Physiology and role of irisin in glucose homeostasis

[1]  Min-Seon Kim,et al.  Effects of alpha-lipoic Acid on body weight in obese subjects. , 2011, The American journal of medicine.

[2]  Yuan Zhang,et al.  Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway , 2015, PloS one.

[3]  Mary T. Brinkoetter,et al.  Circulating irisin in relation to insulin resistance and the metabolic syndrome. , 2013, The Journal of clinical endocrinology and metabolism.

[4]  Susan M. Tarlo,et al.  In Vivo and In Vitro Studies , 2017 .

[5]  D. Melton,et al.  Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation , 2017, Cell.

[6]  N. Al-Daghri,et al.  The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes. , 2014, American journal of physiology. Endocrinology and metabolism.

[7]  H. Pareja-Galeano,et al.  Inconsistency in Circulating Irisin Levels: What is Really Happening? , 2014, Hormone and Metabolic Research.

[8]  Suhuan Liu,et al.  Association of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults , 2014, PloS one.

[9]  S. Koh,et al.  High Serum Irisin Level as an Independent Predictor of Diabetes Mellitus , 2016, Medicine.

[10]  C. Mantzoros,et al.  The effect of Irisin on antioxidant system in liver. , 2014, Free radical biology & medicine.

[11]  Maria F. Vasiloglou,et al.  Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition. , 2014, The Journal of clinical endocrinology and metabolism.

[12]  M. Ruth A PGC1–α–dependent myokine that drives brown–fat–like development of white fat and thermogenesis , 2012 .

[13]  C. Mantzoros,et al.  Irisin in response to acute and chronic whole-body vibration exercise in humans. , 2014, Metabolism: clinical and experimental.

[14]  Jonathan C. Cohen,et al.  ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion , 2014, Cell.

[15]  Y. Hwang,et al.  The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype , 2016, Cardiovascular Diabetology.

[16]  C. Sturgeon,et al.  Standardization of FSH, LH and hCG—Current position and future prospects , 2007, Molecular and Cellular Endocrinology.

[17]  D. Gašperíková,et al.  Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies , 2014, The Journal of physiology.

[18]  J. Martínez,et al.  Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients. , 2014, Metabolism: clinical and experimental.

[19]  E. Roth,et al.  Expansion , 2021, The Last Abolition.

[20]  C. Mantzoros,et al.  An update on the validity of irisin assays and the link between irisin and hepatic metabolism. , 2015, Metabolism: clinical and experimental.

[21]  P. Vokonas,et al.  Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events , 2014, International Journal of Obesity.

[22]  M. Fasshauer,et al.  Serum levels of the myokine irisin in relation to metabolic and renal function. , 2014, European journal of endocrinology.

[23]  F. Casanueva,et al.  FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine , 2013, PloS one.

[24]  C. Mantzoros,et al.  Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans , 2016, International Journal of Obesity.

[25]  A. Stengel,et al.  Irisin: what promise does it hold? , 2013, Current opinion in clinical nutrition and metabolic care.

[26]  C. Gutiérrez‐Repiso,et al.  FNDC5 could be regulated by leptin in adipose tissue , 2014, European journal of clinical investigation.

[27]  Haichang Wang,et al.  Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses. , 2015, Journal of molecular and cellular cardiology.

[28]  Yuan Zhang,et al.  Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling , 2014, Diabetes.

[29]  Irisin is more strongly predicted by muscle oxidative potential than adiposity in non-diabetic men , 2015, Journal of Physiology and Biochemistry.

[30]  Qian Zhao,et al.  PGC-1 mediates the regulation of metformin in muscle irisin expression and function. , 2015, American journal of translational research.

[31]  F. Huang,et al.  Metformin promotes irisin release from murine skeletal muscle independently of AMP‐activated protein kinase activation , 2015, Acta physiologica.

[32]  J. Gerich,et al.  Physiology of glucose homeostasis , 2000, Diabetes, obesity & metabolism.

[33]  In-kyu Lee,et al.  Serum irisin levels in new-onset type 2 diabetes. , 2013, Diabetes research and clinical practice.

[34]  Zheng Chen,et al.  Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. , 2013, Journal of hepatology.

