The Role for ink4a in Melanoma Pathogenesis
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[1] F. Kaye,et al. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB. , 1994, Oncogene.
[2] Nobuyuki Shishido,et al. Mice Lacking p27 Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors , 1996, Cell.
[3] A. Balmain,et al. Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 HA‐ras gene regulated by a mouse tyrosinase promoter , 1995, Molecular carcinogenesis.
[4] K. Isobe,et al. Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. , 1991, The EMBO journal.
[5] R. Weinberg,et al. Effects of an Rb mutation in the mouse , 1992, Nature.
[6] A. Kopf,et al. Lifetime risk for development of skin cancer in the U.S. population: current estimate is now 1 in 5. , 1996, Journal of the American Academy of Dermatology.
[7] L. J. Veer,et al. N-ras mutations in human cutaneous melanoma from sun-exposed body sites , 1989, Molecular and cellular biology.
[8] P. Heinzel,et al. Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers , 1996, International journal of cancer.
[9] S. Jhanwar,et al. Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype. , 1992, Oncogene.
[10] K. Kinzler,et al. Deletion of p16 and p15 genes in brain tumors. , 1994, Cancer research.
[11] S. Suster,et al. Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes. , 1991, The American journal of pathology.
[12] S. Tavtigian,et al. Complex structure and regulation of the P16 (MTS1) locus. , 1995, Cancer research.
[13] H. Sasano,et al. In situ hybridization and immunohistochemistry of p53 tumor suppressor gene in human esophageal carcinoma. , 1992, The American journal of pathology.
[14] W. Gerald,et al. Analysis of p21WAF1/CIP1 in primary bladder tumors. , 1998, Oncology research.
[15] P. O'Connor,et al. A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma. , 1995, Cancer research.
[16] E. Newcomb,et al. Alterations of multiple tumor suppressor genes (p53 (17p13), p16INK4 (9p21), and DBM (13q14)) in B‐CELL chronic lymphocytic leukemia , 1995, Molecular carcinogenesis.
[17] G. Hannon,et al. Deletion of the p16 and p15 genes in human bladder tumors. , 1995, Journal of the National Cancer Institute.
[18] K. Manova-Todorova,et al. Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 Kip1 , 1996, Cell.
[19] M. Skolnick,et al. Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus , 1994, Nature Genetics.
[20] G. Hannon,et al. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 , 1993, Nature.
[21] C. Cordon-Cardo,et al. Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors. , 1994, Cancer research.
[22] A. Monaghan,et al. A cell‐specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number‐related expression in transgenic mice. , 1994, The EMBO journal.
[23] L. Chin,et al. Role of the INK4a Locus in Tumor Suppression and Cell Mortality , 1996, Cell.
[24] L. Sandkuijl,et al. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds , 1995, Nature Genetics.
[25] C. Cordon-Cardo. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. , 1995, The American journal of pathology.
[26] T. Hunter,et al. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age , 1994, Cell.
[27] M. Schartl,et al. The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma. , 1992, The EMBO journal.
[28] A. Kamb,et al. Cell-cycle regulators and cancer. , 1995, Trends in genetics : TIG.
[29] D. Carson,et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers , 1994, Nature.
[30] F. Zindy,et al. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest , 1995, Cell.
[31] R. Wilson,et al. Induction of tumorigenicity and lack of in vitro growth requirement for 12-O-tetradecanoylphorbol-13-acetate by transfection of murine melanocytes with v-Ha-ras. , 1989, Cancer research.
[32] G. Hannon,et al. Cloning and characterization of murine p16INK4a and p15INK4b genes. , 1995, Oncogene.
[33] H. Koeffler,et al. p27/Kip1 mutation found in breast cancer. , 1996, Cancer research.
[34] W. Gerald,et al. Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors. , 1996, Cancer research.
[35] Stephen J. Elledge,et al. Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control , 1995, Cell.
[36] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.
[37] A. Gown,et al. p53 and mdm-2 expression in malignant melanoma: an immunocytochemical study of expression of p53, mdm-2, and markers of cell proliferation in primary versus metastatic tumors. , 1995, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[38] J. Herman,et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers , 1995, Nature Medicine.
[39] G. Hannon,et al. Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes , 1995 .
[40] R. Sharp,et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[41] Van Dyke Ta,et al. Analysis of viral-host protein interactions and tumorigenesis in transgenic mice. , 1994 .
[42] H. Höfler,et al. Ras gene mutations: a rare event in nonmetastatic primary malignant melanoma. , 1995, The Journal of investigative dermatology.
[43] H. Dosaka-akita,et al. Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity. , 1996, Cancer research.
[44] D. Grignon,et al. Somatic mutations of the WAF1/CIP1 gene in primary prostate cancer. , 1995, Oncogene.
[45] N. Hayward,et al. Mutations and defective expression of the WAF1 p21 tumour‐suppressor gene in malignant melanomas , 1995, Melanoma research.
[46] K. Isselbacher,et al. Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[47] W. Clark,et al. Germline p16 mutations in familial melanoma , 1994, Nature Genetics.
[48] James M. Roberts,et al. A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 Kip1 -Deficient Mice , 1996, Cell.
[49] M. Skolnick,et al. A cell cycle regulator potentially involved in genesis of many tumor types. , 1994, Science.
[50] S. Ogawa,et al. Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies. , 1996, Blood.
[51] S. Lowe,et al. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.
[52] M. Bulyk,et al. Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. , 1996, Cancer research.
[53] Gregory J. Hannon,et al. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest , 1994, Nature.
[54] F. Real,et al. Differentiation antigens of melanocytes and melanoma: analysis of melanosome and cell surface markers of human pigmented cells with monoclonal antibodies. , 1988, The Journal of investigative dermatology.
[55] S. Elledge,et al. A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. , 1996, Trends in cell biology.
[56] C. Cordon-Cardo,et al. Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype. , 1989, Oncogene.
[57] M. Hollstein,et al. Clinical implications of the p53 tumor-suppressor gene. , 1993, The New England journal of medicine.
[58] H. Koeffler,et al. Role of the cyclin-dependent kinase inhibitors in the development of cancer. , 1995, Blood.
[59] C. Poremba,et al. Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression. , 1995, Oncology research.
[60] J. Hoeffler,et al. Ras mutations in human melanoma: a marker of malignant progression. , 1994, The Journal of investigative dermatology.
[61] B. Vogelstein,et al. p53 mutations in human cancers. , 1991, Science.