Direct oxidation of cycloalkanes to cycloalkanones with oxygen in water.

It doesn't take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP(+) (and a little 2-propanol to reduce it), as well as two catalytic enzymes-a hydroxylating P450 monooxygenase and an alcohol dehydrogenase. (Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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