Method for Regulating Oscillatory Dynamic Behavior in a Zymomonas mobiliz Continuous Fermentation Process

Periodically oscillating concentrations of product, biomass, and substrate have been observed in a continuous fermentations process with Zymomonas mobiliz both in experiments and simulations. This paper describes the characteristics of oscillatory phenomena based on Hopf bifurcation analysis and proposes a method to regulate the oscillatory dynamic behavior. In this method, these dynamic behaviors of oscillations in concentrations of product, biomass, and substrate were simulated, the relationship between amplitude/period and operational condition was modeled. This model could be used as a guide to adjust the operating conditions to attenuate unfavorable oscillations and mitigate corresponding operability problems when the oscillation itself is unavoidable.

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