The aim of the study was to analyze the effect of surgical intervention on the status of the ovarian follicular apparatus in patients with benign ovarian cystic tumors (BCOTs) based on the results of morphometric studies.Material and methods. The authors have studied surgical material of 60 patients aged 18-47 years with BCOTs: serous cystadenoma (20 cases), serous papillary cystadenoma (7 cases), mucinous cystadenoma (12 cases), mature teratoma (23 cases). Microscopic slides of ovarian tissue stained with hematoxylin and eosin were obtained and morphological structure of BCOTs, presence of the intact ovarian tissue surrounding neoplasm and the density of follicles there were studied based on their qualitative characteristics (maturity, signs of degeneration).Results. It was found out that development of fibrosis in the wall of BCOTs significantly depends on the tumor histogenesis: the greatest thickness of fibrosis was detected in serous papillary cystadenomas, the smallest in the group of mature teratomas, the average values were determined in mucinous and serous cystadenomas of the ovaries. The influence of BCOTs on the ovarian reserve does not depend on its morphological structure, localization and diameter. The intact ovarian tissue is removed along with BCOTs during adnexectomy, ovarian resection and in 48.8% of cases – during cystectomy. During cystectomy, probability of the perifocal intact ovarian tissue presence is reduced due to the growth of fibrous tissue in this area. However, the negative impact of BCOTs on the ovarian reserve occurs not only due to surgical removal of the ovarian tissue, but also as a result of inhibition of folliculogenesis at the preoperative stage.Conclusion. BCOTs of the presented morphological groups negatively affect the follicular apparatus due to both – inhibition of folliculogenesis at the preoperative stage and loss of ovarian tissue during surgery. More pronounced perifocal proliferation of fibrous tissue was noted with serous papillary cystadenomas.
[1]
Richard A. White,et al.
Investigating the effect of lifestyle risk factors upon number of aspirated and mature oocytes in in vitro fertilization cycles: Interaction with antral follicle count
,
2019,
PloS one.
[2]
H. Roman.
Endometriosis surgery and preservation of fertility, what surgeons should know.
,
2018,
Journal of visceral surgery.
[3]
T. Umehara,et al.
The stromal fibrosis in aging ovary
,
2018,
Aging.
[4]
D. Stefanidis,et al.
SAGES guidelines for the use of laparoscopy during pregnancy
,
2017,
Surgical Endoscopy.
[5]
Xin Tao,et al.
Weigh the pros and cons to ovarian reserve before stripping ovarian endometriomas prior to IVF/ICSI: A meta-analysis
,
2017,
PloS one.
[6]
M. Polak,et al.
Long‐term outcome of ovarian function in women with intermittent premature ovarian insufficiency
,
2017,
Clinical endocrinology.
[7]
R. Caltabiano,et al.
MR imaging of ovarian masses: classification and differential diagnosis
,
2015,
Insights into Imaging.
[8]
Z. M. Ikromova,et al.
SOMATIC AND GYNECOLOGICAL STATUS OF REPRODUCTIVE-AGE OF WOMEN WITH BENIGN TUMORS AND TUMOR-LIKE FORMATIONS OF THE OVARIES
,
2017
.
[9]
P. Arunalatha,et al.
Ovarian tumours- Incidence and distribution in a tertiary referral center in south India
,
2014
.
[10]
T. N. Unguryanu,et al.
Brief recommendations on description, analysis and presentation of data in scientific papers.
,
2011
.