Beyond conventional immune-checkpoint inhibition — novel immunotherapies for renal cell carcinoma
暂无分享,去创建一个
[1] Steven L. Chang,et al. Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma , 2021, Nature Communications.
[2] T. Choueiri,et al. A Randomized Phase II Study of AGS-16C3F Versus Axitinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma. , 2020, The Oncologist.
[3] W. Kaelin,et al. Targeting the HIF2–VEGF axis in renal cell carcinoma , 2020, Nature Medicine.
[4] C. Porta,et al. Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial , 2020, Journal for ImmunoTherapy of Cancer.
[5] B. Escudier,et al. Immunomodulatory Roles of VEGF Pathway Inhibitors in Renal Cell Carcinoma , 2020, Drugs.
[6] M. Atkins,et al. Salvage Ipilimumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma After Prior Immune Checkpoint Inhibitors. , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] Loise M. Francisco,et al. The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection. , 2020, Cell reports.
[8] T. Choueiri,et al. Evaluation of the Safety and Efficacy of Immunotherapy Rechallenge in Patients With Renal Cell Carcinoma. , 2020, JAMA oncology.
[9] Ashton C. Berger,et al. Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma , 2020, Nature Medicine.
[10] T. Choueiri,et al. Safety and efficacy of CDX-014, an antibody-drug conjugate directed against T cell immunoglobulin mucin-1 in advanced renal cell carcinoma , 2020, Investigational New Drugs.
[11] T. Powles,et al. Pembrolizumab plus axitinib versus sunitinib as first-line therapy for advanced renal cell carcinoma (RCC): Updated analysis of KEYNOTE-426. , 2020, Journal of Clinical Oncology.
[12] J. Larkin,et al. Long-term follow up of lifileucel (LN-144) cryopreserved autologous tumor infiltrating lymphocyte therapy in patients with advanced melanoma progressed on multiple prior therapies. , 2020 .
[13] Robert W. Hsieh,et al. Primary analysis of a randomized, double-blind, phase II study of the anti-TIGIT antibody tiragolumab (tira) plus atezolizumab (atezo) versus placebo plus atezo as first-line (1L) treatment in patients with PD-L1-selected NSCLC (CITYSCAPE). , 2020 .
[14] P. Hegde,et al. High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade , 2020, Nature Medicine.
[15] Hongyu Zhao,et al. Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors , 2020, Nature Medicine.
[16] T. Choueiri,et al. IL-8 and cancer prognosis on immunotherapy , 2020, Nature Medicine.
[17] P. Sears. epitopes , 2020, Catalysis from A to Z.
[18] C. Mackall,et al. The Emerging Landscape of Immune Cell Therapies , 2020, Cell.
[19] S. Buti,et al. Nivolumab (NIVO) in combination with stereotactic body radiotherapy (SBRT) in pretreated patients (pts) with metastatic renal cell carcinoma (mRCC): First results of phase II NIVES study. , 2020 .
[20] J. Larkin,et al. Depth of response (DepOR) analysis and correlation with clinical outcomes from JAVELIN Renal 101. , 2020 .
[21] Sierra M. Barone,et al. Targeting metabolic dysregulation of T cells in kidney cancer. , 2020 .
[22] D. Song,et al. Combination of dual immune checkpoint inhibition (ICI) with stereotactic radiation (SBRT) in metastatic renal cell carcinoma (mRCC) (RADVAX RCC). , 2020 .
[23] W. Lowrance,et al. Results of the ADAPT Phase 3 Study of Rocapuldencel-T in Combination with Sunitinib as First-Line Therapy in Patients with Metastatic Renal Cell Carcinoma , 2020, Clinical Cancer Research.
[24] B. Routy,et al. New pathways in immune stimulation: targeting OX40 , 2020, ESMO Open.
[25] M. Loustau. First CAR-T cell immunotherapy against HLA-G: Targeting a unique ICP and TAA , 2019 .
[26] A. Kamphorst,et al. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells , 2019, Nature.
[27] N. Raje,et al. Anti-BCMA CAR T-cell therapy in multiple myeloma: can we do better? , 2019, Leukemia.
[28] T. Choueiri,et al. Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer. , 2019, Cancer discovery.
[29] R. Zagożdżon,et al. Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer , 2019, Cancers.
[30] N. Hacohen,et al. A large peptidome dataset improves HLA class I epitope prediction across most of the human population , 2019, Nature Biotechnology.
[31] E. Jonasch,et al. A first-in-human phase I/II trial of the oral HIF-2a inhibitor PT2977 in patients with advanced RCC , 2019, Annals of Oncology.
