Tattoo‐Paper Transfer as a Versatile Platform for All‐Printed Organic Edible Electronics

The use of natural or bioinspired materials to develop edible electronic devices is a potentially disruptive technology that can boost point-of-care testing. The technology exploits devices that can be safely ingested, along with pills or even food, and operated from within the gastrointestinal tract. Ingestible electronics can potentially target a significant number of biomedical applications, both as therapeutic and diagnostic tool, and this technology may also impact the food industry, by providing ingestible or food-compatible electronic tags that can "smart" track goods and monitor their quality along the distribution chain. Temporary tattoo-paper is hereby proposed as a simple and versatile platform for the integration of electronics onto food and pharmaceutical capsules. In particular, the fabrication of all-printed organic field-effect transistors on untreated commercial tattoo-paper, and their subsequent transfer and operation on edible substrates with a complex nonplanar geometry is demonstrated.

[1]  Barbara Stadlober,et al.  Cellulose as biodegradable high-k dielectric layer in organic complementary inverters , 2013 .

[2]  Niyazi Serdar Sariciftci,et al.  Chapter 8 - Biocompatible Integration of Electronics Into Food Sensors , 2016 .

[3]  S. Bauer,et al.  Biocompatible and Biodegradable Materials for Organic Field‐Effect Transistors , 2010 .

[4]  Christopher J Bettinger,et al.  Materials Advances for Next-Generation Ingestible Electronic Medical Devices. , 2015, Trends in biotechnology.

[5]  Michael C. McAlpine,et al.  Silk‐Based Conformal, Adhesive, Edible Food Sensors , 2012, Advanced materials.

[6]  Zhenan Bao,et al.  High-performance plastic transistors fabricated by printing techniques , 1997 .

[7]  Vijaya Raghavan,et al.  Advancements in Drying Techniques for Food, Fiber, and Fuel , 2012 .

[8]  R. Langer,et al.  Physiologic Status Monitoring via the Gastrointestinal Tract , 2015, PloS one.

[9]  H. Sirringhaus,et al.  High-Resolution Ink-Jet Printing of All-Polymer Transistor Circuits , 2000, Science.

[10]  D. Gerlier,et al.  Use of MTT colorimetric assay to measure cell activation. , 1986, Journal of immunological methods.

[11]  Robert Langer,et al.  Microneedles for drug delivery via the gastrointestinal tract. , 2015, Journal of pharmaceutical sciences.

[12]  Christian Cipriani,et al.  Tattoo Conductive Polymer Nanosheets for Skin‐Contact Applications , 2015, Advanced healthcare materials.

[13]  Natalie Stingelin,et al.  Semiconducting:insulating polymer blends for optoelectronic applications—a review of recent advances , 2014 .

[14]  R. Sarpeshkar,et al.  Large-scale complementary integrated circuits based on organic transistors , 2000, Nature.

[15]  Young Jo Kim,et al.  Biologically derived melanin electrodes in aqueous sodium-ion energy storage devices , 2013, Proceedings of the National Academy of Sciences.

[16]  Joon Hak Oh,et al.  Effect of the alkyl spacer length on the electrical performance of diketopyrrolopyrrole-thiophene vinylene thiophene polymer semiconductors , 2015 .

[17]  Francesco Stellacci,et al.  Edible sensors for meat and seafood freshness , 2018 .

[18]  A. Chandrakasan,et al.  Prolonged energy harvesting for ingestible devices , 2016, Nature Biomedical Engineering.

[19]  G. Iddan,et al.  Wireless capsule endoscopy , 2003, Gut.

[20]  Henning Sirringhaus,et al.  Spectroscopic investigation of oxygen- and water-induced electron trapping and charge transport instabilities in n-type polymer semiconductors. , 2012, Journal of the American Chemical Society.

[21]  Alexandra G Martinez,et al.  Electrochemical sensing based on printable temporary transfer tattoos. , 2012, Chemical communications.

[22]  Wenwen Xu,et al.  Food‐Materials‐Based Edible Supercapacitors , 2016 .

[23]  Young Jo Kim,et al.  Self-deployable current sources fabricated from edible materials. , 2013, Journal of materials chemistry. B.

[24]  Guglielmo Lanzani,et al.  Photothermal cellular stimulation in functional bio-polymer interfaces , 2015, Scientific Reports.

[25]  A. Lansdown,et al.  A Pharmacological and Toxicological Profile of Silver as an Antimicrobial Agent in Medical Devices , 2010, Advances in pharmacological sciences.

[26]  Xian Huang,et al.  Materials, Designs, and Operational Characteristics for Fully Biodegradable Primary Batteries , 2014, Advanced materials.

[27]  Zhihua Chen,et al.  Macroscopic and high-throughput printing of aligned nanostructured polymer semiconductors for MHz large-area electronics , 2015, Nature Communications.

[28]  Robert Langer,et al.  Oral delivery of biologics using drug‐device combinations , 2017, Current opinion in pharmacology.

[29]  Alberto Salleo,et al.  Moderate doping leads to high performance of semiconductor/insulator polymer blend transistors , 2013, Nature Communications.

[30]  H. Bouwmeester,et al.  Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. , 2012, ACS nano.

[31]  George G Malliaras,et al.  Organic bioelectronics: a new era for organic electronics. , 2013, Biochimica et biophysica acta.

[32]  George G. Malliaras,et al.  The Rise of Organic Bioelectronics , 2014 .

[33]  George M. Savage,et al.  An Ingestible Sensor for Measuring Medication Adherence , 2015, IEEE Transactions on Biomedical Engineering.

[34]  Janos Veres,et al.  Gate Insulators in Organic Field-Effect Transistors , 2004 .

[35]  Rodolfo Cruz-Silva,et al.  Influence of P3HT concentration on morphological, optical and electrical properties of P3HT/PS and P3HT/PMMA binary blends , 2011 .

[36]  Hagen Klauk,et al.  Organic electronics : materials, manufacturing and applications , 2006 .

[37]  J. F. Dijksman,et al.  A novel ingestible electronic drug delivery and monitoring device. , 2013, Gastrointestinal endoscopy.

[38]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.