[35]  M. Bidlingmaier,et al.  Measurement of human growth hormone by immunoassays: current status, unsolved problems and clinical consequences. , 2010, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[36]  A. Derbent,et al.  Irisin as an early marker for predicting gestational diabetes mellitus: a prospective study , 2016, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[37]  J. Moreno-Navarrete,et al.  Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects , 2015, PloS one.

[38]  Hai-Jian Sun,et al.  FNDC5 overexpression and irisin ameliorate glucose/lipid metabolic derangements and enhance lipolysis in obesity. , 2015, Biochimica et biophysica acta.

[39]  D. Sommers,et al.  A longitudinal analysis , 1992 .

[40]  Jian-jun Liu,et al.  Lower circulating irisin is associated with type 2 diabetes mellitus. , 2013, Journal of diabetes and its complications.

[41]  S. Tangye,et al.  Inflammatory Mechanisms in Obesity , 2013 .

[42]  M. Moreno-Aliaga,et al.  Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid , 2015, Journal of Physiology and Biochemistry.

[43]  Y. Pan,et al.  Study on the Distribution and Elimination of the New Hormone Irisin In Vivo: New Discoveries Regarding Irisin , 2015, Hormone and Metabolic Research.

[44]  向光大 Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice , 2015 .

[45]  J. Ukropec,et al.  Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes , 2014, Peptides.

[46]  B. Klapp,et al.  Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index , 2013, Peptides.

[47]  Xinghua Pan,et al.  Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice , 2016, Journal of cardiovascular pharmacology.

[48]  A. Lucia,et al.  Serum irisin levels, precocious myocardial infarction, and healthy exceptional longevity. , 2014, The American journal of medicine.

[49]  I. Castan-Laurell,et al.  Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine , 2014, International Journal of Obesity.

[50]  A. Hoeflich,et al.  Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise , 2014, International journal of biological sciences.

[51]  J. Manson,et al.  Prospective Study of , 2007 .

[52]  C. Drevon,et al.  Irisin – a myth rather than an exercise-inducible myokine , 2015, Scientific Reports.

[53]  Eun Soo Kim,et al.  Association between Serum Irisin Levels and Non-Alcoholic Fatty Liver Disease in Health Screen Examinees , 2014, PloS one.

[54]  A. Stengel,et al.  Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update , 2014, Peptides.

[55]  M. Kozak Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems , 1989, Molecular and cellular biology.

[56]  Fuqiang Liu,et al.  Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients , 2015, Journal of diabetes research.

[57]  S. Kuang,et al.  Myostatin knockout drives browning of white adipose tissue through activating the AMPK‐PGC1α‐Fndc5 pathway in muscle , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[58]  M. Pardo,et al.  Irisin: ‘fat’ or artefact , 2015, Clinical endocrinology.

[59]  D. Friebe,et al.  Serum irisin levels are regulated by acute strenuous exercise. , 2015, The Journal of clinical endocrinology and metabolism.

[60]  U. Wisløff,et al.  Evidence against a Beneficial Effect of Irisin in Humans , 2013, PloS one.

[61]  G. Schuler,et al.  Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure—relevance of inflammatory cytokines , 2015, Journal of cachexia, sarcopenia and muscle.

[62]  Weizhen Zhang,et al.  Irisin Inhibits Hepatic Cholesterol Synthesis via AMPK-SREBP2 Signaling , 2016, EBioMedicine.

[63]  J. Steinacker,et al.  Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis. , 2016, Metabolism: clinical and experimental.

[64]  H. Erickson,et al.  The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer , 2013, The Journal of Biological Chemistry.

[65]  C. Mermier,et al.  Characterization of the metabolic effects of irisin on skeletal muscle in vitro , 2014, Diabetes, obesity & metabolism.

[66]  S. Kim,et al.  Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK. , 2015, Molecular endocrinology.

[67]  Xiaofeng Ma,et al.  Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice. , 2016, International journal of biological macromolecules.

[68]  J. Martínez,et al.  Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women , 2014, American journal of human biology : the official journal of the Human Biology Council.

[69]  Soo-Hyun Park,et al.  New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. , 2015, Cellular signalling.

[70]  C. Mandarim-de-Lacerda,et al.  Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice , 2015, Molecular and Cellular Endocrinology.

