Myeloperoxidase Propagates Damage and is a Potential Therapeutic Target for Subacute Stroke

[1]  John W. Chen,et al.  Measuring Myeloperoxidase Activity in Biological Samples , 2013, PloS one.

[2]  D. Kratky,et al.  Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo , 2013, PloS one.

[3]  H. Kamel,et al.  Brain-immune interactions and ischemic stroke: clinical implications. , 2012, Archives of neurology.

[4]  R. Weissleder,et al.  Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target. , 2012, Radiology.

[5]  Jeffrey L Saver,et al.  Stroke Declines From Third to Fourth Leading Cause of Death in the United States: Historical Perspective and Challenges Ahead , 2011, Stroke.

[6]  C. Detter,et al.  Myeloperoxidase deficiency preserves vasomotor function in humans , 2011, European heart journal.

[7]  C. Iadecola,et al.  The immunology of stroke: from mechanisms to translation , 2011, Nature Medicine.

[8]  M. Sperandio,et al.  Myeloperoxidase attracts neutrophils by physical forces. , 2011, Blood.

[9]  Eng H. Lo,et al.  The Science of Stroke: Mechanisms in Search of Treatments , 2010, Neuron.

[10]  Ralph Weissleder,et al.  Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. , 2010, Journal of the American Chemical Society.

[11]  D. Chuang,et al.  The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain , 2009, Journal of neurochemistry.

[12]  Ralph Weissleder,et al.  Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase , 2008, Proceedings of the National Academy of Sciences.

[13]  J. Filep,et al.  Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation , 2008, Circulation research.

[14]  S. Hazen,et al.  Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[15]  R. Balaraman,et al.  ANTI‐OXIDANT ACTIVITY MEDIATED NEUROPROTECTIVE POTENTIAL OF TRIMETAZIDINE ON FOCAL CEREBRAL ISCHAEMIA–REPERFUSION INJURY IN RATS , 2008, Clinical and experimental pharmacology & physiology.

[16]  R. Weissleder,et al.  Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. , 2008, Brain : a journal of neurology.

[17]  M. Chiariello,et al.  Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease. , 2007, European heart journal.

[18]  HisaoOgawa,et al.  Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously Hypertensive Rats, Independently of Blood Pressure , 2007 .

[19]  V. Cameron,et al.  Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. , 2007, Journal of the American College of Cardiology.

[20]  B. McColl,et al.  Systemic Inflammatory Stimulus Potentiates the Acute Phase and CXC Chemokine Responses to Experimental Stroke and Exacerbates Brain Damage via Interleukin-1- and Neutrophil-Dependent Mechanisms , 2007, The Journal of Neuroscience.

[21]  S. Hazen,et al.  Plasma myeloperoxidase levels in patients with chronic heart failure. , 2006, The American journal of cardiology.

[22]  Ralph Weissleder,et al.  Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. , 2006, Radiology.

[23]  S. Baldus,et al.  Myeloperoxidase and its contributory role in inflammatory vascular disease. , 2006, Pharmacology & therapeutics.

[24]  Jun Chen,et al.  Neuroprotection against focal ischemic brain injury by the peroxisome proliferator‐activated receptor‐γ agonist rosiglitazone , 2006, Journal of neurochemistry.

[25]  S. Klebanoff Myeloperoxidase: friend and foe , 2005, Journal of leukocyte biology.

[26]  M. Moskowitz,et al.  Exciting, radical, suicidal: how brain cells die after stroke. , 2005, Stroke.

[27]  D. Cornfield,et al.  Myeloperoxidase deficiency enhances inflammation after allogeneic marrow transplantation. , 2004, American journal of physiology. Lung cellular and molecular physiology.

[28]  R. Sacco,et al.  Leukocyte count predicts outcome after ischemic stroke: the Northern Manhattan Stroke Study. , 2004, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[29]  G. Siest,et al.  Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome. , 2003, Atherosclerosis.

[30]  J. Heinecke Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins. , 2002, Toxicology.

[31]  Y. Shinohara,et al.  Deficiency of Myeloperoxidase Increases Infarct Volume and Nitrotyrosine Formation in Mouse Brain , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[32]  W. Parks,et al.  Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7) , 2001, The Journal of Biological Chemistry.

[33]  W. Mali,et al.  Diffusion-weighted magnetic resonance imaging in acute stroke. , 1998, Stroke.

[34]  F. Lanza Clinical manifestation of myeloperoxidase deficiency , 1998, Journal of Molecular Medicine.

[35]  M. E. Moseley,et al.  Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke , 1998, Neurology.

[36]  G. Schlaug,et al.  Enlargement of human cerebral ischemic lesion volumes measured by diffusion‐weighted magnetic resonance imaging , 1997, Annals of neurology.

[37]  C. Guarnieri,et al.  Plasma lipoperoxidative markers in ischaemic stroke suggest brain embolism. , 1997, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[38]  C. Gedye,et al.  Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. , 1997, The Biochemical journal.

[39]  Y. Shiga,et al.  Correlation Between Myeloperoxidase‐Quantified Neutrophil Accumulation and Ischemic Brain Injury in the Rat: Effects of Neutrophil Depletion , 1994, Stroke.

[40]  G Di Chiro,et al.  Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study. , 1993, Radiology.

[41]  K Minematsu,et al.  Diffusion‐weighted magnetic resonance imaging , 1992, Neurology.

[42]  Springer Basel Ag NADPH oxidases as therapeutic targets in ischemic stroke , 2012 .