Medical Image Computing and Computer-Assisted Intervention Multivariate Analysis of Structural and Diffusi Imaging in Traumatic Brain Injur 1

Rationale and Objectives. Diffusion tensor (DT) and T1 structural magnetic resonance images provide unique and complementary tools for quantifying the living brain. We leverage both modalities in a diffeomorphic normalization method that unifies analysis of clinical datasets in a consistent and inherently multivariate (MV) statistical framework. We use this technique to study MV effects of traumatic brain injury (TBI).

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