Drug Delivery to the Cochlea Using PLGA Nanoparticles

Objectives: This study aimed to investigate the efficacy of encapsulating therapeutic molecules in poly lactic/glycolic acid (PLGA) nanoparticles for drug delivery to the cochlea.

[1]  Alan Van Heuvelen,et al.  Intermediate physics for medicine and biology , 1989 .

[2]  Yoshiaki,et al.  Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method. , 1999, International journal of pharmaceutics.

[3]  E. Hultcrantz,et al.  The microsphere method for studies of inner ear blood flow. , 1988, ORL; journal for oto-rhino-laryngology and its related specialties.

[4]  T. Ishihara,et al.  Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[5]  R. Kimura,et al.  Volumetric and Dimensional Analysis of the Guinea Pig Inner Ear , 2001, The Annals of otology, rhinology, and laryngology.

[6]  M V Goycoolea,et al.  Clinical Aspects of Round Window Membrane Permeability Under Normal and Pathological Conditions , 2001, Acta oto-laryngologica.

[7]  S. Juhn,et al.  Blood-labyrinth barrier and fluid dynamics of the inner ear. , 2001, The international tinnitus journal.

[8]  A. Salt,et al.  Quantification of solute entry into cochlear perilymph through the round window membrane , 2001, Hearing Research.

[9]  Y. Mizushima,et al.  Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsion. , 1982, Annals of the rheumatic diseases.

[10]  L. Minor,et al.  Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy. , 1999, The American journal of otology.

[11]  K. Kawamoto,et al.  Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[12]  H. Staecker,et al.  Steroid Perfusion of the Inner Ear for Sudden Sensorineural Hearing Loss after Failure of Conventional Therapy: A Pilot Study , 2002, Acta oto-laryngologica.

[13]  T. Ishihara,et al.  Treatment of experimental arthritis with poly(d, l-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate , 2005, Annals of the rheumatic diseases.

[14]  Kenji Ohyama,et al.  Volume flow rate of perilymph in the guinea-pig cochlea , 1988, Hearing Research.