Heme oxygenase‐1 induction mediates chemoresistance of breast cancer cells to pharmorubicin by promoting autophagy via PI3K/Akt pathway

Concerns about breast cancer had become the most dangerous cancer to women over the world, more and more anti‐cancer agents are developed to treat this malignancy. Pharmorubicin is a cytotoxic drug, widely used in the treatment of breast cancer, but its role is limited because of chemoresistance produced by cells. This study focused on exploring the influence of autophagy on the resistance of pharmorubicin in breast cancer cells.

[1]  J. Nikliński,et al.  Pituitary sex hormones enhance the pro-metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase-1 , 2019, International journal of oncology.

[2]  F. Ciardiello,et al.  Phosphatidylinositol 3-kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer cells , 2017, Oncotarget.

[3]  Jian Jin,et al.  TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway , 2017, Scientific Reports.

[4]  Baohong Jiang,et al.  Inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[5]  Yuxiu Shi,et al.  Effects of endoplasmic reticulum stress on the autophagy, apoptosis, and chemotherapy resistance of human breast cancer cells by regulating the PI3K/AKT/mTOR signaling pathway , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[6]  J. Nikliński,et al.  Pituitary sex hormones enhance the pro-metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase-1 , 2016, International journal of oncology.

[7]  J. Ko,et al.  PI3K/Akt/mTOR activation by suppression of ELK3 mediates chemosensitivity of MDA-MB-231 cells to doxorubicin by inhibiting autophagy. , 2016, Biochemical and biophysical research communications.

[8]  P. Stattin,et al.  Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth , 2016, PloS one.

[9]  Xi Gu,et al.  Circulating microRNA-451 as a predictor of resistance to neoadjuvant chemotherapy in breast cancer. , 2016, Cancer biomarkers : section A of Disease markers.

[10]  L. Ning,et al.  Inhibition of autophagy induced by PTEN loss promotes intrinsic breast cancer resistance to trastuzumab therapy , 2016, Tumor Biology.

[11]  Aiping Luo,et al.  MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy , 2015, Molecular Cancer.

[12]  Yuanfang Ma,et al.  Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy , 2015, Cancer science.

[13]  S. Farajnia,et al.  Natural inhibitors of PI3K/AKT signaling in breast cancer: emphasis on newly-discovered molecular mechanisms of action. , 2015, Pharmacological research.

[14]  Chien-Huang Lin,et al.  Epidermal Growth Factor Stimulates Nuclear Factor-κB Activation and Heme Oxygenase-1 Expression via c-Src, NADPH Oxidase, PI3K, and Akt in Human Colon Cancer Cells , 2014, PloS one.

[15]  A. Thorburn,et al.  Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent , 2014, Autophagy.

[16]  T. Al-Tweigeri,et al.  Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway , 2014, British Journal of Cancer.

[17]  Jun Zhang,et al.  Exosomes mediate drug resistance transfer in MCF-7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein , 2014, Tumor Biology.

[18]  Jianping Chen,et al.  MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin , 2014, Oncotarget.

[19]  H. Chen,et al.  Formononetin Inhibits Migration and Invasion of MDA-MB-231 and 4T1 Breast Cancer Cells by Suppressing MMP-2 and MMP-9 Through PI3K/AKT Signaling Pathways , 2014, Hormone and Metabolic Research.

[20]  Lixin Wei,et al.  Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells , 2013, Cell & Bioscience.

[21]  Y. Lee,et al.  Role of HO-1 in the Arsenite-Induced Neurotoxicity in Primary Cultured Cortical Neurons , 2013, Molecular Neurobiology.

[22]  S. Singhal,et al.  Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells , 2013, Autophagy.

[23]  Yuan Liu,et al.  Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1 , 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

[24]  R. Christopherson,et al.  The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. , 2012, Journal of proteomics.