Antifibrinolytic Treatment in Haemophilia: A Controlled Trial of Prophylaxis with Tranexamic Acid

A randomized controlled trial of the antifibrinolytic agent amino‐methylcyclohexane carboxylic acid (AMCA, Tranexamic acid) in the prophylactic treatment of haemophilia is reported. The active treatment (2 g daily) or indistinguishable inert tablets were given for 12 consecutive periods of 28 days. The effect of the active treatment was minimal and incapacity from the disease and the need for the administration of factor VIII were not reduced. It is considered that sound evidence does not exist for recommending the prophylactic use of antifibrinolytic drugs in haemophilia.

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