Efecto de la ingesta de leche fermentada con Lactobacillus casei DN-114 001 sobre la flora intestinal

Objetivo Estudiar las caracteristicas de la flora microbiana intestinal de ninos que recibieron en su dieta leche fermentada con Lactobacillus casei y Streptococcus termophilus y su repercusion en los valores de inmunoglobulinas secretoras. Material y metodos Estudio experimental aleatorizado, prospectivo, con 2 grupos paralelos. Se incluyeron un total de 35 ninos (18 en el grupo experimental y 17 en el grupo control), con una edad media de 2 anos (DE: 0,6 anos; rango: 1-3 anos). El grupo experimental recibio en su dieta leche fermentada (500 ml/dia) con L. casei y S. termophilus durante 6 semanas y leche de vaca normal estandar durante 6 semanas mas. El grupo control recibio leche de vaca normal estandar (500 ml/dia) a lo largo de todo el estudio. Se evaluaron los valores de IgA secretora en saliva del grupo experimental al inicio y a las 6 semanas del estudio. Se recogieron heces para el estudio de la flora intestinal a las 0, 6 y 12 semanas en ambos grupos. Resultados Se observo un aumento estadisticamente significativo (p = 0,0063) de un valor medio basal de 2,5 mg/dl al inicio hasta una media de 3,4 mg/dl a las 6 semanas. Asi mismo, se observo un descenso de la flora aerobica gramnegativa a la semana 6 en comparacion con el grupo control (p = 0,0203). La proporcion de ninos en los que se les aislo Lactobacillus spp. en la flora intestinal fue superior en el grupo experimental a partir de la semana 6 y llegando a ser estadisticamente significativa (p = 0,028) a las 12 semanas. Conclusion El presente estudio aporta evidencia sobre la supervivencia de L. casei en el tracto intestinal y su efecto inmunoestimulante en un incremento significativo del la IgA secretora.

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