Microfluidic Overview of Global Health Issues Microfluidic Diagnostic Technologies for Global Public Health

The developing world does not have access to many of the best medical diagnostic technologies; they were designed for air-conditioned laboratories, refrigerated storage of chemicals, a constant supply of calibrators and reagents, stable electrical power, highly trained personnel and rapid transportation of samples. Microfluidic systems allow miniaturization and integration of complex functions, which could move sophisticated diagnostic tools out of the developed-world laboratory. These systems must be inexpensive, but also accurate, reliable, rugged and well suited to the medical and social contexts of the developing world.

[1]  Holmes Kk,et al.  The STD diagnostic network: priorities for diagnosis of STDs in resource-poor settings. , 1991 .

[2]  C. Hankins,et al.  An AIDS test that travels well. , 1993, The IDRC reports.

[3]  A. Berg,et al.  Micro Total Analysis Systems , 1995 .

[4]  M F Burritt,et al.  Point-of-care testing. , 1995, Mayo Clinic proceedings.

[5]  P. Yager,et al.  Biotechnology at low Reynolds numbers. , 1996, Biophysical journal.

[6]  Alan D. Lopez,et al.  The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020. , 1996 .

[7]  P. Yager,et al.  A planar microfabricated fluid filter , 1996 .

[8]  P. Yager,et al.  Diffusion-based extraction in a microfabricated device , 1997 .

[9]  Albert van den Berg,et al.  Micro Total Analysis Systems ’98 : Proceedings of the μTAS ’98 Workshop, held in Banff, Canada, 13–16 October 1998 , 1998 .

[10]  R. Pethig,et al.  Separation of erythrocytes and latex beads by dielectrophoretic levitation and hyperlayer field-flow fractionation. , 1998 .

[11]  Paul Yager,et al.  Applying Microfluidic Chemical Analytical Systems to Imperfect Samples , 1998 .

[12]  K. Kain,et al.  Effects of viral hemorrhagic fever inactivation methods on the performance of rapid diagnostic tests for Plasmodium falciparum. , 1998, The Journal of infectious diseases.

[13]  K. Kain,et al.  Evaluation of a rapid and inexpensive dipstick assay for the diagnosis of Plasmodium falciparum malaria. , 1999, Bulletin of the World Health Organization.

[14]  S. Shoji.  Micro Total Analysis Systems , 1999 .

[15]  Michael P. Hughes,et al.  AC electrokinetics: applications for nanotechnology , 2000 .

[16]  A. Oberoi,et al.  Evaluation of rapid kits for detection of HIV, HBsAg and HCV infections. , 2000, Indian journal of medical sciences.

[17]  Y. Huang,et al.  Cell separation by dielectrophoretic field-flow-fractionation. , 2000, Analytical chemistry.

[18]  Gabriele Gradl,et al.  MICRODEVICE FOR CELL AND PARTICLE SEPARATION USING DIELECTROPHORETIC FIELD-FLOW FRACTIONATION , 2000 .

[19]  J Taylor,et al.  Development of a multichannel microfluidic analysis system employing affinity capillary electrophoresis for immunoassay. , 2001, Analytical chemistry.

[20]  K. Kain,et al.  The performance and utility of rapid diagnostic assays for Plasmodium falciparum malaria in a field setting in the Lao People's Democratic Republic. , 2001, Annals of tropical medicine and parasitology.

[21]  J. Isaac-Renton,et al.  Comparison of a nested polymerase chain reaction--restriction fragment length polymorphism method, the PATH antigen detection method, and microscopy for the detection and identification of malaria parasites. , 2001, Canadian journal of microbiology.

[22]  P. Yager,et al.  Continuous concentration of bacteria in a microfluidic flow cell using electrokinetic techniques , 2001, Electrophoresis.

[23]  P. Abraham,et al.  Evaluation of an indigenously manufactured rapid immunochromatographic test for detection of HBsAg. , 2001, Indian journal of pathology & microbiology.

[24]  L B Reller,et al.  Practice guidelines for the management of infectious diarrhea. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[25]  P Yager,et al.  Concentration and separation of proteins in microfluidic channels on the basis of transverse IEF. , 2001, Analytical chemistry.

[26]  A. Fauci,et al.  Infectious diseases: considerations for the 21st century. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[27]  E. Hook,et al.  Preliminary Evaluation of an Immunochromatographic Strip Test for Specific Treponema pallidum Antibodies , 2002, Journal of Clinical Microbiology.

[28]  V. Melnikov,et al.  Immunochromatographic Strip Test for Rapid Detection of Diphtheria Toxin: Description and Multicenter Evaluation in Areas of Low and High Prevalence of Diphtheria , 2002, Journal of Clinical Microbiology.

