The renal metabolism of insulin

[1]  R. DeFronzo,et al.  Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. , 1983, The American journal of physiology.

[2]  W. Duckworth,et al.  Insulin metabolism and degradation. , 1981, Endocrine reviews.

[3]  B. Goldstein,et al.  Insulin degradation by insulin target cells. , 1981, Metabolism: clinical and experimental.

[4]  E. Almira,et al.  Resistance to subcutaneous and intramuscular insulin associated with deficiency of insulin-like growth factor (IGF) 2. , 1983, Metabolism: clinical and experimental.

[5]  J. Kenny,et al.  Studies on the enzymology of purified preparations of brush border from rabbit kidney. , 1973, The Biochemical journal.

[6]  W. Duckworth.  Insulin and glucagon degradation by the kidney I. Subcellular distribution under different assay conditions , 1976 .

[7]  K. Polonsky,et al.  Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction. , 1983, The Journal of clinical investigation.

[8]  R. Roth.  Bacitracin: an inhibitor of the insulin degrading activity of glutathione-insulin transhydrogenase. , 1981, Biochemical and biophysical research communications.

[9]  E. Almira,et al.  Inhibition of insulin degradation by insulin-like growth factors. , 1983, Endocrinology.

[10]  A. Katz,et al.  Insulin binding sites in various segments of the rabbit nephron. , 1983, The Journal of clinical investigation.

[11]  R. Furlanetto,et al.  Evidence that somatomedin-C is degraded by the kidney and inhibits insulin degradation. , 1977, Endocrinology.

[12]  M J Chamberlain,et al.  The renal handling of insulin. , 1967, The Journal of clinical investigation.

[13]  R. Rabkin,et al.  Removal and excretion of immunoreactive rat growth hormone by the isolated kidney. , 1981, The American journal of physiology.

[14]  K. Kurokawa,et al.  Binding and degradation of insulin by isolated renal cortical tubules. , 1980, Endocrinology.

[15]  F. Carone,et al.  Hydrolysis and transport of small peptides by the proximal tubule. , 1980, The American journal of physiology.

[16]  R. Rabkin,et al.  Renal metabolism of peptide hormones. , 1983, Mineral and electrolyte metabolism.

[17]  E. Habermann,et al.  Interactions of a protease inhibitor and other peptides with isolated brush border membranes from rat renal cortex , 1973, Naunyn-Schmiedeberg's Archives of Pharmacology.

[18]  R. Rabkin,et al.  Binding and Degradation of Insulin by Isolated Renal Brush Border Membranes , 1982, Diabetes.

[19]  I. Pastan,et al.  Formation of receptosomes from plasma membrane coated pits during endocytosis: analysis by serial sections with improved membrane labeling and preservation techniques. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Klahr,et al.  Selective uptake of intact parathyroid hormone by the liver: differences between hepatic and renal uptake. , 1976, The Journal of clinical investigation.

[21]  P. Davis,et al.  Physical Characteristics of Insulin Receptors on Renal Cell Membranes , 1978, Diabetes.

[22]  E. Lowrie,et al.  The effect of uremia upon glucose metabolism. , 1970, Archives of internal medicine.

[23]  J. Livesey,et al.  Urinary growth hormone in diabetic ketoacidosis. , 1979, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[24]  K. Kurokawa,et al.  Binding of 125I-insulin to the isolated glomeruli of rat kidney. , 1979, The Journal of clinical investigation.

[25]  H. Kuzuya,et al.  Abnormalities in circulating beta cell peptides in chronic renal failure: comparison of C-peptide, proinsulin and insulin. , 1977, The Journal of clinical endocrinology and metabolism.

[26]  D. Steiner,et al.  Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood , 1969, Nature.

[27]  W. Duckworth.  Insulin and glucagon binding and degradation by kidney cell membranes. , 1978, Endocrinology.

[28]  M. Lindheimer,et al.  Role of the kidney in hormone metabolism and its implications in clinical medicine , 1980, Klinische Wochenschrift.

[29]  S. Oparil,et al.  Differences between renal tubular processing of glucagon and insulin. , 1982, The American journal of physiology.

[30]  P. Vereerstraeten,et al.  125I-insulin metabolism in chronic renal failure treated by renal transplantation. , 1974, Kidney international.

[31]  W. Duckworth,et al.  Initial site of insulin cleavage by insulin protease. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[32]  Insulin metabolism in chronic uremia and in the anephric state: effect of the dialytic treatment. , 1975, The Journal of clinical endocrinology and metabolism.

[33]  D. Lockwood,et al.  Cellular basis of insulin resistance in chronic uremia. , 1983, The American journal of physiology.

[34]  R. Rabkin,et al.  Metabolic Characteristics of Renal Insulin Uptake , 1981, Diabetes.

[35]  R. Mahler,et al.  Metabolic effects of insulin on rat kidney after inhibiting degradation of the hormone. , 1968, Endocrinology.

[36]  PLASMA insulin. , 1957, Nutrition reviews.

[37]  A. Goldberg,et al.  Metabolic effects of exercise training in hemodialysis patients. , 1980, Kidney international.

[38]  E. Gordon,et al.  Handling of insulin by the isolated perfused rat kidney. , 1981, The American journal of physiology.

[39]  D. Papachristodoulou,et al.  Insulin Binding and Degradation by Kidney Cell Membranes of Streptozotocin-Diabetic Rats , 1982, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[40]  M. Martínez-Maldonado,et al.  Response of Dog Renal Na+, K+-ATPase to Insulin in vitro , 1978 .