[71]  J. Kushner,et al.  Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice , 2015, Diabetologia.

[72]  Xiaodong Sun,et al.  Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway. , 2015, American journal of physiology. Heart and circulatory physiology.

[73]  S. Ellefsen,et al.  Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training , 2015, PloS one.

[74]  Yuan Zhang,et al.  Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis , 2014, PloS one.

[75]  Xiu-wei Zhang,et al.  Relationship between serum irisin levels and urinary albumin excretion in patients with type 2 diabetes. , 2015, Journal of diabetes and its complications.

[76]  J. Krakoff,et al.  Increased 24-hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans , 2015, Appetite.

[77]  G. Sesti,et al.  High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects , 2014, Acta Diabetologica.

[78]  F. Sanchis-Gomar,et al.  The p38–PGC-1α–irisin–betatrophin axis , 2014, Adipocyte.

[79]  Gangyi Yang,et al.  Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome. , 2015, The Journal of clinical endocrinology and metabolism.

[80]  Jian-jun Liu,et al.  Relationship between circulating irisin, renal function and body composition in type 2 diabetes. , 2014, Journal of diabetes and its complications.

[81]  Ting Gao,et al.  Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function , 2014, Diabetology & Metabolic Syndrome.

[82]  L. Bu,et al.  Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity. , 2015, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[83]  Yibing Huang,et al.  Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes , 2016, PloS one.

[84]  C. Mantzoros,et al.  Irisin in humans: recent advances and questions for future research. , 2014, Metabolism: clinical and experimental.

[85]  S. Rane,et al.  SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise. , 2015, The Journal of Biological Chemistry.

[86]  Hai-Jian Sun,et al.  Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. , 2015, Clinical science.

[87]  Chao-Yung Wang,et al.  Decrease in Irisin in Patients with Chronic Kidney Disease , 2013, PloS one.

[88]  Suhuan Liu,et al.  Association of serum irisin and body composition with chronic kidney disease in obese Chinese adults: a cross-sectional study , 2015, BMC Nephrology.

[89]  G. Lippi,et al.  Circulating irisin detection: Does it really work? , 2015, Trends in Endocrinology & Metabolism.

[90]  M. Mulholland,et al.  Central and Peripheral Irisin Differentially Regulate Blood Pressure , 2015, Cardiovascular Drugs and Therapy.

[91]  M. Mulholland,et al.  Irisin: A myokine with locomotor activity , 2015, Neuroscience Letters.

[92]  P. Sun,et al.  Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. , 2011, Cell metabolism.

[93]  G. Boaventura,et al.  Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients , 2013, Hormone and Metabolic Research.

[94]  M. Zou,et al.  Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism. , 2016, Molecular endocrinology.

[95]  R. G. Gaines Das,et al.  The first international standard for human leptin and the first international standard for mouse leptin: comparison of candidate preparations by in vitro bioassays and immunoassays. , 2001, Journal of molecular endocrinology.

[96]  J. Eckel,et al.  Browning of white fat: does irisin play a role in humans? , 2014, The Journal of endocrinology.

[97]  C. Mantzoros,et al.  Effects of a 1‐year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children , 2014, Obesity.

[98]  R. Gaines-Das,et al.  The international standard for platelet-derived growth factor-BB: comparison of candidate preparations by in vitro bioassays and immunoassays. , 1998, Growth factors.

[99]  C. Mermier,et al.  Irisin, a unique non-inflammatory myokine in stimulating skeletal muscle metabolism , 2015, Journal of Physiology and Biochemistry.

[100]  M. Nasr-Esfahani,et al.  Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells , 2013, Neuroscience.

[101]  S. Romero-Hidalgo,et al.  Irisin levels before and after physical activity among school‐age children with different BMI: A direct relation with leptin , 2015, Obesity.

[102]  J. Orava,et al.  Different metabolic responses of human brown adipose tissue to activation by cold and insulin. , 2011, Cell metabolism.

[103]  C. Drevon,et al.  The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans , 2014, The FEBS journal.

[104]  T. Raastad,et al.  Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women , 2014, European Journal of Applied Physiology.

[105]  J. Moreno-Navarrete,et al.  Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. , 2013, The Journal of clinical endocrinology and metabolism.