[29]  M. Perkins,et al.  Diagnostic testing in the control of tuberculosis. , 2002, Bulletin of the World Health Organization.

[30]  P. Gascoyne,et al.  Particle separation by dielectrophoresis , 2002, Electrophoresis.

[31]  I. Mezić,et al.  Chaotic Mixer for Microchannels , 2002, Science.

[32]  Frederick F Becker,et al.  Microsample preparation by dielectrophoresis: isolation of malaria. , 2002, Lab on a chip.

[33]  C. Elkins,et al.  Development of a Rapid Immunodiagnostic Test for Haemophilus ducreyi , 2002, Journal of Clinical Microbiology.

[34]  M. Northrup.  Micro Total Analysis Systems 2003 , 2003 .

[35]  W Cates,et al.  Preserving fertility: an underappreciated aspect of sexual health. , 2003 .

[36]  Paul Yager,et al.  Wavelength-tunable surface plasmon resonance microscope , 2003 .

[37]  C. Tiemann,et al.  Ultra-rapid detection of Chlamydia trachomatis by real-time PCR in the LightCycler using SYBR green technology or 5'-nuclease probes. , 2003, Clinical laboratory.

[38]  Robert E Black,et al.  Where and why are 10 million children dying every year? , 2003, The Lancet.

[39]  Paul Yager,et al.  Nonlinear decrease of background fluorescence in polymer thin-films - a survey of materials and how they can complicate fluorescence detection in microTAS. , 2003, Lab on a chip.

[40]  Margaret-Mary G. Wilson,et al.  Sexually transmitted diseases. , 2003, Clinics in geriatric medicine.

[41]  Guilbert Jj.  The world health report 2002 - reducing risks, promoting healthy life. , 2003 .

[42]  Paul Yager,et al.  Characterization of a wavelength-tunable surface plasmon resonance microscope , 2004 .

[43]  A. Fauci,et al.  The challenge of emerging and re-emerging infectious diseases , 2004, Nature.

[44]  J. Sobel,et al.  A multistate outbreak of Escherichia coli O157:H7 infection linked to consumption of beef tacos at a fast-food restaurant chain. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[45]  I. Buchanan,et al.  Development of a rapid enzyme immunoassay for the detection of retinol-binding protein. , 2004, The American journal of clinical nutrition.

[46]  Paul Yager,et al.  Controlled microfluidic reconstitution of functional protein from an anhydrous storage depot. , 2004, Lab on a chip.

[47]  M. Mwasekaga,et al.  Tuberculosis serodiagnosis in a predominantly HIV-infected population of hospitalized patients with cough, Botswana, 2002. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[48]  Piia von Lode,et al.  Point-of-care immunotesting: approaching the analytical performance of central laboratory methods. , 2005, Clinical biochemistry.

[49]  R. Peeling,et al.  Detection of gonococcal infection : pros and cons of a rapid test. , 2005, Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology.

[50]  Andreas Manz,et al.  Single-molecule fluorescence detection in microfluidic channels—the Holy Grail in μTAS? , 2005, Analytical and bioanalytical chemistry.

[51]  A. V. D. van den Brule,et al.  Evaluation of Conventional and Real-Time PCR Assays Using Two Targets for Confirmation of Results of the COBAS AMPLICOR Chlamydia trachomatis/Neisseria gonorrhoeae Test for Detection of Neisseria gonorrhoeae in Clinical Samples , 2005, Journal of Clinical Microbiology.

[52]  Piia von Lode,et al.  Point-of-care immunotesting: approaching the analytical performance of central laboratory methods. , 2005 .

[53]  G. Becker,et al.  The Quantity and Quality of Life and the Evolution of World Inequality , 2003, The American economic review.

[54]  Mehmet Toner,et al.  Blood-on-a-chip. , 2005, Annual review of biomedical engineering.

[55]  John T McDevitt,et al.  A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings , 2005, PLoS medicine.

[56]  S. Lehmann,et al.  Protein biochip systems for the clinical laboratory , 2005, Clinical chemistry and laboratory medicine.

[57]  S. Ramachandran,et al.  Fully integrated multiplexed lab-on-a-card assay for enteric pathogens , 2006, SPIE MOEMS-MEMS.

[58]  A. Mcguire,et al.  More money for medical research , 2006, BMJ : British Medical Journal.

[59]  C. Carne,et al.  The superiority of polymerase chain reaction over an amplified enzyme immunoassay for the detection of genital chlamydial infections , 2006, Sexually Transmitted Infections.

[60]  Paul Yager,et al.  Compact, high performance surface plasmon resonance imaging system. , 2007, Biosensors & bioelectronics.

[61]  Steffen Flessa,et al.  Investing in health , 2007, Journal of Public Health.

[62]  C. Price.  Regular review Point of care testing , 2022 .