Serotonergic modulation of response inhibition and re‐engagement? Results of a study in healthy human volunteers

Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior (response inhibition) and initiate a new one (response re‐engagement) is important in the activities of daily life. Central serotonin (5‐HT) function is thought to be a critical component of these cognitive functions. In recent studies, 5‐HT failed to affect stop‐signal reaction time (SSRT), a fundamental process in behavioral inhibition. We were interested if response inhibition and re‐engagement are influenced through central 5‐HT activity as mediated via the 5‐HT transporter.

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