Non-Smad signaling pathways
暂无分享,去创建一个
[1] A. Hinck,et al. TGF‐β signalling is mediated by two autonomously functioning TβRI:TβRII pairs , 2011, The EMBO journal.
[2] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[3] Xiaohua Yan,et al. Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling. , 2011, The Biochemical journal.
[4] Wei Li,et al. TβRI/Alk5-independent TβRII signaling to ERK1/2 in human skin cells according to distinct levels of TβRII expression , 2011, Journal of Cell Science.
[5] C. Albanese,et al. Smad7 restricts melanoma invasion by restoring N‐cadherin expression and establishing heterotypic cell–cell interactions in vivo , 2010, Pigment cell & melanoma research.
[6] C. Brendler,et al. Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor. , 2010, Urology.
[7] A. Moustakas,et al. TGFβ Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death* , 2010, The Journal of Biological Chemistry.
[8] Samy Lamouille,et al. Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition , 2010, Cells Tissues Organs.
[9] C. Heldin,et al. Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1* , 2010, The Journal of Biological Chemistry.
[10] K. Miyazono,et al. Smad7 Inhibits Transforming Growth Factor-β Family Type I Receptors through Two Distinct Modes of Interaction* , 2010, The Journal of Biological Chemistry.
[11] Michael D. Schneider,et al. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. , 2010, The Journal of clinical investigation.
[12] X. Fang,et al. Monomeric type I and type III transforming growth factor-β receptors and their dimerization revealed by single-molecule imaging , 2010, Cell Research.
[13] Kohei Miyazono,et al. TGFβ signalling: a complex web in cancer progression , 2010, Nature Reviews Cancer.
[14] Thomas J. Fuchs,et al. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. , 2010, Cancer cell.
[15] M. Landström. The TAK1-TRAF6 signalling pathway. , 2010, The international journal of biochemistry & cell biology.
[16] M. Karin,et al. Immunity, Inflammation, and Cancer , 2010, Cell.
[17] M. Karin,et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. , 2010, Cancer cell.
[18] A. Sonnenberg,et al. Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing , 2010 .
[19] Hiroshi I. Suzuki,et al. Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells. , 2009, Cancer research.
[20] Qianqian Wang,et al. Single-molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization , 2009, Proceedings of the National Academy of Sciences.
[21] R. Shaw. Tumor Suppression by LKB1: SIK-ness Prevents Metastasis , 2009, Science Signaling.
[22] R. Derynck,et al. New regulatory mechanisms of TGF-beta receptor function. , 2009, Trends in cell biology.
[23] E. Wagner,et al. Signal integration by JNK and p38 MAPK pathways in cancer development , 2009, Nature Reviews Cancer.
[24] W. Hahn,et al. SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis , 2009, Science Signaling.
[25] Samy Lamouille,et al. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. , 2009, Molecular cell.
[26] W. B. Derry. Faculty Opinions recommendation of A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. , 2009 .
[27] Antonio Rosato,et al. A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis , 2009, Cell.
[28] C. Heldin,et al. Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. , 2009, Current opinion in cell biology.
[29] Roger J. Davis,et al. Regulation of the immune response by stress‐activated protein kinases , 2009, Immunological reviews.
[30] Leonardo Morsut,et al. FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination , 2009, Cell.
[31] C. Heldin,et al. The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner , 2008, Nature Cell Biology.
[32] M. Yamashita,et al. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. , 2008, Molecular cell.
[33] E. Bradley,et al. TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. , 2008, Experimental cell research.
[34] C. Heldin,et al. Jcb: Report , 2022 .
[35] Y. Chai,et al. Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. , 2008, Developmental cell.
[36] J. Massagué,et al. TGFβ in Cancer , 2008, Cell.
[37] P. Thompson,et al. Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway* , 2008, Journal of Biological Chemistry.
[38] W. Schiemann,et al. Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. , 2008, Cancer research.
[39] Vandana Iyer,et al. Integrin α3β1 potentiates TGFβ-mediated induction of MMP-9 in immortalized keratinocytes , 2008 .
[40] A. Hinck,et al. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. , 2008, Molecular cell.
[41] Jing Qing,et al. TGF‐β activates Erk MAP kinase signalling through direct phosphorylation of ShcA , 2007 .
[42] Samy Lamouille,et al. Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway , 2007, The Journal of cell biology.
[43] Zhijian J. Chen,et al. Ubiquitin-mediated activation of TAK1 and IKK , 2007, Oncogene.
[44] O. Rath,et al. MAP kinase signalling pathways in cancer , 2007, Oncogene.
[45] W. Schiemann,et al. Src phosphorylates Tyr284 in tgf-β type II receptor and regulates TGF-β stimulation of p38 MAPK during breast cancer cell proliferation and invasion , 2007 .
[46] T. Luedde,et al. Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma , 2007 .
[47] Stefano Piccolo,et al. Integration of TGF-ß and Ras/MAPK Signaling Through p53 Phosphorylation , 2007, Science.
[48] C. Heldin,et al. TGFβ1-Induced Activation of ATM and p53 Mediates Apoptosis in a Smad7-Dependent Manner , 2006, Cell cycle.
[49] Michael D. Schneider,et al. A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway , 2006, Proceedings of the National Academy of Sciences.
[50] P. Dijke,et al. Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development , 2006 .
[51] Wei He,et al. Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ Pathway , 2006, Cell.
[52] J. Doré,et al. Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. , 2005, Cancer research.
