Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance.
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V. Demarco | J. Sowers | Guanghong Jia | S. McKarns | A. Aroor | V. DeMarco
[1] U. Laufs,et al. Effects of DPP-4 inhibition on cardiac metabolism and function in mice. , 2011, Journal of molecular and cellular cardiology.
[2] M. McCarthy,et al. The Genetic and Epigenetic Basis of Type 2 Diabetes and Obesity , 2012, Clinical pharmacology and therapeutics.
[3] L. Joosten,et al. The inflammasome puts obesity in the danger zone. , 2012, Cell metabolism.
[4] R. Orlando,et al. The genetics of childhood obesity and interaction with dietary macronutrients , 2013, Genes & Nutrition.
[5] D. Harrison,et al. Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction , 2010, Hypertension.
[6] D. O’Regan,et al. Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age , 2013, Hypertension.
[7] Y. Terauchi,et al. Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice , 2011, Diabetes.
[8] J. Bloodworth. Diabetes mellitus and vascular disease. , 1973, Postgraduate medicine.
[9] J. van de Voorde,et al. Adipose Tissue as Regulator of Vascular Tone , 2012, Current Hypertension Reports.
[10] R. Witteles,et al. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. , 2008, Journal of the American College of Cardiology.
[11] R. Sacco,et al. Arterial Stiffness and Wave Reflection: Sex Differences and Relationship With Left Ventricular Diastolic Function , 2012, Hypertension.
[12] François M Abboud,et al. Autonomic Neural Regulation of the Immune System: Implications for Hypertension and Cardiovascular Disease , 2012, Hypertension.
[13] J. Sowers,et al. Loss of Estrogen Receptor α Signaling Leads to Insulin Resistance and Obesity in Young and Adult Female Mice , 2012, Cardiorenal Medicine.
[14] V. Somers,et al. Effects of Renal Sympathetic Denervation on Blood Pressure, Sleep Apnea Course, and Glycemic Control in Patients With Resistant Hypertension and Sleep Apnea , 2011, Hypertension.
[15] K. Stanhope. Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome. , 2012, Annual review of medicine.
[16] R. Schwendener,et al. Macrophages modulate cardiac function in lipotoxic cardiomyopathy. , 2012, American journal of physiology. Heart and circulatory physiology.
[17] 熊谷 英太. Plasma aldosterone levels and development of insulin resistance : prospective study in a general population , 2012 .
[18] C. Apovian,et al. Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes , 2011, The Journal of Immunology.
[19] S. Shoelson,et al. Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets , 2012, Arteriosclerosis, thrombosis, and vascular biology.
[20] R. Webb,et al. The influence of perivascular adipose tissue on vascular homeostasis , 2013, Vascular health and risk management.
[21] J. Sowers,et al. Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation. , 2012, American journal of physiology. Endocrinology and metabolism.
[22] J. Sowers,et al. The Role of Overweight and Obesity in the Cardiorenal Syndrome , 2011, Cardiorenal Medicine.
[23] G. Fantuzzi,et al. New pathways to control inflammatory responses in adipose tissue. , 2013, Current opinion in pharmacology.
[24] W. Abhayaratna,et al. Influence of Adiposity and Physical Activity on Arterial Stiffness in Healthy Children: The Lifestyle of Our Kids Study , 2009, Hypertension.
[25] J. Sowers,et al. Indices of obesity and cardiometabolic risk. , 2011, Hypertension.
[26] D. Jacobs,et al. Plasma Aldosterone Levels and Development of Insulin Resistance: Prospective Study in a General Population , 2011, Hypertension.
[27] Lin Qiu,et al. Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice , 2011, Immunology and cell biology.
[28] K. E. Jones,et al. Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart , 2009, Diabetes.
[29] N. Kalupahana,et al. Immunity as a link between obesity and insulin resistance. , 2012, Molecular aspects of medicine.
[30] J. Higaki,et al. Roles of Interleukin 17 in Angiotensin II Type 1 Receptor–Mediated Insulin Resistance , 2012, Hypertension.
[31] C. Ross,et al. Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. , 2005, American journal of physiology. Heart and circulatory physiology.
