Budd-Chiari Syndrome Treated with Acylated Streptokinase-Plasminogen Complex

and osteoclasts (Johnston et al. 1968), and it has been suggested that some cases may be primarily due to overprod-uction of bone rather than to decreased resorption (Manzke et al. 1982). The generalized increase in bone scan activity with absent renal uptake in our patient further confirms that osteopetrosis is sometimes related to increased bone turnover. This case therefore demonstrates the presence of Paget's disease as a hitherto unknown complication of benign osteopetrosis in a young adult, and shows features suggesting that, in some cases at least, osteopetrosis is caused by increased turnover of bone. The association with Crohn's disease in two family members implies that this disease may also be linked with osteopetrosis.