Role of Cysteine Cathepsins in Matrix Degradation and Cell Signalling

Cysteine cathepsins participate in extracellular matrix (ECM) degradation and remodelling and thus influence important cellular processes such as cell transformation and differentiation, motility, adhesion, invasion, angiogenesis, and metastasis. Also, cathepsins are involved in cell signalling and are capable of activating specific cell receptors and growth factors or liberating them from the ECM. In this review we emphasize recent studies on cathepsins in regard to ECM degradation and cell signalling.

[1]  J. Kos,et al.  Cysteine protease cathepsin X modulates immune response via activation of β2 integrins , 2008, Immunology.

[2]  S. Zahler,et al.  RGD-dependent Binding of Procathepsin X to Integrin αvβ3 Mediates Cell-adhesive Properties* , 2006, Journal of Biological Chemistry.

[3]  Bonnie F. Sloane,et al.  Cysteine cathepsins: multifunctional enzymes in cancer , 2006, Nature Reviews Cancer.

[4]  J. Kos,et al.  Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells. , 2006, Experimental cell research.

[5]  J. Kos,et al.  Intracellular proteolytic activity of cathepsin B is associated with capillary‐like tube formation by endothelial cells in vitro , 2006, Journal of cellular biochemistry.

[6]  T. Murohara,et al.  Localization of Cysteine Protease, Cathepsin S, to the Surface of Vascular Smooth Muscle Cells by Association with Integrin ανβ3 , 2006 .

[7]  R. Pérez-Montfort,et al.  Immunosuppressive activity of proteases in cervical carcinoma. , 2005, Gynecologic oncology.

[8]  J. Kos,et al.  Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. , 2005, Experimental cell research.

[9]  E. Im,et al.  Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. , 2005, Molecular biology of the cell.

[10]  E. Chavakis,et al.  Cathepsin L is required for endothelial progenitor cell–induced neovascularization , 2005, Nature Medicine.

[11]  Erik Sahai,et al.  Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis , 2003, Nature Cell Biology.

[12]  J. Kos,et al.  Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. , 2003, Experimental cell research.

[13]  MS Pepper,et al.  Extracellular Proteolysis and Angiogenesis , 2001, Thrombosis and Haemostasis.

[14]  U. Felbor,et al.  Generation and degradation of human endostatin proteins by various proteinases , 2000, FEBS letters.

[15]  L. Miles,et al.  Discriminating between Cell Surface and Intracellular Plasminogen-binding Proteins: Heterogeneity in Profibrinolytic Plasminogen-binding Proteins on Monocytoid Cells , 2000, Thrombosis and Haemostasis.

[16]  E. Nemoto,et al.  Proteolysis of Human Monocyte CD14 by Cysteine Proteinases (Gingipains) from Porphyromonas gingivalis Leading to Lipopolysaccharide Hyporesponsiveness1 , 2000, The Journal of Immunology.

[17]  R. Kalluri,et al.  Canstatin, a Novel Matrix-derived Inhibitor of Angiogenesis and Tumor Growth* , 2000, The Journal of Biological Chemistry.

[18]  V. Vetvicka,et al.  Anti‐human procathepsin D activation peptide antibodies inhibit breast cancer development , 1999, Breast Cancer Research and Treatment.

[19]  A. Baici,et al.  Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases , 1999, FEBS letters.

[20]  A. Hollander,et al.  Molecular Interaction and Matrix Assembly , 1998, The Biochemical journal.

[21]  H. Rochefort,et al.  Characterization of very acidic phagosomes in breast cancer cells and their association with invasion. , 1994, Journal of cell science.

[22]  S. Zahler,et al.  RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties. , 2006, The Journal of biological chemistry.

[23]  L. Creemers,et al.  Intracellular versus extracellular digestion of collagen , 1996 .