[106]  Mary T. Brinkoetter,et al.  FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. , 2012, Metabolism: clinical and experimental.

[107]  Junfeng Zhang,et al.  Lower irisin level in patients with type 2 diabetes mellitus: A case‐control study and meta‐analysis , 2016, Journal of diabetes.

[108]  C. Mantzoros,et al.  Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. , 2014, The Journal of clinical endocrinology and metabolism.

[109]  K. Hirata,et al.  Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease , 2015, Respirology.

[110]  P. Puigserver,et al.  Regulation of adipogenesis and energy balance by PPARγ and PGC-1 , 2000, International Journal of Obesity.

[111]  F. Schmidt Meta-Analysis , 2008 .

[112]  C. Mantzoros,et al.  Irisin: A true, circulating hormone. , 2015, Metabolism: clinical and experimental.

[113]  Jiandie D. Lin,et al.  Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. , 2013, Cell metabolism.

[114]  B. Spiegelman,et al.  Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. , 2015, Cell metabolism.

[115]  N. Çolakoğlu,et al.  A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues , 2014, Peptides.

[116]  Henriette Pilegaard,et al.  Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle , 2003, The Journal of physiology.

[117]  Rui Wang,et al.  Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy , 2016, Annals of clinical biochemistry.

[118]  K. Häkkinen,et al.  Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? , 2013, The Journal of physiology.

[119]  S. L. Dun,et al.  Irisin-immunoreactivity in neural and non-neural cells of the rodent , 2013, Neuroscience.

[120]  M. Nasr-Esfahani,et al.  Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues. , 2015, Gene.

[121]  G. Frühbeck,et al.  Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice , 2014, International Journal of Obesity.

[122]  Yuan Zhang,et al.  Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. , 2016, American journal of physiology. Endocrinology and metabolism.

[123]  L. Xiong,et al.  Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway , 2016, International Journal of Obesity.

[124]  C. Mantzoros,et al.  Irisin in response to exercise in humans with and without metabolic syndrome. , 2015, The Journal of clinical endocrinology and metabolism.

[125]  Robert Walgate,et al.  Proliferation , 1985, Nature.

[126]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[127]  F. Rizk,et al.  Irisin levels in relation to metabolic and liver functions in Egyptian patients with metabolic syndrome. , 2016, Canadian journal of physiology and pharmacology.

[128]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[129]  K. Kaestner,et al.  Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting , 2014, Diabetes.

[130]  Qian Zhao,et al.  Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice. , 2015, International journal of clinical and experimental pathology.

[131]  T. Reinehr,et al.  Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis. , 2015, The Journal of clinical endocrinology and metabolism.

[132]  A. Goldfine,et al.  Inflammation and insulin resistance. , 2006, The Journal of clinical investigation.

[133]  L. Rochette,et al.  Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. , 2015, Canadian journal of physiology and pharmacology.

[134]  C. Mantzoros,et al.  Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines. , 2013, Metabolism: clinical and experimental.

[135]  G. Chrousos,et al.  Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2 , 2015, European journal of clinical investigation.

[136]  P. Puigserver,et al.  A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.

[137]  K. Goto,et al.  Resistance exercise induces a greater irisin response than endurance exercise. , 2015, Metabolism: clinical and experimental.

[138]  Z. Li,et al.  Circulating irisin is lower in gestational diabetes mellitus. , 2015, Endocrine journal.

[139]  J. Peterson,et al.  Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5 , 2014, PeerJ.

[140]  C. Mantzoros,et al.  Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans , 2014, International Journal of Obesity.

[141]  C. Mantzoros,et al.  Association between circulating irisin and homocysteine in patients with nonalcoholic fatty liver disease , 2015, Endocrine.

[142]  J. Hobson,et al.  What is the State-of-the-Art on Lucid Dreaming? - Recent Advances and Questions for Future Research , 2014 .

[143]  Pedagógia,et al.  Cross Sectional Study , 2019 .

[144]  C. Mantzoros,et al.  Irisin in patients with nonalcoholic fatty liver disease. , 2014, Metabolism: clinical and experimental.

[145]  Rachel M. Perron,et al.  Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. , 2014, Cell metabolism.

[146]  W. Mitch,et al.  Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues , 2015, International Journal of Obesity.