Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke

To find sequence variants that associate with the risk for ischemic stroke (IS), we performed a genome‐wide association study.

[1]  Albert R. Singleton,et al.  The genetics of ischaemic stroke , 2010, Journal of internal medicine.

[2]  G. Lip,et al.  Atrial fibrillation and stroke prevention , 2007, The Lancet Neurology.

[3]  Eric E. Smith,et al.  Variants conferring risk of atrial fibrillation on chromosome 4q25 , 2007, Nature.

[4]  M. Aguilar,et al.  Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation , 2007, Annals of Internal Medicine.

[5]  Richard P. Harvey,et al.  Molecular Pathway for the Localized Formation of the Sinoatrial Node , 2007, Circulation research.

[6]  C. Mathers,et al.  Preventing stroke: saving lives around the world , 2007, The Lancet Neurology.

[7]  U. John,et al.  The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case–control studies , 2007, Human Genetics.

[8]  E. Lukhtanov,et al.  A novel endonuclease IV post-PCR genotyping system , 2006, Nucleic acids research.

[9]  Gregory Y H Lip,et al.  Management of atrial fibrillation , 2006, Heart.

[10]  G. Lip,et al.  Antithrombotic treatment in atrial fibrillation , 2005, Postgraduate Medical Journal.

[11]  C. Gieger,et al.  KORA-gen - Resource for Population Genetics, Controls and a Broad Spectrum of Disease Phenotypes , 2005 .

[12]  H. Markus.  Genes for stroke , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[13]  Theodor Landis,et al.  Usefulness of Ambulatory 7-Day ECG Monitoring for the Detection of Atrial Fibrillation and Flutter After Acute Stroke and Transient Ischemic Attack , 2004, Stroke.

[14]  P. Rothwell,et al.  Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke , 2003, Stroke.

[15]  Mark Gurney,et al.  The gene encoding phosphodiesterase 4D confers risk of ischemic stroke , 2003, Nature Genetics.

[16]  J. Barthélémy,et al.  Automatic Cardiac Event Recorders Reveal Paroxysmal Atrial Fibrillation after Unexplained Strokes or Transient Ischemic Attacks , 2003, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[17]  Geoffrey Cloud,et al.  Evaluating the Genetic Component of Ischemic Stroke Subtypes: A Family History Study , 2003, Stroke.

[18]  A. Minagar,et al.  Cardioembolic Stroke: An Update , 2003, Southern medical journal.

[19]  D. Singer,et al.  Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. , 2001, JAMA.

[20]  T. Lepage,et al.  The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. . , 2001, Developmental biology.

[21]  H. Markus,et al.  Genetics and ischaemic stroke. , 2000, Brain : a journal of neurology.

[22]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[23]  D. Singer,et al.  Preventing stroke in atrial fibrillation. , 1997, American family physician.

[24]  E. Vartiainen,et al.  Parental history of cardiovascular disease and risk of stroke. A prospective follow-up of 14371 middle-aged men and women in Finland. , 1997, Stroke.

[25]  D. Ganten,et al.  Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease , 1996, Nature Genetics.

[26]  A Laupacis,et al.  Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. , 1995, Archives of internal medicine.

[27]  David Lee Gordon,et al.  Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial , 1993, Stroke.

[28]  K. Merikangas,et al.  A Study of Twins and Stroke , 1992, Stroke.

[29]  P. Wolf,et al.  Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. , 1991, Stroke.

[30]  Lippincott Williams Wilkins,et al.  Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. , 1989, Stroke.

[31]  A. Belanger,et al.  The Framingham study. , 1976, British medical journal.

[32]  W. Haenszel,et al.  Statistical aspects of the analysis of data from retrospective studies of disease. , 1959, Journal of the National Cancer Institute.