The Hypocretins (Orexins)

[1]  T. Sakurai,et al.  Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions , 2005, Neuroscience Letters.

[2]  T. Horvath.  The hardship of obesity: a soft-wired hypothalamus , 2005, Nature Neuroscience.

[3]  M. Yanagisawa,et al.  Persistent pain and stress activate pain-inhibitory orexin pathways , 2005, Neuroreport.

[4]  C. Berridge,et al.  Diurnal levels of Fos immunoreactivity are elevated within hypocretin neurons in lactating mice , 2004, Peptides.

[5]  H. Randeva,et al.  Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. , 2004, Molecular endocrinology.

[6]  S Overeem,et al.  Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men. , 2004, American journal of physiology. Endocrinology and metabolism.

[7]  Weontae Lee,et al.  Solution structure of human orexin-A: regulator of appetite and wakefulness. , 2004, Journal of biochemistry and molecular biology.

[8]  V. Luca,et al.  Injection of orexin A into the diagonal band of Broca induces symphatetic and hyperthermic reactions , 2004, Brain Research.

[9]  S. Leibowitz,et al.  Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus. , 2004, Endocrinology.

[10]  A. Wirz-Justice,et al.  Orexins and Their Receptors in the Human Retina , 2004, Pathobiology.

[11]  R. Benca,et al.  Comparison of hypocretin/orexin and melanin-concentrating hormone neurons and axonal projections in the embryonic and postnatal rat brain , 2004, Journal of Chemical Neuroanatomy.

[12]  T. Bartsch,et al.  Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area , 2004, Pain.

[13]  J. Toppari,et al.  Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis. , 2004, Endocrinology.

[14]  Y. Li,et al.  Hypothalamus-brain stem circuitry responsible for vagal efferent signaling to the pancreas evoked by hypoglycemia in rat. , 2004, Journal of neurophysiology.

[15]  O. Yuge,,et al.  Analgesic effect of intrathecal administration of orexin on neuropathic pain in rats. , 2004, In vivo.

[16]  A. Levine,et al.  Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding , 2004, Peptides.

[17]  T. Higuchi,et al.  Orexin A Elicits Arousal Electroencephalography Without Sympathetic Cardiovascular Activation in Isoflurane-Anesthetized Rats , 2003, Anesthesia and analgesia.

[18]  M. Kudo,et al.  Orexinergic neurons and barbiturate anesthesia , 2003, Neuroscience.

[19]  F. Fujiyama,et al.  Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight , 2003, The European journal of neuroscience.

[20]  Kazuhiro Takahashi,et al.  Orexin-A expression in human peripheral tissues , 2003, Molecular and Cellular Endocrinology.

[21]  C. Saper,et al.  Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats , 2003, Neuroscience.

[22]  P. Morgan,et al.  Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin , 2003, Neuroscience.

[23]  Takeshi Sakurai,et al.  Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice , 2003, Neuron.

[24]  Jon T. Willie,et al.  Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice Molecular Genetic Dissection of Non-REM and REM Sleep Regulatory Processes , 2003, Neuron.

[25]  S. Leibowitz,et al.  Peptides That Regulate Food Intake Orexin Gene Expression Is Increased during States of Hypertriglyceridemia , 2003 .

[26]  Jon T. Willie,et al.  Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal , 2003, The Journal of Neuroscience.

[27]  A. Deutch,et al.  Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area , 2002, Neuroscience.

[28]  C. Leonard,et al.  Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy , 2002, The Journal of Neuroscience.

[29]  H. Haas,et al.  Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro , 2002, Regulatory Peptides.

[30]  L. Lecea,et al.  Interaction of the hypocretins with neurotransmitters in the nucleus accumbens , 2002, Regulatory Peptides.

[31]  J. Forteza,et al.  Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas , 2002, Regulatory Peptides.

[32]  J. Yesavage,et al.  CSF hypocretin/orexin levels in narcolepsy and other neurological conditions , 2001, Neurology.

[33]  S. Bloom,et al.  Orexin A interactions in the hypothalamo-pituitary gonadal axis. , 2001, Endocrinology.

[34]  M. M. Taylor,et al.  Hypocretin/orexin suppresses corticotroph responsiveness in vitro. , 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

[35]  H. Randeva,et al.  Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. , 2001, The Journal of clinical endocrinology and metabolism.

[36]  T. Kilduff,et al.  Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat , 2001, The Journal of Neuroscience.

[37]  J. Sutcliffe,et al.  Hypocretin (orexin) in the rat pineal gland: a central transmitter with effects on noradrenaline‐induced release of melatonin , 2001, The European journal of neuroscience.

[38]  M. Takigawa,et al.  Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area , 2001, Neuroreport.

[39]  J. Kukkonen,et al.  Orexin receptors couple to Ca2+ channels different from store-operated Ca2+ channels , 2001, Neuroreport.

[40]  F. Casanueva,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Cellular Localization of Orexin Receptors in , 2000 .

[41]  L. de Lecea,et al.  Mapping of the mRNAs for the hypocretin/orexin and melanin‐concentrating hormone receptors: Networks of overlapping peptide systems , 2001, The Journal of comparative neurology.

[42]  C. Saper,et al.  Differential expression of orexin receptors 1 and 2 in the rat brain , 2001, The Journal of comparative neurology.

