Olivo-cerebellar cluster-based universal control system

The olivo-cerebellar network plays a key role in the organization of vertebrate motor control. The oscillatory properties of inferior olive (IO) neurons have been shown to provide timing signals for motor coordination in which spatio-temporal coherent oscillatory neuronal clusters control movement dynamics. Based on the neuronal connectivity and electrophysiology of the olivo-cerebellar network we have developed a general-purpose control approach, which we refer to as a universal control system (UCS), capable of dealing with a large number of actuator parameters in real time. In this UCS, the imposed goal and the resultant feedback from the actuators specify system properties. The goal is realized through implementing an architecture that can regulate a large number of parameters simultaneously by providing stimuli-modulated spatio-temporal cluster dynamics.

[1]  R. Llinás,et al.  Patterns of Spontaneous Purkinje Cell Complex Spike Activity in the Awake Rat , 1999, The Journal of Neuroscience.

[2]  R. Llinás,et al.  Dynamic organization of motor control within the olivocerebellar system , 1995, Nature.

[3]  J J Hopfield,et al.  Neural networks and physical systems with emergent collective computational abilities. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Llinás,et al.  Electrotonic coupling between neurons in cat inferior olive. , 1974, Journal of neurophysiology.

[5]  D. Long I of the Vortex: From Neurons to Self , 2002 .

[6]  R. Llinás,et al.  Uniform olivocerebellar conduction time underlies Purkinje cell complex spike synchronicity in the rat cerebellum. , 1993, The Journal of physiology.

[7]  D. Humphrey,et al.  Motor control : concepts and issues , 1991 .

[8]  I. Lampl,et al.  Subthreshold oscillations of the membrane potential: a functional synchronizing and timing device. , 1993, Journal of neurophysiology.

[9]  R. Llinás,et al.  The Functional Organization of the Olivo‐Cerebellar System as Examined by Multiple Purkinje Cell Recordings , 1989, The European journal of neuroscience.

[10]  Vladimir I. Nekorkin,et al.  Modeling inferior olive neuron dynamics , 2002, Neural Networks.

[11]  Enrico Mugnaini,et al.  Comparative study of glutamate decarboxylase immunoreactive boutons in the mammalian inferior olive , 1989, The Journal of comparative neurology.

[12]  R. Llinás,et al.  GABAergic modulation of complex spike activity by the cerebellar nucleoolivary pathway in rat. , 1996, Journal of neurophysiology.

[13]  R. Llinás,et al.  Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage‐dependent ionic conductances. , 1981, The Journal of physiology.

[14]  R Llinás,et al.  Some organizing principles for the control of movement based on olivocerebellar physiology. , 1997, Progress in brain research.

[15]  R. Llinás,et al.  Structural study of inferior olivary nucleus of the cat: morphological correlates of electrotonic coupling. , 1974, Journal of neurophysiology.

[16]  R. Llinás,et al.  Oscillatory properties of guinea‐pig inferior olivary neurones and their pharmacological modulation: an in vitro study. , 1986, The Journal of physiology.

[17]  Elena Leznik,et al.  Electrotonically Mediated Oscillatory Patterns in Neuronal Ensembles: An In Vitro Voltage-Dependent Dye-Imaging Study in the Inferior Olive , 2002, The Journal of Neuroscience.

[18]  J. Simpson,et al.  Microcircuitry and function of the inferior olive , 1998, Trends in Neurosciences.

[19]  C. Sotelo,et al.  Localization of glutamic‐acid‐decarboxylase‐immunoreactive axon terminals in the inferior olive of the rat, with special emphasis on anatomical relations between GABAergic synapses and dendrodendritic gap junctions , 1986, The Journal of comparative neurology.

[20]  J. Voogd,et al.  Cerebellar Influence on Olivary Excitability in the Cat , 1995, The European journal of neuroscience.

[21]  D. McCormick,et al.  Synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current I(h). , 1997, Journal of neurophysiology.