Bioengineering horizon scan 2020

Horizon scanning is intended to identify the opportunities and threats associated with technological, regulatory and social change. In 2017 some of the present authors conducted a horizon scan for bioengineering (Wintle et al., 2017). Here we report the results of a new horizon scan that is based on inputs from a larger and more international group of 38 participants. The final list of 20 issues includes topics spanning from the political (the regulation of genomic data, increased philanthropic funding and malicious uses of neurochemicals) to the environmental (crops for changing climates and agricultural gene drives). The early identification of such issues is relevant to researchers, policy-makers and the wider public.

[1]  Mark A. Burgman,et al.  Classical meets modern in the IDEA protocol for structured expert judgement , 2018 .

[2]  M. Scheffer,et al.  Trajectories of the Earth System in the Anthropocene , 2018, Proceedings of the National Academy of Sciences.

[3]  Donald R. Ort,et al.  Synthetic glycolate metabolism pathways stimulate crop growth and productivity in the field , 2019, Science.

[4]  M. Dando,et al.  Dual-Use Nano-Neurotechnology: , 2018, Politics & Life Sciences.

[5]  J. Peccoud,et al.  The Open Insulin Project: A Case Study for 'Biohacked' Medicines. , 2018, Trends in biotechnology.

[6]  Pasquale Stano,et al.  Gene-Expressing Liposomes as Synthetic Cells for Molecular Communication Studies , 2019, Front. Bioeng. Biotechnol..

[7]  N. H. Ravindranath,et al.  The top 100 questions of importance to the future of global agriculture , 2010 .

[8]  Kevin K. Yang,et al.  Machine-learning-guided directed evolution for protein engineering , 2018, Nature Methods.

[9]  William J Sutherland,et al.  The need for environmental horizon scanning. , 2009, Trends in ecology & evolution.

[10]  Martine J. Barons,et al.  Assessment of the response of pollinator abundance to environmental pressures using structured expert elicitation , 2018, Journal of Apicultural Research.

[11]  Anna Wexler The Social Context of “Do-It-Yourself” Brain Stimulation: Neurohackers, Biohackers, and Lifehackers , 2017, Front. Hum. Neurosci..

[12]  Victoria Hemming,et al.  Eliciting improved quantitative judgements using the IDEA protocol: A case study in natural resource management , 2018, PloS one.

[13]  T. Lenton,et al.  Climate tipping points — too risky to bet against , 2019, Nature.

[14]  Megan J. Palmer,et al.  Anomaly handling and the politics of gene drives , 2018 .

[15]  Megan J. Palmer,et al.  A more systematic approach to biological risk , 2015, Science.

[16]  Marc-Olivier Déplaude,et al.  La philanthropie comme investissement: Contribution à l’étude des stratégies de reproduction et de légitimation des élites économiques , 2018 .

[17]  M. Burgman,et al.  The Value of Performance Weights and Discussion in Aggregated Expert Judgments , 2018, Risk analysis : an official publication of the Society for Risk Analysis.

[18]  M. Milone,et al.  An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer , 2019, American journal of hematology.

[19]  C. Löfstedt,et al.  A plant factory for moth pheromone production , 2014, Nature Communications.

[20]  S. Shinde,et al.  Biohacking , 2017, Anaesthesia.

[21]  Atul K. Jain,et al.  Global Carbon Budget 2019 , 2019, Earth System Science Data.

[22]  M. Pezzotti,et al.  Edible plants for oral delivery of biopharmaceuticals. , 2017, British journal of clinical pharmacology.

[23]  David Cyranoski,et al.  The CRISPR-baby scandal: what’s next for human gene-editing , 2019, Nature.

[24]  Andrew M. Liebhold,et al.  Invasion Science: A Horizon Scan of Emerging Challenges and Opportunities. , 2017, Trends in ecology & evolution.

[25]  J. Napier,et al.  The first crop plant genetically engineered to release an insect pheromone for defence , 2015, Scientific Reports.

[26]  T. Erb,et al.  A synthetic pathway for the fixation of carbon dioxide in vitro , 2016, Science.

[27]  G. Fond,et al.  Innovative mechanisms of action for pharmaceutical cognitive enhancement: A systematic review , 2015, Psychiatry Research.

[28]  T. Erb Back to the future: Why we need enzymology to build a synthetic metabolism of the future , 2019, Beilstein journal of organic chemistry.

[29]  Pratyoosh Shukla,et al.  Engineering PGPMOs through Gene Editing and Systems Biology: A Solution for Phytoremediation? , 2018, Trends in biotechnology.

[30]  C. Kemner,et al.  Spatial Frequency Training Modulates Neural Face Processing: Learning Transfers from Low- to High-Level Visual Features , 2017, Front. Hum. Neurosci..

[31]  O. Dhankher,et al.  Climate resilient crops for improving global food security and safety. , 2018, Plant, cell & environment.

[32]  Dan Murray,et al.  Advancing the State of Policy Delphi Practice: A Systematic Review Evaluating Methodological Evolution, Innovation, and Opportunities , 2016 .

[33]  R. Cohen Kadosh,et al.  The regulation of cognitive enhancement devices: refining Maslen et al.'s model , 2015, Journal of law and the biosciences.

[34]  R. Zilinskas,et al.  Fake botox, real threat. , 2010, Scientific American.

[35]  M. Dando,et al.  Dual-Use Nano-Neurotechnology: An assessment of the implications of trends in science and technology. , 2018, Politics and the life sciences : the journal of the Association for Politics and the Life Sciences.

[36]  Ethan Bier,et al.  Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi , 2015, Proceedings of the National Academy of Sciences.

