MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model.

[1]  H. M. Nielsen,et al.  Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression , 2012, Pharmaceutical Research.

[2]  H. M. Nielsen,et al.  Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[3]  J. Biton,et al.  Interplay between TNF and Regulatory T Cells in a TNF-Driven Murine Model of Arthritis , 2011, The Journal of Immunology.

[4]  A. Radjenovic,et al.  MRI for the assessment and monitoring of RA—what can it tell us? , 2011, Nature Reviews Rheumatology.

[5]  Nicola Dalbeth,et al.  Measuring bone erosion and edema in rheumatoid arthritis: A comparison of manual segmentation and RAMRIS methods , 2011, Journal of magnetic resonance imaging : JMRI.

[6]  J. Mountz,et al.  Emerging MRI methods in rheumatoid arthritis , 2011, Nature Reviews Rheumatology.

[7]  B. Lévy,et al.  Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma. , 2010, The American journal of pathology.

[8]  Frederick Wolfe,et al.  Rheumatoid arthritis , 2010, The Lancet.

[9]  P. Tak,et al.  Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis. , 2010, Arthritis and rheumatism.

[10]  Smadar Cohen,et al.  Silencing of proinflammatory genes targeted to peritoneal-residing macrophages using siRNA encapsulated in biodegradable microspheres. , 2010, Biomaterials.

[11]  H. M. Nielsen,et al.  Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation , 2009, Journal of Controlled Release.

[12]  E. Doelker,et al.  Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[13]  R. Vollenhoven,et al.  Treatment of rheumatoid arthritis: state of the art 2009 , 2009, Nature Reviews Rheumatology.

[14]  Robert Langer,et al.  Knocking down barriers: advances in siRNA delivery , 2009, Nature Reviews Drug Discovery.

[15]  D. Chang,et al.  IL-1β in Irrigation Fluid and MRNA Expression in Synovial Tissue of the Knee Joint as Therapeutic Markers of Inflammation in Collagen Antibody-Induced Arthritis , 2009, Disease markers.

[16]  S. Jacobsen,et al.  Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders. , 2008, Journal of pharmaceutical sciences.

[17]  J. Cornish,et al.  Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease , 2008, Annals of the rheumatic diseases.

[18]  Justine R. Smith,et al.  Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 , 2008, Nature.

[19]  Tejraj M Aminabhavi,et al.  Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[20]  G. Burmester,et al.  Cells of the synovium in rheumatoid arthritis. Macrophages , 2007, Arthritis research & therapy.

[21]  F. McQueen A vital clue to deciphering bone pathology: MRI bone oedema in rheumatoid arthritis and osteoarthritis , 2007, Annals of the Rheumatic Diseases.

[22]  Franz Kainberger,et al.  Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis. , 2007, Arthritis and rheumatism.

[23]  John J Rossi,et al.  Rational design and in vitro and in vivo delivery of Dicer substrate siRNA , 2006, Nature Protocols.

[24]  Marcin Szkudlarek,et al.  Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints , 2006, Arthritis research & therapy.

[25]  D. Scherman,et al.  Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis. , 2006, Arthritis and rheumatism.

[26]  Matthias John,et al.  RNAi-mediated gene silencing in non-human primates , 2006, Nature.

[27]  M. Mayerhoefer,et al.  STIR vs. T1‐weighted fat‐suppressed gadolinium‐enhanced MRI of bone marrow edema of the knee: Computer‐assisted quantitative comparison and influence of injected contrast media volume and acquisition parameters , 2005, Journal of magnetic resonance imaging : JMRI.

[28]  E. Massarotti,et al.  Rheumatoid Arthritis: An Overview of New and Emerging Therapies , 2005, Journal of clinical pharmacology.

[29]  R. Schiffelers,et al.  Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. , 2005, Arthritis and rheumatism.

[30]  Matthias John,et al.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs , 2004, Nature.

[31]  I. Rioja,et al.  Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment , 2004, Clinical and experimental immunology.

[32]  M. Amarzguioui Improved siRNA-mediated silencing in refractory adherent cell lines by detachment and transfection in suspension. , 2004, BioTechniques.

[33]  Neal Stewart,et al.  Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis. , 2003, Arthritis and rheumatism.

[34]  Paul Bird,et al.  OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system. , 2003, The Journal of rheumatology.

[35]  U. Mödder,et al.  Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints: sensitive detection of morphologic changes in rheumatoid arthritis. , 2001, Arthritis and rheumatism.

[36]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[37]  G. Burmester,et al.  Macrophages in rheumatoid arthritis , 2000, Arthritis research.

[38]  M Ostergaard,et al.  Quantification of synovistis by MRI: correlation between dynamic and static gadolinium-enhanced magnetic resonance imaging and microscopic and macroscopic signs of synovial inflammation. , 1998, Magnetic resonance imaging.

[39]  Hanne Mørck Nielsen,et al.  High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[40]  E. Schwarz,et al.  The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis. , 2010, Advances in experimental medicine and biology.

[41]  N. Parameswaran,et al.  Tumor necrosis factor-α signaling in macrophages. , 2010, Critical reviews in eukaryotic gene expression.

[42]  R. V. van Vollenhoven,et al.  Treatment of rheumatoid arthritis: state of the art 2009. , 2009, Nature reviews. Rheumatology.

[43]  J. Kjems,et al.  Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[44]  J. Kjems,et al.  Chitosan/siRNA Nanoparticle-mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[45]  L. Khachigian Collagen antibody-induced arthritis , 2006, Nature Protocols.