[32] T. Powles,et al. Association between depth of response and overall survival: Exploratory analysis in patients with previously untreated advanced renal cell carcinoma (aRCC) in CheckMate 214 , 2019, Annals of Oncology.
[33] T. Ho,et al. Safety and efficacy of the oral CXCR4 inhibitor X4P-001 + axitinib in advanced renal cell carcinoma patients: An analysis of subgroup responses by prior treatment , 2019, Annals of Oncology.
[34] T. Powles,et al. Treatment-free survival, with and without toxicity, as a novel outcome applied to immuno-oncology agents in advanced renal cell carcinoma , 2019, Annals of Oncology.
[35] R. Motzer,et al. Efficacy and biomarker analysis of patients (pts) with advanced renal cell carcinoma (aRCC) with sarcomatoid histology (sRCC): Subgroup analysis from the phase III JAVELIN renal 101 trial of first-line avelumab plus axitinib (A + Ax) vs sunitinib (S) , 2019, Annals of Oncology.
[36] Guo Ci Teo,et al. Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma , 2019, Cell.
[37] G. Curigliano,et al. Phase (Ph) II study of MBG453 + spartalizumab in patients (pts) with non-small cell lung cancer (NSCLC) and melanoma pretreated with anti–PD-1/L1 therapy , 2019, Annals of Oncology.
[38] Y. Vugmeyster,et al. Phase Ib, open-label, dose-escalation study of M9241 (NHS-IL12) plus avelumab in patients (pts) with advanced solid tumours , 2019, Annals of Oncology.
[39] Junnian Zheng,et al. CAIX-specific CAR-T Cells and Sunitinib Show Synergistic Effects Against Metastatic Renal Cancer Models , 2019, Journal of immunotherapy.
[40] W. Sellers,et al. Metabolomic adaptations and correlates of survival to immune checkpoint blockade , 2019, Nature Communications.
[41] J. Wolchok,et al. Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition—A Pooled Analysis of Patients With Advanced Melanoma , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[42] H. Rammensee,et al. PD-1 and LAG-3 Dominate Checkpoint Receptor–Mediated T-cell Inhibition in Renal Cell Carcinoma , 2019, Cancer Immunology Research.
[43] S. Elledge,et al. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes , 2019, Cell.
[44] James R. Anderson,et al. Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study. , 2019, The Lancet. Oncology.
[45] N. Hacohen,et al. PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance , 2019, Nature Immunology.
[46] N. Vélez de Mendizábal,et al. A phase Ia/Ib study of an anti-TIM-3 antibody (LY3321367) monotherapy or in combination with an anti-PD-L1 antibody (LY3300054): Interim safety, efficacy, and pharmacokinetic findings in advanced cancers. , 2019, Journal of Clinical Oncology.
[47] C. Porta,et al. Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial , 2019, The Lancet.
[48] T. Powles,et al. Pembrolizumab (pembro) plus axitinib (axi) versus sunitinib as first-line therapy for metastatic renal cell carcinoma (mRCC): Outcomes in the combined IMDC intermediate/poor risk and sarcomatoid subgroups of the phase 3 KEYNOTE-426 study. , 2019, Journal of Clinical Oncology.
[49] R. Motzer,et al. CheckMate 214 post-hoc analyses of nivolumab plus ipilimumab or sunitinib in IMDC intermediate/poor-risk patients with previously untreated advanced renal cell carcinoma with sarcomatoid features. , 2019, Journal of Clinical Oncology.
[50] C. Porta,et al. Atezolizumab (atezo) + bevacizumab (bev) versus sunitinib (sun) in pts with untreated metastatic renal cell carcinoma (mRCC) and sarcomatoid (sarc) histology: IMmotion151 subgroup analysis. , 2019, Journal of Clinical Oncology.
[51] J. Soria,et al. Antibody–Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index , 2019, Clinical Cancer Research.
[52] David C. Smith,et al. A phase 1 trial of SGN‐CD70A in patients with CD70‐positive, metastatic renal cell carcinoma , 2019, Cancer.
[53] Catherine J. Wu,et al. Cancer Vaccines: Steering T Cells Down the Right Path to Eradicate Tumors. , 2019, Cancer discovery.
[54] T. Powles,et al. Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal‐Cell Carcinoma , 2019, The New England journal of medicine.
[55] R. Motzer,et al. Avelumab plus Axitinib versus Sunitinib for Advanced Renal‐Cell Carcinoma , 2019, The New England journal of medicine.
