Cerebrospinal Fluid leak presenting with radiCulitis and delayed onset headaChe Following intratheCal pump implantation

The issue of cerebrospinal fluid (CSF) leak due to catheter-related failure persists despite new approaches to surgical techniques. There is limited literature about atypical presentations of post dural puncture headaches post intrathecal drug delivery system (IDDS) implantation. A 59-year-old woman with a past medical history of lumbar postlaminectomy syndrome, chronic pain, and lower back pain underwent an intrathecal drug delivery system implantation after exhausting other modalities for pain relief. The patient presented to the office one-month postoperatively with symptoms of lower back pain, left lower extremity radiculopathy, and lower back subcutaneous fluid collection. A dye study using catheter access port access revealed a patent intrathecal catheter with no fluid leakage or collection after injecting contrast dye through the catheter access port. A fine needle aspiration performed under ultrasound guidance revealed a clear fluid. Using laboratory evaluation, this was confirmed to be CSF using laboratory evaluation. An epidural blood patch was performed, which provided minimal radicular pain relief. Several days after, she began experiencing fronto-occipital headaches and the lumbar fluid collection reaccumulated. An intrathecal dye study again was done and showed retrograde flow from the catheter causing a lumbar fluid collection. A catheter exchange was performed resolving the CSF leak and the patient’s symptoms. Post dural puncture headaches after IDDS implantation may have an atypical presentation. Providers should ensure the intrathecal catheter is well secured and firmly anchored to prevent migration. Patient symptoms after IDDS implantation may necessitate further investigation, including: patient evaluation, confirming catheter continuity, and minimally invasive or surgical management. Complications from IDDS may be reduced with further research on equipment and implantation techniques.

[1]  Jason S. Eldrige,et al.  Treatment of Refractory Postdural Puncture Headache after Intrathecal Drug Delivery System Implantation with Epidural Blood Patch Procedures: A 20-Year Experience , 2016, Pain research and treatment.

[2]  H. Heinze,et al.  A new approach using high volume blood patch for prevention of post-dural puncture headache following intrathecal catheter pump exchange , 2015, International journal of critical illness and injury science.

[3]  J. Duggan,et al.  Treatment of post-dural puncture headache using epidural injection of fibrin sealant as an alternative to autologous epidural blood patch (case report) , 2014, Scandinavian journal of pain.

[4]  Jason S. Eldrige,et al.  Fibrin Glue to Treat Spinal Fluid Leaks Associated with Intrathecal Drug Systems , 2014, Pain practice : the official journal of World Institute of Pain.

[5]  S. Malhotra All patients with a postdural puncture headache should receive an epidural blood patch. , 2014, International journal of obstetric anesthesia.

[6]  V. Minville,et al.  Accidental dural puncture: combination of prophylactic methods to avoid post-dural puncture headache. , 2014, Annales francaises d'anesthesie et de reanimation.

[7]  Jason S. Eldrige,et al.  Post dural puncture headache following intrathecal drug delivery system placement. , 2013, Pain physician.

[8]  S. Waise,et al.  Reducing the incidence of post-dural puncture headache. , 2013, Clinical medicine.

[9]  Yong Chul Kim,et al.  An Intrathecally Located Broken Catheter Used for an Intrathecal Drug Delivery System , 2012, Journal of Korean medical science.

[10]  O. Leon-Casasola,et al.  Intrathecal pump implantation techniques , 2011 .

[11]  S. Kishida,et al.  Proinflammatory cytokines in the cerebrospinal fluid of patients with lumbar radiculopathy , 2011, European Spine Journal.

[12]  Keisuke Watanabe,et al.  Fluoroscopically guided epidural blood patch in patients with postdural puncture headache after spinal and epidural anesthesia , 2011, Journal of Anesthesia.

[13]  A. Schmitt,et al.  Meningeal (Postdural) Puncture Headache, Unintentional Dural Puncture, and the Epidural Blood Patch: A National Survey of United States Practice , 2009, Regional Anesthesia & Pain Medicine.

[14]  Howard S. Smith,et al.  Intrathecal drug delivery. , 2008, Pain physician.

[15]  Williams Ko,et al.  New Onset Lumbar Radicular Pain After Implantation of an Intrathecal Drug Delivery System: Imaging Catheter Migration , 2006, Regional Anesthesia & Pain Medicine.

[16]  P. Maeder,et al.  Intraparenchymal migration of an intrathecal catheter three years after implantation , 2005, Pain.

[17]  S. Kamran,et al.  Complications of Intrathecal Drug Delivery Systems , 2001, Neuromodulation : journal of the International Neuromodulation Society.

[18]  G. Vasdev,et al.  Postdural puncture headache: The role of prophylactic epidural blood patch , 2001, Current pain and headache reports.

[19]  K. Follett,et al.  A prospective study of catheter-related complications of intrathecal drug delivery systems. , 2000, Journal of pain and symptom management.