[41]  K. Palmano,et al.  Studies in the renal handling of insulin in juvenile diabetics , 1976, Diabetologia.

[42]  C. Er,et al.  Insulin uptake in the renal proximal tubule , 1973 .

[43]  M. Lindheimer,et al.  Endocrine abnormalities in chronic renal failure: Pathogenetic principles and clinical implications , 1981 .

[44]  B. Vanheel,et al.  Influence of organic acids on intracellular pH. , 1983, The American journal of physiology.

[45]  R. Roth,et al.  Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes. , 1982, Endocrinology.

[46]  J. Kauffman,et al.  Insulin resistance in uremia. Characterization of insulin action, binding, and processing in isolated hepatocytes from chronic uremic rats. , 1983, The Journal of clinical investigation.

[47]  R. Rabkin,et al.  The handling of immunoreactive vasopressin by the isolated perfused rat kidney. , 1979, The Journal of clinical investigation.

[48]  K. Shii,et al.  Insulin binding and degradation in liver of fed and fasted rats: effect of antiserum to insulin-degrading enzyme on insulin binding and degradation. , 1982, Endocrinologia japonica.

[49]  E. Meezan,et al.  Binding and degradation of 125I-insulin by renal glomeruli and tubules isolated from rats , 1982, Diabetologia.

[50]  R. Rabkin,et al.  Effect of renal disease on renal uptake and excretion of insulin in man. , 1970, The New England journal of medicine.

[51]  P. T. Varandani,et al.  Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat. , 1972, Biochimica et biophysica acta.

[52]  W. Duckworth,et al.  Fate of [125I]insulin removed from the peritubular circulation of isolated perfused rat kidney. , 1982, The American journal of physiology.

[53]  A. Rubenstein,et al.  Insulin and the kidney. , 1975, Nephron.

[54]  G. Reaven,et al.  Effect of acute uremia on insulin removal by the isolated perfused rat liver and muscle. , 1978, Metabolism: clinical and experimental.

[55]  J. Malone,et al.  Renal Wastage of Insulin in Children with Diabetes Mellitus , 1976, Diabetes.

[56]  A. Katz,et al.  Insulin binding and degradation by luminal and basolateral tubular membranes from rabbit kidney. , 1982, The Journal of clinical investigation.

[57]  W. Duckworth.  Insulin and glucagon degradation by the kidney. II. Characterization of the mechanisms at neutral pH. , 1976, Biochimica et biophysica acta.

[58]  B. Brenner,et al.  Glomerular permselectivity: barrier function based on discrimination of molecular size and charge. , 1978, The American journal of physiology.

[59]  R. DeFronzo,et al.  The effects of glucose and insulin on renal electrolyte transport. , 1976, The Journal of clinical investigation.

[60]  R. Rabkin,et al.  Amino acids enhance renal tubular absorption of the los-molecular-weight proteins insulin and growth hormone. , 1982, The American journal of physiology.

[61]  W. Duckworth,et al.  Effect of prolonged uremia on insulin metabolism by isolated liver and muscle. , 1979, Kidney international.

[62]  W. Duckworth,et al.  Inhibition of insulin degradation by nonsuppressible insulin-like activity. , 1976, The Journal of clinical investigation.

[63]  A. Kitabchi,et al.  Factors influencing the handling of insulin by the isolated rat kidney. , 1978, The Journal of clinical investigation.

[64]  R. DeFronzo.  The effect of insulin on renal sodium metabolism , 1981, Diabetologia.

[65]  C. A. Taylor,et al.  Insulin degradation. XXVIII. Immunocytochemical localization of glutathione-insulin transhydrogenase in the pancreas, kidney and liver of normal and streptozotocin-diabetic rats and of lean and obese (ob/ob) mice , 1981, Diabetologia.

[66]  A. Katz,et al.  Metabolism of proinsulin, insulin, and C-peptide in the rat. , 1973, The Journal of clinical investigation.

[67]  J. H. Thomas,et al.  Insulin degradation. XXV. Glutathione-insulin transhydrogenase activity of rat liver and kidney during the development of streptozotocin-diabetes. , 1979, Biochimica et biophysica acta.

[68]  D. Papachristodoulou,et al.  The binding and degradation of 125I-labelled insulin by rat kidney brush-border membranes , 1983 .

[69]  J. Figueiredo,et al.  Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review. , 1979, Kidney international.

[70]  C. Kahn,et al.  Nonsuppressible insulin-like activity of human serum. A potent inhibitor of insulin degradation. , 1976, The Journal of clinical investigation.

[71]  A. Kitabchi,et al.  Reversible hyperinsulinuria in diabetic ketoacidosis in man. , 1981, The American journal of physiology.

[72]  J. Hare.  A novel proteinase associated with mitochondrial membranes. , 1978, Biochemical and biophysical research communications.

[73]  B. Frank,et al.  Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH. , 1972, Biochemistry.

[74]  D. Steiner,et al.  Circulating C-peptide Immunoreactivity: Studies in Normals and Diabetic Patients , 1972, Diabetes.

[75]  S. Oparil,et al.  Subcellular sites of insulin hydrolysis in renal proximal tubules. , 1984, The American journal of physiology.

[76]  M. Lindheimer,et al.  Pathogenesis of endocrine abnormalities in uremia. , 1980, Endocrine reviews.