[32] G. Cline,et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. , 2004, Diabetes.
[33] J. Sowers,et al. Mineralocorticoid Receptor–Mediated Vascular Insulin Resistance , 2013, Diabetes.
[34] S. Rajagopalan,et al. Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis , 2011, Circulation.
[35] E. Schiffrin,et al. Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities , 2012, International journal of hypertension.
[36] B. Rothermel,et al. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. , 2005, Diabetes.
[37] J. Sowers,et al. Aldosterone and Risk for Insulin Resistance. , 2011, Hypertension.
[38] Melinda Fitzgerald,et al. Immunol. Cell Biol. , 1995 .
[39] V. V. van Hinsbergh,et al. Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue. , 2012, Vascular pharmacology.
[40] B. Howard,et al. Sex differences in obesity-related changes in left ventricular morphology: the Strong Heart Study , 2011, Journal of hypertension.
[41] T. Berl,et al. An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials , 2012, Journal of hypertension.
[42] M. Yeh,et al. Increased Aortic Stiffness and Attenuated Lysyl Oxidase Activity in Obesity , 2013, Arteriosclerosis, thrombosis, and vascular biology.
[43] H. Krum,et al. Sympatho-renal axis in chronic disease , 2011, Clinical Research in Cardiology.
[44] Eduardo Nava,et al. Hypertension in Metabolic Syndrome: Vascular Pathophysiology , 2013, International journal of hypertension.
[45] P. Puddu,et al. Relationships among hyperuricemia, endothelial dysfunction and cardiovascular disease: molecular mechanisms and clinical implications. , 2012, Journal of cardiology.
[46] J. Sowers,et al. Relation between Childhood Obesity and Adult Cardiovascular Risk , 2009, International journal of pediatric endocrinology.
[47] K. Siminovitch,et al. Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells , 2010, Diabetologia.
[48] R. Friedline,et al. Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle , 2009, Diabetes.
[49] E. Barrett-Connor,et al. Women and heart disease: the role of diabetes and hyperglycemia. , 2004, Archives of internal medicine.
[50] V. Demarco,et al. Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice. , 2013, Endocrinology.
[51] K. Fitzgerald,et al. Regulation of inflammasome signaling , 2012, Nature Immunology.
[52] E. Paschetta,et al. Probiotics, prebiotics, energy balance, and obesity: mechanistic insights and therapeutic implications. , 2012, Gastroenterology Clinics of North America.
[53] P. Ricciardi-Castagnoli,et al. Uric Acid-Driven Th17 Differentiation Requires Inflammasome-Derived IL-1 and IL-18 , 2011, The Journal of Immunology.
[54] E. Schiffrin,et al. T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury , 2012, Hypertension.
[55] E. Schiffrin. The immune system: role in hypertension. , 2013, The Canadian journal of cardiology.
[56] Hyung-Suk Kim,et al. Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta. , 2009, Endocrinology.
[57] T. Miura,et al. Effects of Parental Hypertension on Longitudinal Trends in Blood Pressure and Plasma Metabolic Profile: Mixed-Effects Model Analysis , 2012, Hypertension.
[58] D. Harrison,et al. Vascular Inflammatory Cells in Hypertension , 2012, Front. Physio..
[59] R. Charnigo,et al. Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice , 2012, Hypertension.
[60] V. Demarco,et al. Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. , 2012, American journal of physiology. Heart and circulatory physiology.
[61] K. Brown,et al. Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease , 2012, Nutrients.
[62] G. Hu,et al. Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. , 2007, Life sciences.
[63] E. D. du Toit,et al. Dietary-Induced Obesity Hastens the Progression From Concentric Cardiac Hypertrophy to Pump Dysfunction in Spontaneously Hypertensive Rats , 2009, Hypertension.
[64] T. Hosoya,et al. Effects of combined antihypertensive therapy with losartan/hydrochlorothiazide on uric acid metabolism. , 2012, Internal medicine.
[65] D. Clegg,et al. Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors , 2011, Acta physiologica.
[66] Ling Qi,et al. Mechanisms of inflammatory responses in obese adipose tissue. , 2012, Annual review of nutrition.