[43]  D. Buxton,et al.  Effect of intracerebroventricular orexin-B on food intake in sheep. , 2001, Journal of animal science.

[44]  A. A. Parsons,et al.  Orexin-A, an hypothalamic peptide with analgesic properties , 2001, Pain.

[45]  Shelagh Wilson,et al.  Central Orexin‐A Activates Hypothalamic‐Pituitary‐Adrenal Axis and Stimulates Hypothalamic Corticotropin Releasing Factor and Arginine Vasopressin Neurones in Conscious Rats , 2001, Journal of neuroendocrinology.

[46]  Jon T. Willie,et al.  Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity , 2001, Neuron.

[47]  Emmanuel Mignot,et al.  Hypocretin/orexin, sleep and narcolepsy , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[48]  E. Mignot,et al.  Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation , 2001, Neuroreport.

[49]  A. N. van den Pol,et al.  The hypocretin neuron system: an arousal system in the human brain. , 2001, Archives italiennes de biologie.

[50]  J. Roberts,et al.  Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord , 2001, Neuroscience.

[51]  N Risch,et al.  Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. , 2001, American journal of human genetics.

[52]  A. N. van den Pol,et al.  Immunohistochemical localization and biochemical characterization of hypocretin/orexin‐related peptides in the central nervous system of the frog Rana ridibunda , 2001, The Journal of comparative neurology.

[53]  G. Yoshimichi,et al.  Orexin-A Regulates Body Temperature in Coordination with Arousal Status , 2001, Experimental biology and medicine.

[54]  M. Nakazato,et al.  Both corticotropin releasing factor and neuropeptide Y are involved in the effect of orexin (hypocretin) on the food intake in rats , 2000, Neuroscience Letters.

[55]  Luis de Lecea,et al.  Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons , 2000, The Journal of Neuroscience.

[56]  C. Blaha,et al.  Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area , 2000, The European journal of neuroscience.

[57]  Michael Aldrich,et al.  Reduced Number of Hypocretin Neurons in Human Narcolepsy , 2000, Neuron.

[58]  Sebastiaan Overeem,et al.  A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains , 2000, Nature Medicine.

[59]  A. Yamanaka,et al.  Orexin-induced food intake involves neuropeptide Y pathway , 2000, Brain Research.

[60]  N. Dun,et al.  Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[61]  A. Hunter,et al.  The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats , 2000, The European journal of neuroscience.

[62]  Sebastiaan Overeem,et al.  Hypocretin (orexin) deficiency in human narcolepsy , 2000, The Lancet.

[63]  E. Bang,et al.  Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. , 1999, European journal of biochemistry.

[64]  A. Yamanaka,et al.  Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight , 1999, Brain Research.

[65]  A. Kirchgessner,et al.  Orexin Synthesis and Response in the Gut , 1999, Neuron.

[66]  H. Volkoff,et al.  Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B , 1999, Brain Research.

[67]  M. Nakazato,et al.  Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models , 1999, Neuroscience Letters.

[68]  M. I. Smith,et al.  Orexin A activates locus coeruleus cell firing and increases arousal in the rat. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[69]  D. Middlemiss,et al.  Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR , 1999, British journal of pharmacology.

[70]  A. Yamanaka,et al.  Orexins/hypocretins regulate drinking behaviour 1 Published on the World Wide Web on 4 August 1999. 1 , 1999, Brain Research.

[71]  M. G. Dube,et al.  Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action 1 This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998. 1 , 1999, Brain Research.

[72]  Emmanuel Mignot,et al.  The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene , 1999, Cell.

[73]  Jon T. Willie,et al.  Narcolepsy in orexin Knockout Mice Molecular Genetics of Sleep Regulation , 1999, Cell.

[74]  T. Sakurai,et al.  Structure and Function of Human Prepro-orexin Gene* , 1999, The Journal of Biological Chemistry.

[75]  W. Samson,et al.  Cardiovascular regulatory actions of the hypocretins in brain , 1999, Brain Research.

[76]  A. Pol.  Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord , 1999 .

[77]  A. N. van den Pol,et al.  Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations , 1999, The Journal of Neuroscience.

[78]  A. N. van den Pol,et al.  Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems , 1998, The Journal of Neuroscience.

[79]  A. N. van den Pol,et al.  Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin , 1998, The Journal of Neuroscience.

[80]  S. Carr,et al.  Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior , 1998, Cell.

[81]  F E Bloom,et al.  The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[82]  F E Bloom,et al.  Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[83]  S. Gammeltoft,et al.  A role for melanin-concentrating hormone in the central regulation of feeding behaviour , 1996, Nature.

[84]  W. Corrigall.  Heroin self-administration: Effects of antagonist treatment in lateral hypothalamus , 1987, Pharmacology Biochemistry and Behavior.

[85]  A. Gronenborn,et al.  A 1H‐NMR study of the solution conformation of secretin resonance assignment and secondary structure , 1987, FEBS letters.

[86]  N. Upton.  In Vivo Pharmacology of Orexin (Hypocretin) Receptors , 2005 .

[87]  Jon T. Willie,et al.  To eat or to sleep? Orexin in the regulation of feeding and wakefulness. , 2001, Annual review of neuroscience.

[88]  J. Hagan,et al.  Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity , 2000, Psychopharmacology.