Intraspinal analgesia: an historical overview

The application of opioids in the proximity of the spinal cord is a recent addition to the forms of treatment available for pain relief. During the last 20 years we have learned more about the intimate mechanisms of the action of opiates then we had in the preceding 5 millennia. Opium, in fact, has been used for medical purposes from prehistoric times. On the basis of the newly acquired knowledge, we are now applying opioids in more effective ways and providing more patients with long overdue relief of their pain.

[1]  R. McCarthy,et al.  Epidural Ketamine for Control of Postoperative Pain: Two Comments , 1986 .

[2]  W. Boyle,et al.  Selective remembering: anesthesia and memory. , 1986, Anesthesia and analgesia.

[3]  S. K. Henderson,et al.  Nalbuphine augmentation of analgesia and reversal of side effects following epidural hydromorphone. , 1986, Anesthesiology.

[4]  J. DesMarteau,et al.  Acute pulmonary edema resulting from nalbuphine reversal of fentanyl-induced respiratory depression. , 1986, Anesthesiology.

[5]  R. Nesbakken.  Nomenclature on Energy. Practical Consequences of the Relevant SI‐shunt , 1985, Acta anaesthesiologica Scandinavica. Supplementum.

[6]  J. Islas,et al.  Epidural Ketamine for Control of Postoperative Pain , 1985, Anesthesia and analgesia.

[7]  M. Mesaros,et al.  REVERSAL OF PRURITIS, SECONDARY TO EPIDURAL MORPHINE, WITH THE NARCOTIC AGONIST/ANTAGONIST NALBUPHINE (NUBAIN(R)) , 1985 .

[8]  Josef K. Wang.  Intrathecal morphine for intractable pain secondary to cancer of pelvic organs , 1985, Pain.

[9]  H. Breivik,et al.  Epidural Morphine for Postoperative Pain: Experience with 1085 Patients , 1985, Acta anaesthesiologica Scandinavica.

[10]  S. Arnér,et al.  Differential Effects of Epidural Morphine in the Treatment of Cancer‐related Pain , 1985, Acta anaesthesiologica Scandinavica.

[11]  B. Hare,et al.  Opiate and clonidine receptors on spinal sympathetic neurons inhibit adenylate cyclase to produce neuronal depression , 1984, Pain.

[12]  S. Savage,et al.  Intrathecal clonidine control of cancer pain when spinal morphine tolerance develops , 1984, PAIN.

[13]  J. Hammond.  REVERSAL OF OPIOID-ASSOCIATED LATE-ONSET RESPIRATORY DEPRESSION BY NALBUPHINE HYDROCHLORIDE , 1984, The Lancet.

[14]  L. Gustafsson,et al.  Kinetics of Morphine in Cerebrospinal Fluid After Epidural Administration , 1984, Acta anaesthesiologica Scandinavica.

[15]  Cousins Mj,et al.  Intrathecal and epidural administration of opioids , 1984 .

[16]  J. Kinney,et al.  SPLANCHNIC OXYGEN CONSUMPTION AND SUBSTRATE RALANCE FOLLOWING ACCIDENTAL INJURY , 1984 .

[17]  R. Dudziak,et al.  Reversal by Naluphine of Respiratory Depression Caused by Fentanyl , 1984, Anesthesia and analgesia.

[18]  T. Gordh,et al.  EPIDURAL CLONIDINE PRODUCES ANALGESIA , 1984, The Lancet.

[19]  G. Nordberg.  Pharmacokinetic aspects of spinal morphine analgesia , 1984, Acta anaesthesiologica Scandinavica. Supplementum.

[20]  D. Prough,et al.  Acute pulmonary edema in healthy teenagers following conservative doses of intravenous naloxone. , 1984, Anesthesiology.

[21]  J. Bion,et al.  Intrathecal ketamine for war surgery. A preliminary study under field conditions , 1983, Anaesthesia.

[22]  J. Bonica,et al.  Management of cancer pain. , 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[23]  R. Taff.  Pulmonary edema following naloxone administration in a patient without heart disease. , 1983, Anesthesiology.

[24]  E. Hazrati.  Continuous low‐dose intrathecal morphine administration in the treatment of chronic pain of malignant origin , 1983 .

[25]  D. Murphy,et al.  Epidural buprenorphine for pain relief after major abdominal surgery , 1983, Anaesthesia.

