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibitory FcgammaRIIB in immune thrombocytopenic purpura patients. , 2008, The Journal of clinical investigation.

[17]  M. Carli,et al.  The Role of Helicobacter pylori in Children With Chronic Idiopathic Thrombocytopenic Purpura , 2008, Journal of pediatric hematology/oncology.

[18]  H. Kidokoro,et al.  Clinical Featues and Role of Helicobacter pylori Infection in Children with Idiopathic Thrombocytopenic Purpura , 2008 .

[19]  A. Hamidieh,et al.  Helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura. , 2008, Journal of pediatric hematology/oncology.

[20]  J. Nishikawa,et al.  The long‐term efficacy of Helicobacter pylori eradication therapy in patients with idiopathic thrombocytopenic purpura , 2007, Journal of gastroenterology and hepatology.

[21]  J. Sheen,et al.  Helicobacter pylori infection and childhood idiopathic thrombocytopenic purpura. , 2007, Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi.

[22]  G. Pizzolo,et al.  Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis. , 2007, The Journal of antimicrobial chemotherapy.

[23]  R. Tamminga,et al.  H. pylori infection in childhood chronic immune thrombocytopenic purpura. , 2007, Haematologica.

[24]  T. Wang,et al.  Inflammation, atrophy, and gastric cancer. , 2007, The Journal of clinical investigation.

[25]  加藤 文代.  Helicobacter pylori infection in children with idiopathic thrombocytopenic purpura and the efficacy of eradication therapy , 2007 .

[26]  V. Poggi,et al.  The relationship between immune thrombocytopenic purpura and Helicobacter pylori infection in children: where is the truth? , 2007, European Journal of Pediatrics.

[27]  Mohsen Saleh Elalfy,et al.  Childhood ITP: 12 months follow‐up data from the prospective registry I of the Intercontinental Childhood ITP Study Group (ICIS) , 2006, Pediatric blood & cancer.

[28]  M. Asaka,et al.  Randomized study of Helicobacter pylori eradication therapy and proton pump inhibitor monotherapy for idiopathic thrombocytopenic purpura , 2005, Annals of Hematology.

[29]  N. Yoshikawa,et al.  Helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura , 2005, Pediatrics international : official journal of the Japan Pediatric Society.

[30]  H. Demir,et al.  Autoimmune thrombocytopenic purpura and Helicobacter pylori infection effectivity during childhood , 2005, American journal of hematology.

[31]  S. Amadori,et al.  Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura. , 2005, The American journal of medicine.

[32]  Y. Ikeda,et al.  Is Eradication Therapy Useful as the First Line of Treatment in Helicobacter pylori-Positive Idiopathic Thrombocytopenic Purpura? Analysis of 207 Eradicated Chronic ITP Cases in Japan , 2005, International journal of hematology.

[33]  E. El-Omar,et al.  Characteristics of Helicobacter pylori‐Induced Gastritis and the Effect of H. pylori Eradication in Patients with Chronic Idiopathic Thrombocytopenic Purpura , 2004, Helicobacter.

[34]  J. Bussel,et al.  Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura? , 2004, Blood.

[35]  Y. Oka,et al.  Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori‐associated chronic idiopathic thrombocytopenic purpura , 2004, British journal of haematology.

[36]  T. Kühne,et al.  A prospective comparative study of 2540 infants and children with newly diagnosed idiopathic thrombocytopenic purpura (ITP) from the Intercontinental Childhood ITP Study Group. , 2003, The Journal of pediatrics.

[37]  C. Chiu,et al.  Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura , 2003, Acta paediatrica.

[38]  Ó. Jónsson,et al.  Duration and morbidity of newly diagnosed idiopathic thrombocytopenic purpura in children: A prospective Nordic study of an unselected cohort. , 2003, The Journal of pediatrics.

[39]  S. Proctor,et al.  Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults: a prospective study of a population‐based cohort of 245 patients , 2003, British journal of haematology.

[40]  A. Gotoh,et al.  Can Eradication Therapy for Helicobacter pylori Really Improve the Thrombocytopenia in Idiopathic Thrombocytopenic Purpura? Our Experience and a Literature Review , 2003, International journal of hematology.

[41]  T. Klemola,et al.  Helicobacter pylori and idiopathic thrombocytopenic purpura in children. , 2003, Blood.

[42]  T. Kondo,et al.  Platelet Recovery in Patients with Idiopathic Thrombocytopenic Purpura after Eradication of Helicobacter Pylori , 2003, International journal of hematology.

[43]  Y. Niitsu,et al.  Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura , 2002, British journal of haematology.

[44]  Norikazu Yoshimura,et al.  Diagnostic accuracy of the 13C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study , 2002, American Journal of Gastroenterology.

[45]  M. Hino,et al.  Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura , 2002, Annals of Hematology.

[46]  M. Sanz,et al.  Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura , 2001, British journal of haematology.

[47]  A. Gasbarrini,et al.  Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori , 1998, The Lancet.

[48]  J. George,et al.  Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. , 1996, Blood.

[49]  A R Jadad,et al.  Assessing the quality of reports of randomized clinical trials: is blinding necessary? , 1996, Controlled clinical trials.

[50]  R. P. Madden,et al.  characteristics of , 2007 .