[53] R. Derynck,et al. SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .
[54] C. Heldin,et al. Non-Smad TGF-β signals , 2005, Journal of Cell Science.
[55] V. Vasioukhin. Faculty Opinions recommendation of Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. , 2005 .
[56] Jae Youn Yi,et al. Type I Transforming Growth Factor β Receptor Binds to and Activates Phosphatidylinositol 3-Kinase* , 2005, Journal of Biological Chemistry.
[57] Yue Zhang,et al. Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity , 2005, Science.
[58] C. Heldin,et al. Interaction between Smad7 and β-Catenin: Importance for Transforming Growth Factor β-Induced Apoptosis , 2005, Molecular and Cellular Biology.
[59] C. Heldin,et al. Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42 , 2004, Journal of Cell Science.
[60] S. Murphy,et al. Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3 , 2003, Molecular and Cellular Biology.
[61] C. Heldin,et al. Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. , 2003, Molecular biology of the cell.
[62] T. Hunter,et al. The Protein Kinase Complement of the Human Genome , 2002, Science.
[63] C. Zimmerman,et al. Modulation of Smad2-mediated Signaling by Extracellular Signal-regulated Kinase* , 2002, The Journal of Biological Chemistry.
[64] F. Lallemand,et al. c-Jun Associates with the Oncoprotein Ski and Suppresses Smad2 Transcriptional Activity* , 2002, The Journal of Biological Chemistry.
[65] C. Heldin,et al. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. , 2002, Molecular biology of the cell.
[66] L. Wakefield,et al. TGF-β signaling: positive and negative effects on tumorigenesis , 2002 .
[67] J. Downward,et al. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis , 2002, The Journal of Cell Biology.
[68] Tomoki Chiba,et al. Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation* , 2001, The Journal of Biological Chemistry.
[69] J. Massagué,et al. Epidermal growth factor signaling via Ras controls the Smad transcriptional co‐repressor TGIF , 2001, The EMBO journal.
[70] H. Moses,et al. Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration* , 2000, The Journal of Biological Chemistry.
[71] J. Schlessinger,et al. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.
[72] J. Schlessinger. Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.
[73] C. Heldin,et al. Efficient TGF-β Induction of the Smad7 Gene Requires Cooperation between AP-1, Sp1, and Smad Proteins on the Mouse Smad7 Promoter* , 2000, The Journal of Biological Chemistry.
[74] D. He,et al. Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[75] Yan Chen,et al. Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4* , 1999, The Journal of Biological Chemistry.
[76] Hong-Jian Zhu,et al. Smad7 Differentially Regulates Transforming Growth Factor β-mediated Signaling Pathways* , 1999, The Journal of Biological Chemistry.
[77] N. Kaminski,et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.
[78] R. Derynck,et al. The Type II Transforming Growth Factor-β Receptor Autophosphorylates Not Only on Serine and Threonine but Also on Tyrosine Residues* , 1997, The Journal of Biological Chemistry.
[79] J. Massagué,et al. The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. , 1997, Genes & development.
[80] E. Kieff,et al. Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region* , 1996, The Journal of Biological Chemistry.
[81] Zhaodan Cao,et al. TRAF6 is a signal transducer for interleukin-1 , 1996, Nature.
[82] H. Beug,et al. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. , 1996, Genes & development.
[83] H. Nojima,et al. Phorbol Ester Inhibits the Phosphorylation of the Retinoblastoma Protein without Suppressing Cyclin D-associated Kinase in Vascular Smooth Muscle Cells (*) , 1996, The Journal of Biological Chemistry.
[84] K. Irie,et al. Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.
[85] K. Miyazono,et al. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. , 1994, The Journal of biological chemistry.
[86] Jeffrey L. Wrana,et al. Mechanism of activation of the TGF-β receptor , 1994, Nature.
[87] Xiao-Fan Wang,et al. Signaling cross-talk between TGF-β/BMP and other pathways , 2009, Cell Research.
[88] Mary E. Choi,et al. Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells* , 2009, The Journal of Biological Chemistry.
[89] Ying E Zhang,et al. Non-Smad pathways in TGF-β signaling , 2009, Cell Research.
[90] Vandana Iyer,et al. Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. , 2008, The Journal of investigative dermatology.
[91] T. Luedde,et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. , 2007, Cancer cell.
[92] Jing Qing,et al. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. , 2007, The EMBO journal.
[93] W. Schiemann,et al. Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. , 2007, Cancer research.
[94] Stefano Piccolo,et al. Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. , 2007, Science.
[95] J. Massagué,et al. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. , 2006, Cell.
[96] Xia Lin,et al. Smad7-induced beta-catenin degradation alters epidermal appendage development. , 2006, Developmental cell.
[97] C. Heldin,et al. Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. , 2005, Molecular and cellular biology.
[98] R. Derynck,et al. Specificity and versatility in tgf-beta signaling through Smads. , 2005, Annual review of cell and developmental biology.
[99] C. Heldin,et al. Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42. , 2004, Journal of cell science.
[100] L. Wakefield,et al. TGF-beta signaling: positive and negative effects on tumorigenesis. , 2002, Current opinion in genetics & development.
[101] J. Downward,et al. Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. , 2002, The Journal of cell biology.
[102] H. Moses,et al. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. , 2001, The Journal of biological chemistry.
[103] K. Miyazono,et al. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. , 1997, Nature.
[104] R Wieser,et al. Mechanism of activation of the TGF-beta receptor. , 1994, Nature.