Proapoptotic Nitric Oxide Production in Amyloid β Protein‐Treated Cerebral Microvascular Endothelial Cells

Objective: The objective of this study was to investigate the effects of amyloid β protein (Aβ) on cerebral microvascular endothelium, and their possible involvement in Aβ‐induced apoptosis in the neighboring cells.

[1]  M. Hecht,et al.  Sequence Determinants of Enhanced Amyloidogenicity of Alzheimer Aβ42 Peptide Relative to Aβ40* , 2005, Journal of Biological Chemistry.

[2]  Irene Otte-Höller,et al.  Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. , 2005, The American journal of pathology.

[3]  J. Xu,et al.  Amyloid‐β peptide enhances tumor necrosis factor‐α‐induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes , 2005 .

[4]  Q. Feng,et al.  Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure. , 2005, Pharmacology & therapeutics.

[5]  M. Nieto,et al.  Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice , 2004, Neuroscience.

[6]  B. MacVicar,et al.  Calcium transients in astrocyte endfeet cause cerebrovascular constrictions , 2004, Nature.

[7]  Y. Nose,et al.  Constitutive nitric oxide production in bovine aortic and brain microvascular endothelial cells: a comparative study , 2004, The Journal of physiology.

[8]  K. Jellinger,et al.  Only cerebral capillary amyloid angiopathy correlates with Alzheimer pathology—a pilot study , 2004, Acta Neuropathologica.

[9]  Brigitte Wildemann,et al.  Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with β-amyloid 1–42 in vitro , 2002, Neuroscience Letters.

[10]  K. Masuda,et al.  Tumor cell apoptosis by irradiation-induced nitric oxide production in vascular endothelium. , 2002, Cancer research.

[11]  T. Klockgether,et al.  Neuronal and Glial Coexpression of Argininosuccinate Synthetase and Inducible Nitric Oxide Synthase in Alzheimer Disease , 2001, Journal of neuropathology and experimental neurology.

[12]  J. Rhodin,et al.  A Vascular Connection to Alzheimer's Disease , 2001, Microcirculation.

[13]  J. C. Torre,et al.  Evidence that Alzheimer’s disease is a microvascular disorder: the role of constitutive nitric oxide , 2000, Brain Research Reviews.

[14]  S. Oyadomari,et al.  Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. , 2000, Brain research. Molecular brain research.

[15]  G. Brown,et al.  Nitric‐Oxide‐Induced Necrosis and Apoptosis in PC12 Cells Mediated by Mitochondria , 2000, Journal of neurochemistry.

[16]  N. Shibata,et al.  iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis , 2000, Neuroscience Letters.

[17]  T. Bayer,et al.  Subacute NO generation induced by Alzheimer's β‐amyloid in the living brain: reversal by inhibition of the inducible NO synthase , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  L. V. Van Eldik,et al.  β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism* , 2000, The Journal of Biological Chemistry.

[19]  D. Bredt.  Endogenous nitric oxide synthesis: biological functions and pathophysiology. , 1999, Free radical research.

[20]  R. Floyd.  Antioxidants, oxidative stress, and degenerative neurological disorders. , 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[21]  D. Sawyer,et al.  Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation. , 1999, Circulation research.

[22]  Zhuo Zhang,et al.  Critical role of GSH in silica-induced oxidative stress, cytotoxicity, and genotoxicity in alveolar macrophages. , 1999, American journal of physiology. Lung cellular and molecular physiology.

[23]  S. Lipton.  Neuronal protection and destruction by NO , 1999, Cell Death and Differentiation.

[24]  B. Mayer,et al.  Enzymatic function of nitric oxide synthases. , 1999, Cardiovascular research.

[25]  M. Weller,et al.  Induction of Nitric Oxide Synthase and Nitric Oxide‐Mediated Apoptosis in Neuronal PC12 Cells After Stimulation with Tumor Necrosis FActor‐α/Lipopolysaccharide , 1998 .

[26]  T. Bilfinger,et al.  Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. , 1998, Journal of cardiovascular pharmacology.

[27]  S. Kawahara,et al.  Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins. , 1998, Analytical chemistry.

[28]  S. Kashiwagi,et al.  Effects of Acute Glucose Overload on Histamine H2 Receptor–Mediated Ca2+ Mobilization in Bovine Cerebral Endothelial Cells , 1998, Diabetes.

[29]  M. N. Wallace,et al.  Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques , 1997, Experimental Neurology.

[30]  D. Ferrari,et al.  Activation of microglial cells by β-amyloid protein and interferon-γ , 1995, Nature.

[31]  J. Miller,et al.  Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. , 1993, Archives of neurology.

[32]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[33]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[34]  U. Förstermann,et al.  Inducible Nitric Oxide Synthase , 2008 .

[35]  P. Amouyel,et al.  Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study. , 2003, Human molecular genetics.

[36]  M. C. Angulo,et al.  Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation , 2003, Nature Neuroscience.

[37]  B. Zlokovic,et al.  The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. , 2002, Journal of Alzheimer's disease : JAD.

[38]  T. Koyama,et al.  Impairment of endothelial nitric oxide production by acute glucose overload. , 2001, American journal of physiology. Endocrinology and metabolism.

[39]  P. Weigel,et al.  Short Communication Microvessels from Alzheimer’s Disease Brains Kill Neurons in Vitro , 1999 .