[26]  T. Hedner,et al.  Pharmacokinetic Aspects of Epidural Morphine Analgesia , 1983, Anesthesiology.

[27]  O. Ravlo,et al.  Pain treatment on outpatient basis utilizing extradural opiates. A danish multicentre study comprising 105 patients , 1983, Pain.

[28]  M. Mphahlele,et al.  Postpartum shock due to inferior vena cava rupture. , 1983, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[29]  A. Matsuki.  Nothing new under the sun--a Japanese pioneer in the clinical use of intrathecal morphine. , 1983, Anesthesiology.

[30]  T. Yaksh,et al.  The analgetic effects of an intrathecally administered partial opiate agonist, nalbuphine hydrochloride. , 1982, European journal of pharmacology.

[31]  D. A. Pybus,et al.  Dose-effect relationships of extradural morphine. , 1982, British journal of anaesthesia.

[32]  L. Gustafsson,et al.  Extradural and parenteral morphine: kinetics and effects in postoperative pain. A controlled clinical study. , 1982, British journal of anaesthesia.

[33]  T. Abboud,et al.  HYPERBARIC INTRATHECAL MORPHINE FOR THE RELIEF OF LABOR PAIN , 1982 .

[34]  T. Oyama,et al.  Epidural β-endorphin in treatment of pain , 1982, Canadian Anaesthetists' Society journal.

[35]  R. Blomberg,et al.  Long‐Term Epidural Morphine Analgesia , 1982, Acta anaesthesiologica Scandinavica. Supplementum.

[36]  E. Vincenti,et al.  Epidural narcotics and control of arterial pressure in a pre-eclamptic patient. , 1982, Canadian Anaesthetists' Society journal.

[37]  G. Blaise,et al.  Epidural Morphine for Postoperative Pain Relief: A Dose‐response Curve , 1982, Anesthesiology.

[38]  P. Deligné,et al.  MATERNAL AND FETAL CONCENTRATION OF MORPHINE AFTER INTRATHECAL ADMINISTRATION DURING LABOUR , 1982 .

[39]  L. Gustafsson,et al.  DISPOSITION OF MORPHINE IN CEREBROSPINAL FLUID AFTER EPIDURAL ADMINISTRATION , 1982, The Lancet.

[40]  J. Brock‐Utne,et al.  Epidural ketamine. A preliminary report. , 1982, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[41]  J. Brock‐Utne,et al.  Intrathecal ketamine with preservative - histological effects on spinal nerve roots of baboons. , 1982, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[42]  E. Lanz,et al.  Epidural Morphine for Postoperative Analgesia: A Double‐Blind Study , 1982 .

[43]  T. Yaksh.  Spinal opiate analgesia: Characteristics and principles of action , 1981, PAIN®.

[44]  L. Mather,et al.  Peridural meperidine in humans: analgesic response, pharmacokinetics, and transmission into CSF. , 1981, Anesthesiology.

[45]  N. Rawal,et al.  Postoperative Pain Relief by Epidural Morphine , 1981, Anesthesia and analgesia.

[46]  B. Duffy.  Experiences with epidural morphine in obstetrics , 1981, Anaesthesia.

[47]  T. Yaksh,et al.  Continuous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin. , 1981, Mayo Clinic proceedings.

[48]  H. T. Davenport,et al.  COMPARISON OF EPIDURAL AND INTRAMUSCULAR PETHIDINE FOR ANALGESIA IN LABOUR , 1981, British journal of obstetrics and gynaecology.

[49]  T. Yaksh,et al.  Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen. , 1981, Anesthesiology.

[50]  J. W. Chapin,et al.  Respiratory arrest after intrathecal morphine. , 1981, JAMA.

[51]  S. Reiz,et al.  Epidural Morphine for Postoperative Pain Relief , 1981, Acta anaesthesiologica Scandinavica.

[52]  J. S. Crawford.  Experiences with epidular morphine in obstetrics , 1981 .

[53]  A. Baraka,et al.  Intrathecal Injection of Morphine for Obstetric Analgesia , 1981, Anesthesiology.

[54]  J. Hilfrich,et al.  LONG-TERM PERIDURAL MORPHINE ANALGESIA IN CANCER PAIN , 1981, The Lancet.