[56] E. Moon,et al. CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment , 2019, Front. Immunol..
[57] P. Catalano,et al. irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial , 2019, Clinical Cancer Research.
[58] C. Brennan,et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types , 2019, Nature Genetics.
[59] J. Castle,et al. Actively personalized vaccination trial for newly diagnosed glioblastoma , 2018, Nature.
[60] Alyssa R. Richman,et al. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial , 2018, Nature.
[61] K. Grønbæk,et al. Human endogenous retroviruses and their implication for immunotherapeutics of cancer. , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[62] K. Livak,et al. A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens. , 2018, Blood.
[63] J. Luke,et al. Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis , 2018, Clinical Cancer Research.
[64] S. Signoretti,et al. Renal Cell Carcinoma in the Era of Precision Medicine: From Molecular Pathology to Tissue-Based Biomarkers. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[65] T. Choueiri,et al. Evolving Systemic Treatment Landscape for Patients With Advanced Renal Cell Carcinoma. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[66] N. Rioux-Leclercq,et al. Non-Clear Cell Renal Cell Carcinomas: From Shadow to Light. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[67] Sara R. Selitsky,et al. Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma , 2018, The Journal of clinical investigation.
[68] A. Tolcher,et al. Safety, tolerability, and pharmacokinetics of the OX40 agonist ABBV-368 in patients with advanced solid tumors. , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[69] J. Schlom,et al. First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors , 2018, Clinical Cancer Research.
[70] L. Emens,et al. Targeting adenosine for cancer immunotherapy , 2018, Journal of Immunotherapy for Cancer.
[71] Leonard D. Goldstein,et al. An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors. , 2018, Cancer discovery.
[72] J. Larkin,et al. NKTR-214 (CD122-biased agonist) plus nivolumab in patients with advanced solid tumors: Preliminary phase 1/2 results of PIVOT. , 2018 .
[73] J. Reeves,et al. Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma , 2018, Nature Medicine.
[74] Molly F. Thomas,et al. Diagnosis and Management of Hepatitis in Patients on Checkpoint Blockade , 2018, The oncologist.
[75] Tyler J. Reich,et al. Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells , 2018, Nature.
[76] R. Motzer,et al. Phase I Trials of Anti-ENPP3 Antibody–Drug Conjugates in Advanced Refractory Renal Cell Carcinomas , 2018, Clinical Cancer Research.
[77] J. Wolchok,et al. Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. , 2018, Cancer cell.
[78] Paul T. Spellman,et al. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma , 2018, Cell reports.
[79] Steven J. M. Jones,et al. The Immune Landscape of Cancer , 2018, Immunity.
[80] Bohuslav Melichar,et al. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal‐Cell Carcinoma , 2018, The New England journal of medicine.
[81] M. Kunitski,et al. Double-slit photoelectron interference in strong-field ionization of the neon dimer , 2018, Nature Communications.
[82] Mark W. Ball,et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma , 2018, Science.
[83] R. Kerbel,et al. Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa , 2018, Nature Reviews Clinical Oncology.
[84] R. Bourgon,et al. TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells , 2018, Nature.
[85] B. Seliger,et al. T-cell Responses in the Microenvironment of Primary Renal Cell Carcinoma—Implications for Adoptive Cell Therapy , 2018, Cancer Immunology Research.
[86] I. Melero,et al. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies. , 2018, Blood.
[87] E. Jaffee,et al. Tumor Mutational Burden and Response Rate to PD-1 Inhibition. , 2017, The New England journal of medicine.
[88] Peter K. Sorger,et al. Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy , 2017, Cell.
[89] H. Rammensee,et al. Results of a Phase 1/2 Study in Metastatic Renal Cell Carcinoma Patients Treated with a Patient-specific Adjuvant Multi-peptide Vaccine after Resection of Metastases. , 2017, European urology focus.
[90] J. Lee,et al. 1141PDCA-170, a first in class oral small molecule dual inhibitor of immune checkpoints PD-L1 and VISTA, demonstrates tumor growth inhibition in pre-clinical models and promotes T cell activation in Phase 1 study , 2017 .
[91] Nicolai J. Birkbak,et al. Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis. , 2017, The Lancet. Oncology.
[92] Laurence Zitvogel,et al. The immune contexture in cancer prognosis and treatment , 2017, Nature Reviews Clinical Oncology.
[93] J. Utikal,et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer , 2017, Nature.
[94] Charles H. Yoon,et al. An immunogenic personal neoantigen vaccine for patients with melanoma , 2017, Nature.