[37]  Paul Neve,et al.  Gene drive systems: do they have a place in agricultural weed management? , 2018, Pest management science.

[38]  Maywa Montenegro de Wit Gene driving the farm: who decides, who owns, and who benefits? , 2019, Agroecology and Sustainable Food Systems.

[39]  G. Ackerman,et al.  Assessing the bioweapons threat , 2015, Science.

[40]  Ebony B. Madden,et al.  Model framework for governance of genomic research and biobanking in Africa – a content description , 2018, AAS open research.

[41]  G. Lomonossoff,et al.  Stability of plant virus-based nanocarriers in gastrointestinal fluids† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7nr07182e , 2017, Nanoscale.

[42]  J. Collins Gene drives in our future: challenges of and opportunities for using a self-sustaining technology in pest and vector management , 2018, BMC Proceedings.

[43]  David H Guston,et al.  Understanding ‘anticipatory governance’ , 2014, Social studies of science.

[44]  Xiao Yang,et al.  Bioinspired neuron-like electronics , 2019, Nature Materials.

[45]  M. Hodges,et al.  Schistosomiasis in School Age Children in Sierra Leone After 6 Years of Mass Drug Administration With Praziquantel , 2019, Front. Public Health.

[46]  E. Fasani,et al.  The potential of genetic engineering of plants for the remediation of soils contaminated with heavy metals. , 2018, Plant, cell & environment.

[47]  Mohammed AlQuraishi End-to-end differentiable learning of protein structure , 2018, bioRxiv.

[48]  E. Honkavaara,et al.  Pre-crop Values From Satellite Images for Various Previous and Subsequent Crop Combinations , 2019, Front. Plant Sci..

[49]  Nikolaus Sonnenschein,et al.  Improving Reproducibility in Synthetic Biology , 2019, Front. Bioeng. Biotechnol..

[50]  Rick Parente,et al.  A case study of long-term Delphi accuracy , 2011 .

[51]  Nicholas E. Matthews,et al.  Aligning sustainability assessment with responsible research and innovation: Towards a framework for Constructive Sustainability Assessment , 2019, Sustainable production and consumption.

[52]  S. Cutler,et al.  Where are the drought tolerant crops? An assessment of more than two decades of plant biotechnology effort in crop improvement. , 2018, Plant science : an international journal of experimental plant biology.

[53]  T. Lu,et al.  Genetically Engineered Phages: a Review of Advances over the Last Decade , 2016, Microbiology and Molecular Reviews.

[54]  Geoffrey S. Ginsburg,et al.  The Personalized Medicine Coalition , 2005, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.

[55]  G. Baynam,et al.  Optimizing Precision Medicine for Public Health , 2019, Front. Public Health.

[56]  Rainer Breitling,et al.  A transatlantic perspective on 20 emerging issues in biological engineering , 2017, eLife.

[58]  George Wright,et al.  The limits of forecasting methods in anticipating rare events , 2010 .

[59]  C. Nicholls,et al.  Agroecology and the design of climate change-resilient farming systems , 2015, Agronomy for Sustainable Development.

[60]  N. Ranson,et al.  Plant-Made Nervous Necrosis Virus-Like Particles Protect Fish Against Disease , 2019, Front. Plant Sci..

[61]  David J. Wu,et al.  Secure genome-wide association analysis using multiparty computation , 2018, Nature Biotechnology.

[62]  D. Bromwich,et al.  Sustained Antarctic Research: A 21st Century Imperative , 2019, One Earth.

[63]  Mark A. Burgman,et al.  I nvestigate D iscuss E stimate A ggregate for structured expert judgement , 2017 .

[64]  M. Levine,et al.  Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes. , 2000, The Journal of infectious diseases.

[65]  Oliver Gassmann,et al.  Leading Pharmaceutical Innovation: How to Win the Life Science Race , 2018 .

[66]  Jeffrey R. Powell,et al.  Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population , 2019, Scientific Reports.

[67]  J. Marchesi,et al.  Mobile genetic elements of the human gastrointestinal tract , 2013, Gut microbes.

[68]  Yong Wang,et al.  Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 , 2017, Science.

[69]  Daniela Liggett,et al.  Polar research: Six priorities for Antarctic science , 2014, Nature.

[70]  Jee Loon Foo,et al.  Microbiome engineering: Current applications and its future. , 2017, Biotechnology journal.

[71]  Emma J. Chory,et al.  A Deep Learning Approach to Antibiotic Discovery , 2020, Cell.

[72]  R. Milo,et al.  Conversion of Escherichia coli to Generate All Biomass Carbon from CO2 , 2019, Cell.

[73]  C. Gross,et al.  The impact of disclosing financial ties in research and clinical care: a systematic review. , 2010, Archives of internal medicine.

[74]  S. Brady,et al.  Evolutionary flexibility in flooding response circuitry in angiosperms , 2019, Science.

[75]  Dan S. Tawfik,et al.  Design and in vitro realization of carbon-conserving photorespiration , 2018, Proceedings of the National Academy of Sciences.

[76]  B. Munos,et al.  Can Open‐Source Drug R&D Repower Pharmaceutical Innovation? , 2010, Clinical pharmacology and therapeutics.

[77]  Harris H. Wang,et al.  Metagenomic engineering of the mammalian gut microbiome in situ , 2018, Nature Methods.

[78]  Alfredo Yegros,et al.  Is Research Responding to Health Needs? , 2017 .

[79]  David W. Macdonald,et al.  The identification of 100 ecological questions of high policy relevance in the UK , 2006 .

[80]  Jules Pretty,et al.  A 2017 Horizon Scan of Emerging Issues for Global Conservation and Biological Diversity. , 2017, Trends in ecology & evolution.