[67] M. Trebak,et al. Interleukin-10 Released by CD4+CD25+ Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice , 2011, Arteriosclerosis, thrombosis, and vascular biology.
[68] Liping Zhao,et al. The gut microbiota, obesity and insulin resistance. , 2013, Molecular aspects of medicine.
[69] V. Z. Rocha,et al. Inflammatory Concepts of Obesity , 2011, International journal of inflammation.
[70] V. J. Dias da Silva,et al. The interplay between the autonomic and immune systems , 2012, Experimental physiology.
[71] Christophe Benoist,et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters , 2009, Nature Medicine.
[72] U. Kintscher,et al. Metabolic impact of estrogen signalling through ERalpha and ERbeta , 2010, The Journal of Steroid Biochemistry and Molecular Biology.
[73] J. Sowers,et al. Oxidative Stress in the Cardiorenal Metabolic Syndrome , 2012, Current Hypertension Reports.
[74] F. Luft,et al. Immune mechanisms in angiotensin II-induced target-organ damage , 2012, Annals of medicine.
[75] R. M. Lee,et al. Superoxide anion mediates angiotensin II-induced potentiation of contractile response to sympathetic stimulation. , 2008, European journal of pharmacology.
[76] A. McCullough. Epidemiology of the metabolic syndrome in the USA , 2011, Journal of digestive diseases.
[77] J. Olefsky,et al. The Origins and Drivers of Insulin Resistance , 2013, Cell.
[78] T. Marwick,et al. Obesity cardiomyopathy: pathogenesis and pathophysiology , 2007, Nature Clinical Practice Cardiovascular Medicine.
[79] T. Momose,et al. Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[80] G. Remuzzi,et al. Angiotensin II revisited: new roles in inflammation, immunology and aging , 2010, EMBO molecular medicine.
[81] C. Abbott,et al. Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? , 2009, Trends in pharmacological sciences.
[82] H. Krum,et al. Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension: A Pilot Study , 2011, Circulation.
[83] C. Weyand,et al. Induction of hypertension and peripheral inflammation by deletion of extracellular superoxide dismutase in the central nervous system , 2010, Hypertension.
[84] S. H. Kim,et al. CD26/DPP4 levels in peripheral blood and T cells in patients with type 2 diabetes mellitus. , 2013, The Journal of clinical endocrinology and metabolism.
[85] W. Patsch,et al. Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy , 2011, Diabetes.
[86] A. Nishiyama,et al. Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome. , 2012, Endocrinology.
[87] M. Febbraio,et al. Myeloid-specific estrogen receptor α deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development , 2011, Proceedings of the National Academy of Sciences.
[88] V. Demarco,et al. Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats. , 2013, Endocrinology.
[89] J. Sowers,et al. Insulin resistance and heart failure: molecular mechanisms. , 2012, Heart failure clinics.
[90] G. Reaven. Insulin resistance: the link between obesity and cardiovascular disease. , 2011, The Medical clinics of North America.
[91] E. Abel,et al. Insulin resistance: metabolic mechanisms and consequences in the heart. , 2012, Arteriosclerosis, thrombosis, and vascular biology.
[92] D. Panagiotakos,et al. Exercise Capacity and Progression From Prehypertension to Hypertension , 2012, Hypertension.
[93] J. Murabito,et al. Relations of Serum Aldosterone to Cardiac Structure: Gender-Related Differences in the Framingham Heart Study , 2004, Hypertension.
[94] C. Delcayre,et al. Aldosterone Mediates Cardiac Fibrosis in the Setting of Hypertension , 2013, Current Hypertension Reports.
[95] F. Dazzi,et al. Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? , 2013, Immunology and cell biology.
[96] R. Gropler,et al. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. , 2004, Journal of the American College of Cardiology.
[97] Jason K. Kim,et al. New insights into insulin resistance in the diabetic heart , 2011, Trends in Endocrinology & Metabolism.
[98] Wei Xu,et al. Differential Macrophage Polarization in Male and Female BALB/c Mice Infected With Coxsackievirus B3 Defines Susceptibility to Viral Myocarditis , 2009, Circulation research.