[95] A. Belldegrun,et al. Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma: The ARISER Randomized Clinical Trial , 2017, JAMA oncology.
[96] E. Schmidt,et al. Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors , 2017, Clinical Cancer Research.
[97] W. Rathmell,et al. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. , 2017, JCI insight.
[98] L. Garraway,et al. Metabolomic correlates of response in nivolumab-treated renal cell carcinoma and melanoma patients. , 2017 .
[99] David C. Smith,et al. Epacadostat plus pembrolizumab in patients with advanced RCC: Preliminary phase I/II results from ECHO-202/KEYNOTE-037. , 2017 .
[100] A. El-Khoueiry,et al. The relationship of pharmacodynamics (PD) and pharmacokinetics (PK) to clinical outcomes in a phase I study of OX40 agonistic monoclonal antibody (mAb) PF-04518600 (PF-8600). , 2017 .
[101] Michael B. Stadler,et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma , 2017, Cell.
[102] D. Allard,et al. Targeting A2 adenosine receptors in cancer , 2017, Immunology and cell biology.
[103] Guangming Zhou,et al. Ecto-5′-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells , 2017, Oncotarget.
[104] A. Badawy. Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects , 2017, International journal of tryptophan research : IJTR.
[105] E. Tartour,et al. Tim-3 Expression on Tumor-Infiltrating PD-1+CD8+ T Cells Correlates with Poor Clinical Outcome in Renal Cell Carcinoma. , 2017, Cancer research.
[106] I. Diaconu,et al. Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.
[107] Catherine J. Wu,et al. Antigen Discovery and Therapeutic Targeting in Hematologic Malignancies. , 2017, Cancer journal.
[108] S. Robson,et al. The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets , 2017, Immunological reviews.
[109] P. Validire,et al. Tumor-Infiltrating and Peripheral Blood T-cell Immunophenotypes Predict Early Relapse in Localized Clear Cell Renal Cell Carcinoma , 2017, Clinical Cancer Research.
[110] Ludmila V. Danilova,et al. Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures , 2016, Genome Biology.
[111] J. Yang,et al. Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers , 2016, Clinical Cancer Research.
[112] B. Rini,et al. IMA901, a multipeptide cancer vaccine, plus sunitinib versus sunitinib alone, as first-line therapy for advanced or metastatic renal cell carcinoma (IMPRINT): a multicentre, open-label, randomised, controlled, phase 3 trial. , 2016, The Lancet. Oncology.
[113] R. Ferris,et al. Phase 1 study of MEDI0562, a humanized OX40 agonist monoclonal antibody (mAb), in adult patients (pts) with advanced solid tumors , 2016 .
[114] S. Sleijfer,et al. Treatment of metastatic renal cell carcinoma (mRCC) with CAIX CAR-engineered T-cells-a completed study overview. , 2016, Biochemical Society transactions.
[115] W. Oyen,et al. Phase 2 Study of Lutetium 177-Labeled Anti-Carbonic Anhydrase IX Monoclonal Antibody Girentuximab in Patients with Advanced Renal Cell Carcinoma. , 2016, European urology.
[116] G. Freeman,et al. Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model , 2016, Oncotarget.
[117] P. Hegde,et al. The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition , 2016, Clinical Cancer Research.
[118] Zhenjie Wu,et al. Tim-3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma , 2016, World Journal of Urology.
[119] Kole T. Roybal,et al. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits , 2016, Cell.
[120] W. Linehan,et al. Detection of an Immunogenic HERV-E Envelope with Selective Expression in Clear Cell Kidney Cancer. , 2016, Cancer research.
[121] M. Addepalli,et al. NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models , 2016, Clinical Cancer Research.
[122] Nikolaos Diamantis,et al. Antibody-drug conjugates—an emerging class of cancer treatment , 2016, British Journal of Cancer.
[123] T. Eleftheriadis,et al. Indoleamine 2,3‐dioxygenase depletes tryptophan, activates general control non‐derepressible 2 kinase and down‐regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells , 2015, Immunology.
[124] David L Porter,et al. CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. , 2015, Blood.
[125] N. Vigneron. Human Tumor Antigens and Cancer Immunotherapy , 2015, BioMed research international.
[126] T. Choueiri,et al. Depth of remission is a prognostic factor for survival in patients with metastatic renal cell carcinoma. , 2015, European urology.
[127] Irene Georgakoudi,et al. From Shadow to Light , 2015, Surgical innovation.
[128] G. Freeman,et al. Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer , 2015, Clinical Cancer Research.
