Getting to the core of the matter

Engineering chylomicron vesicles to target drugs to the liver may provide effective new treatments for hepatitis B and other liver diseases (pages 221–225).

[1]  D. Meijer,et al.  Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein? , 1986, Hepatology.

[2]  M. Brunetto,et al.  Inhibition of hepatitis B virus replication by adenine arabinoside monophosphate coupled to lactosaminated albumin. Efficacy and minimal active dose. , 1994, Journal of hepatology.

[3]  C. Florén,et al.  Uptake and degradation of iodine-labelled chylomicron remnant particles by monolayers of rat hepatocytes. , 1978, The Biochemical journal.

[4]  C. Wu,et al.  Model for specific rescue of normal hepatocytes during methotrexate treatment of hepatic malignancy. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[5]  W. Zimmermann,et al.  Borna disease virus genome transcribed and expressed in psychiatric patients , 1995, Nature Medicine.

[6]  M. Tognon,et al.  Enhanced inhibition of virus DNA synthesis in hepatocytes by trifluorothymidine coupled to asialofetuin , 1979, FEBS letters.

[7]  A. Morell,et al.  The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. , 2006, Advances in enzymology and related areas of molecular biology.

[8]  J. D. de Vries,et al.  Selective inhibition of ectromelia virus DNA synthesis in hepatocytes by adenine‐9‐β‐D‐arabinofuranoside (ara‐A) and adenine‐9‐β‐D‐arabinofuranoside 5′‐monophosphate (ara‐AMP) conjugated to asialofetuin , 1980, FEBS letters.

[9]  D. Alpers,et al.  Asialoglycoprotein receptor mRNAs are expressed in most extrahepatic rat tissues during development. , 1993, American Journal of Physiology.

[10]  T. V. van Berkel,et al.  Visualization of the interaction of native and modified low density lipoproteins with isolated rat liver cells. , 1985, European Journal of Cell Biology.

[11]  A. Florence,et al.  Liposomes in drug delivery. Clinical, diagnostic and ophthalmic potential. , 1993, Drugs.

[12]  J. K. Kruijt,et al.  Selective liver targeting of antivirals by recombinant chylomicrons — a new therapeutic approach to hepatitis B , 1995, Nature Medicine.

[13]  J. Amsterdam,et al.  Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. , 1985, Science.

[14]  T. V. van Berkel,et al.  Lactosylated low density lipoprotein: a potential carrier for the site-specific delivery of drugs to Kupffer cells. , 1989, Molecular pharmacology.

[15]  C. Wu,et al.  Acetaminophen hepatotoxicity and targeted rescue: A model for specific chemotherapy of hepatocellular carcinoma , 1985, Hepatology.

[16]  B. E. Huber Late-stage spermatids are characterized by expression of the "liver-specific" asialoglycoprotein receptor, RHL-1. , 1992, Molecular pharmacology.