[55]  P. Solinas,et al.  Iatrathecd morphine for the control of the pain of myocardial infarction , 1981, Anaesthesia.

[56]  L. Milne,et al.  Epidural morphine in terminal care , 1981, Anaesthesia.

[57]  P. Cartwright,et al.  Intrathecal morphine as sole analgesic during labour. , 1980, British medical journal.

[58]  V. Christensen.  Respiratory depression after extradural morphine. , 1980, British journal of anaesthesia.

[59]  S. Reiz,et al.  SIDE-EFFECTS OF EPIDURAL MORPHINE , 1980, The Lancet.

[60]  P. Bromage,et al.  Epidural Narcotics for Postoperative Analgesia , 1980, Anesthesia and analgesia.

[61]  P. Booker,et al.  Obstetric pain relief using epidural morphine , 1980, Anaesthesia.

[62]  R. Katzenelson,et al.  OBSERVATIONS ON EXTRADURAL MORPHINE ANALGESIA IN VARIOUS PAIN CONDITIONS , 1980 .

[63]  T. L. James,et al.  CNS depression from intrathecal morphine. , 1980, Anesthesiology.

[64]  G. Davies,et al.  Analgesic action of extradural fentanyl. , 1980, British journal of anaesthesia.

[65]  J. R. Johnston,et al.  Epidural morphine , 1980, Anaesthesia.

[66]  N. Ling,et al.  PROFOUND ANALGESIC EFFECTS OF β-ENDORPHIN IN MAN , 1980, The Lancet.

[67]  L. Mather,et al.  SPINAL NARCOTICS AND RESPIRATORY DEPRESSION , 1979, The Lancet.

[68]  L. Mather,et al.  SELECTIVE SPINAL ANALGESIA , 1979, The Lancet.

[69]  F. Magora,et al.  EPIDURAL MORPHINE IN TREATMENT OF PAIN , 1979, The Lancet.

[70]  John E. Thomas,et al.  Pain relief by intrathecally applied morphine in man. , 1979, Anesthesiology.

[71]  W. El.  Review and overview of four decades of opiate research. , 1979, Advances in biochemical psychopharmacology.

[72]  G. Fischbach,et al.  Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[73]  A. Dray,et al.  PHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL STUDIES OF MORPHINE AND ENKEPHALIN ON RAT SUPRASPINAL NEURONES AND CAT SPINAL NEURONES , 1978, British journal of pharmacology.

[74]  J. Wang.  Antinociceptive Effect of Intrathecally Administered Serotonin , 1977, Anesthesiology.

[75]  L. Iversen,et al.  Opiate analgesics inhibit substance P release from rat trigeminal nucleus , 1977, Nature.

[76]  S. Snyder,et al.  Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section , 1976, Brain Research.

[77]  T. Yaksh,et al.  Analgesia mediated by a direct spinal action of narcotics. , 1976, Science.

[78]  J. Thompson,et al.  The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. , 1976, The Journal of pharmacology and experimental therapeutics.

[79]  J. Henry,et al.  Effects of morphine and naloxone on dorsal horn neurones in the cat. , 1974, Canadian journal of physiology and pharmacology.

[80]  L. Terenius.  Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex. , 2009, Acta pharmacologica et toxicologica.

[81]  S. Snyder,et al.  Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain , 1973, Nature.

[82]  S. Snyder,et al.  Opiate Receptor: Demonstration in Nervous Tissue , 1973, Science.

[83]  J. Besson,et al.  Effets de la morphine sur les activités des interneurones de la couche V de Rexed de la corne dorsale chez le chat spinal. , 1972 .

[84]  A. Goldstein,et al.  Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[85]  W. Martin.  Opioid antagonists. , 1967, Pharmacological reviews.

[86]  P. Cook.  Experiences in the first year of an "open door" x-ray department. , 1966, British medical journal.

[87]  P. Portoghese.  A new concept on the mode of interaction of narcotic analgesics with receptors. , 1965, Journal of medicinal chemistry.

[88]  W. Mushin.  Triumph over pain. , 1955, British journal of anaesthesia.

[89]  Kramer Sn.  First pharmacopeia in man's recorded history. , 1954 .

[90]  S. N. Kramer.  First pharmacopeia in man's recorded history. , 1954, American journal of pharmacy and the sciences supporting public health.