Administração tópica de cloridrato de hidralazina na viabilidade de retalho cutâneo randômico em ratos

PURPOSE: Assess the effect of hydralazine hydrochloride, for iontophoresis, on the viability of random skin flaps in rats. METHODS: Sixty Wistar rats was randonly destributed in 4 groups (n=15), these animals was submited as randon dorsal skin flaps as cranial base with measure 10X4 cm. The animals from group 1 was utilized as control, in group 2 was submitted to direct current o 4mA-20' immediately after the surgery and on the two subsequent days. In group 3 the stimulation eletric simulation with hydralazine hydrochloride. In group 4 iontophorese with hydralazine hydrochloride 4mA-20'. The analysis of the results was made on the seventh day post operative and interpreted with test non parametric of Kruskal-Wallis. RESULTS: and the necrotic area stayed fixed in: group 1= 45%; group 2= 39%; group 3= 46% and group 4= 41%, being the statistical analysis did not evedenced any significant. CONCLUSION: The hydralazine hydrochloride when taken for iontophorese was not efficacious in reduce the necrotic area.

[1]  R. Liebano,et al.  Experimental model for transcutaneous electrical nerve stimulation on ischemic random skin flap in rats , 2003 .

[2]  R. Liebano,et al.  The effect of transcutaneous electrical nerve stimulation on the viability of random skin flaps in rats , 2002 .

[3]  P. Reeh,et al.  Interactions of inflammatory mediators stimulating release of calcitonin gene-related peptide, substance P and prostaglandin E2 from isolated rat skin , 2001, Neuropharmacology.

[4]  T. Lundeberg,et al.  Effects of calcitonin gene-related peptide on tissue survival, blood flow and neutrophil recruitment in experimental skin flaps. , 1999, British journal of plastic surgery.

[5]  J. Cui,et al.  Spinal cord stimulation improves survival in ischemic skin flaps: an experimental study of the possible mediation by calcitonin gene-related peptide. , 1999, Plastic and reconstructive surgery.

[6]  T. Waris,et al.  Adequate blood flow is essential for reinnervation in neurovascular skin flaps. , 1999, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[7]  L. Ferreira,et al.  Effect of dimethyl sulphoxide on necrosis of skin flaps in rats , 1998 .

[8]  G. Evans,et al.  Calcitonin gene-related peptide improves skin flap survival and tissue inflammation , 1998, Neuropeptides.

[9]  K. Fukuta,et al.  Topical Administration of Prostaglandin E1 with Iontophoresis for Skin Flap Viability , 1997, Annals of Plastic Surgery.

[10]  C. Nieto,et al.  A comparative study on the effect of various pharmacological agents on the survival of skin flaps in the rat , 1992 .

[11]  P. Hedén,et al.  Calcitonin gene-related peptide (CGRP) and transcutaneous electrical nerve stimulation (TENS) increase cutaneous blood flow in a musculocutaneous flap in the rat. , 1988, Acta physiologica Scandinavica.

[12]  T. Kaufman,et al.  The Salutary Effects of the Bed on the Survival of Experimental Flaps , 1985, Annals of plastic surgery.

[13]  C. Kerrigan.  Skin Flap Failure: Pathophysiology , 1983, Plastic and reconstructive surgery.

[14]  C. Pang,et al.  Hemodynamics and Viability of Acute Neurovascular Island Skin Flaps in Rats , 1980, Plastic and reconstructive surgery.

[15]  J. Ogura,et al.  Vasodilating Agents in Augmentation of Skin Flap Survival , 1979, Otolaryngology and head and neck surgery.

[16]  F. Finseth,et al.  PREVENTION OF SKIN FLAP NECROSIS BY A COURSE OF TREATMENT WITH VASODILATOR DRUGS , 1978, Plastic and reconstructive surgery.

[17]  O. Ugland,et al.  Flaps and flap necrosis. Improving the circulation in skin flaps with Complamin and with Dicoumarol: animal experiments. , 1966, Acta chirurgica Scandinavica.

[18]  R. A. Henry,et al.  THE DESIGN OF A PEDICLE FLAP IN THE RAT TO STUDY NECROSIS AND ITS PREVENTION , 1965, Plastic and reconstructive surgery.