Mood and Behavioural Changes with Progestational Agents

Steroid hormones may produce a wide variety of psychiatric syndromes (1), (2), and the progestational steroids are no exception. We were alerted to this by the occurrence of an acute schizophrenic psychosis following the withdrawal of 30 mg. Enovid (Enavid) daily, which was being used to control endometriosis (3). The patient's psychotic symptoms showed remission with drug replacement and relapse on placebo.