[129] N. Hacohen,et al. Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity , 2015, Cell.
[130] R. Figlin,et al. The High-Dose Aldesleukin “Select” Trial: A Trial to Prospectively Validate Predictive Models of Response to Treatment in Patients with Metastatic Renal Cell Carcinoma , 2014, Clinical Cancer Research.
[131] O. Hakenberg,et al. Spontaneous regression of renal cell carcinoma: Reality or myth? , 2014 .
[132] A. Mayer-Mokler,et al. IMA901: A multi-peptide cancer vaccine for treatment of renal cell cancer , 2014, Human vaccines & immunotherapeutics.
[133] B. Becher,et al. New insights into IL-12-mediated tumor suppression , 2014, Cell Death and Differentiation.
[134] J. Schlom,et al. The immunocytokine NHS-IL12 as a potential cancer therapeutic , 2014, Oncotarget.
[135] B. Fox,et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. , 2013, Cancer research.
[136] Adam Bagg,et al. Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma. , 2013, Blood.
[137] I. Mellman,et al. Oncology meets immunology: the cancer-immunity cycle. , 2013, Immunity.
[138] The Cancer Genome Atlas Research Network. COMPREHENSIVE MOLECULAR CHARACTERIZATION OF CLEAR CELL RENAL CELL CARCINOMA , 2013, Nature.
[139] S. Poletajew,et al. Spontaneous regression of renal cell carcinoma , 2013, Contemporary oncology.
[140] S. Sleijfer,et al. Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.
[141] Laurence Zitvogel,et al. Immunogenic cell death in cancer therapy. , 2013, Annual review of immunology.
[142] K. Yamakado,et al. Limited expression of cancer-testis antigens in renal cell carcinoma patients. , 2013, Molecular and clinical oncology.
[143] Tongguang Wang,et al. Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy , 2013, Journal of immunotherapy.
[144] Hiroaki Tanaka,et al. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival , 2012, Nature Medicine.
[145] I. Melero,et al. A Phase I Pharmacologic Study of Necitumumab (imc-11f8), a Fully Human Igg1 Monoclonal Antibody the Hif-1␣ Hypoxia Response in Tumor-infi Ltrating T Lymphocytes Induces Functional Cd137 (4-1bb) for Immunotherapy , 2022 .
[146] S. Steinberg,et al. Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy , 2011, Clinical Cancer Research.
[147] J. Tostain,et al. Carbonic anhydrase 9 in clear cell renal cell carcinoma: a marker for diagnosis, prognosis and treatment. , 2010, European journal of cancer.
[148] H. Weiner,et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells , 2010, Nature Immunology.
[149] B. Escudier,et al. A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma , 2009, Clinical Cancer Research.
[150] M. Lerman,et al. Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? , 2009, Biochimica et biophysica acta.
[151] S. Steinberg,et al. High‐dose interleukin‐2 for the treatment of metastatic renal cell carcinoma , 2008, Cancer.
[152] J Philip McCoy,et al. Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. , 2008, The Journal of clinical investigation.
[153] Jeffrey W. Clark,et al. Targeted Agents: The Rules of Combination , 2007, Clinical Cancer Research.
[154] S. Sleijfer,et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[155] F. Peale,et al. Expression of vascular endothelial growth factor, hypoxia inducible factor 1α, and carbonic anhydrase IX in human tumours , 2004, Journal of Clinical Pathology.
[156] S. Buisson,et al. MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223). , 2003, Blood.
[157] D. Vignali,et al. The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells , 2003, European journal of immunology.
[158] M. Raffeld,et al. Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes , 2002, Science.
[159] K. Toyka,et al. Therapies , 2002, Journal of the Neurological Sciences.
[160] W. Linehan,et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. , 2000, The New England journal of medicine.
[161] R. Figlin,et al. Multicenter, randomized, phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[162] R. Figlin,et al. Treatment of metastatic renal cell carcinoma with nephrectomy, interleukin-2 and cytokine-primed or CD8(+) selected tumor infiltrating lymphocytes from primary tumor. , 1997, The Journal of urology.
[163] W. Kaelin,et al. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[164] A. Chang,et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. , 1985, The New England journal of medicine.
[165] T. Choueiri,et al. Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer , 2019 .
[166] S. Signoretti,et al. Chimeric antigen receptor T cells secreting anti-PD-L 1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model , 2016 .
[167] G. Riethmüller,et al. Monoclonal antibodies in cancer therapy , 2004, Springer Seminars in Immunopathology.
[168] T. Fleming,et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.