Cutaneous melanin density of Caucasians measured by spectrophotometry and risk of malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin.

Recent advances have enabled quite accurate estimation by spectrophotometry of the density of cutaneous melanin. The relation between skin cancers and this objective measure of skin phenotype is examined here. For this purpose, a population-based case-control study of subjects aged 20-59 years of northern European ancestry was conducted in Tasmania, Australia. Cases (n = 244) of cutaneous malignant melanoma during 1998-1999, and a sample of cases of basal cell carcinoma (n = 220) and squamous cell carcinoma (n = 195) of the skin were identified from cancer registrations. Controls (n = 483) were selected from a comprehensive population listing. Melanin at the upper inner arm was estimated from skin reflectance of light of 400 and 420 nm wavelengths. For melanoma, basal cell carcinoma, and squamous cell carcinoma, respectively, the odds ratios comparing the least with the highest of four melanin categories were 6.2 (95% confidence interval (CI): 2.3, 16.6), 6.3 (95% CI: 2.6, 15.1), and 4.2 (95% CI: 1.7, 10.8) for men and 1.9 (95% CI: 1.0, 3.7), 1.4 (95% CI: 0.7, 3.0), and 0.7 (95% CI: 0.3, 1.7) for women. The gender differences were not due to disparities in site of occurrence or (for melanoma) in thickness of the lesion. The authors conclude that, particularly for men, cutaneous melanin density at the upper inner arm is a strong predictor of risk of skin cancer.

[1]  T. Dwyer,et al.  Changes in self-reported skin type associated with experience of sunburning in 14-15 year old children of northern European descent , 1997, Melanoma research.

[2]  M. Tucker,et al.  The Danish case‐control study of cutaneous malignant melanoma. I. Importance of host factors , 1988, International journal of cancer.

[3]  V. Siskind,et al.  Common acquired naevi and the risk of malignant melanoma , 1985, International journal of cancer.

[4]  J. A. Bishop,et al.  Risk of cutaneous melanoma in relation to the numbers, types and sites of naevi: a case-control study. , 1996, British Journal of Cancer.

[5]  T. Fitzpatrick The validity and practicality of sun-reactive skin types I through VI. , 1988, Archives of dermatology.

[6]  D. English,et al.  Demographic characteristics, pigmentary and cutaneous risk factors for squamous cell carcinoma of the skin: A case‐control study , 1998, International journal of cancer.

[7]  J. Elwood,et al.  Malignant melanoma in relation to moles, pigmentation, and exposure to fluorescent and other lighting sources. , 1986, British Journal of Cancer.

[8]  J. Elwood Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada melanoma study , 1985 .

[9]  T. Dwyer,et al.  Melanin density and melanin type predict melanocytic naevi in 19–20 year olds of northern European ancestry , 2000, Melanoma research.

[10]  A. Hoes Case-control studies. , 1995, The Netherlands journal of medicine.

[11]  Re Waller,et al.  Principles of Exposure Measurement in Epidemiology , 1994 .

[12]  J. Cuzick,et al.  Naevi and pigmentary characteristics as risk factors for melanoma in a high‐risk population: A case‐control study in new South Wales, Australia , 1996, International journal of cancer.

[13]  T. Dwyer,et al.  The use of spectrophotometry to estimate melanin density in Caucasians. , 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[14]  T. Holford,et al.  Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis , 1996, International journal of cancer.

[15]  Ian Jackson,et al.  Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans , 1995, Nature Genetics.

[16]  B K Armstrong,et al.  Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma. , 1984, Journal of the National Cancer Institute.

[17]  Helene Z. Hill,et al.  The function of melanin or six blind people examine an elephant. , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[18]  T Dwyer,et al.  Assessment of habitual sun exposure in adolescents via questionnaire—a comparison with objective measurement using polysulphone badges , 1996, Melanoma research.