Reversible inactivation of subcortical sites by drug injection

Reversible inactivation of subcortical targets by means of drug injections has been a powerful tool for revealing the contributions of discrete brain structures to behavior and the functional organization of the brain. This paper is intended to provide practical advice on this approach, including the choice of drug, means of delivering drugs, strategies for evaluating the action of injected drugs, and the application of this method to experiments with awake animals.

[1]  C. Faingold,et al.  Stimulation or blockade of the dorsal nucleus of the lateral lemniscus alters binaural and tonic inhibition in contralateral inferior colliculus neurons , 1993, Hearing Research.

[2]  J G Malpeli,et al.  Cat area 17. IV. Two types of corticotectal cells defined by controlling geniculate inputs. , 1986, Journal of neurophysiology.

[3]  J. Maunsell,et al.  Magnocellular and parvocellular contributions to the responses of neurons in macaque striate cortex , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[4]  P. Schiller,et al.  Response properties of single cells in monkey striate cortex during reversible inactivation of individual lateral geniculate laminae. , 1981, Journal of neurophysiology.

[5]  Peter H. Schiller,et al.  A method of reversible inactivation of small regions of brain tissue , 1979, Journal of Neuroscience Methods.

[6]  Observations on injections of drugs into the brain substance. , 1959 .

[7]  J. Malpeli,et al.  Thalamic control of cat lateral suprasylvian visual area: Relation to patchy association projections from area 18 , 1998, Visual Neuroscience.

[8]  D. Sparks,et al.  Population coding of saccadic eye movements by neurons in the superior colliculus , 1988, Nature.

[9]  G. Lynch,et al.  A microdrive for use with glass or metal microelectrodes in recording from freely-moving rats. , 1979, Electroencephalography and clinical neurophysiology.

[10]  R. Olsen,et al.  GABAA receptor channels. , 1994, Annual review of neuroscience.

[11]  J. Malpeli,et al.  The representation of the visual field in the lateral geniculate nucleus of Macaca mulatta , 1975, The Journal of comparative neurology.

[12]  P. Schiller,et al.  Composition of geniculostriate input ot superior colliculus of the rhesus monkey. , 1979, Journal of neurophysiology.

[13]  Area 18 corticotectal cells: response properties and identification of sustaining geniculate inputs. , 1991, Journal of neurophysiology.

[14]  A new method of mounting and directing chronically implanted microdrives , 1992, Journal of Neuroscience Methods.

[15]  M. Mignard,et al.  Paths of information flow through visual cortex. , 1991, Science.

[16]  John H. Martin.  Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat , 1991, Neuroscience Letters.

[17]  T. Babb,et al.  Procaine-induced seizures in epileptic monkeys with bilateral hippocampal foci. , 1979, Electroencephalography and clinical neurophysiology.

[18]  T. Narahashi.  Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes. , 1972, Federation proceedings.

[19]  J. Malpeli,et al.  Cobalt destroys neurons without destroying fibers of passage in the lateral geniculate nucleus of the cat , 1982, Neuroscience Letters.

[20]  R. Wurtz,et al.  Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculline in monkey superior colliculus. , 1985, Journal of neurophysiology.

[21]  K. Sanderson,et al.  The projection of the visual field to the lateral geniculate and medial interlaminar nuclei in the cat , 1971, The Journal of comparative neurology.

[22]  J. Malpeli,et al.  Cat area 17. I. Pattern of thalamic control of cortical layers. , 1986, Journal of neurophysiology.

[23]  R. W. Guillery.  The laminar distribution of retinal fibers in the dorsal lateral geniculate nucleus of the cat: A new interpretation , 1970 .

[24]  R. D. Myers,et al.  Injection of solutions into cerebral tissue: Relation between volume and diffusion , 1966 .

[25]  T. Nealey,et al.  Magnocellular and parvocellular contributions to responses in the middle temporal visual area (MT) of the macaque monkey , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[26]  J. Malpeli,et al.  Thalamic control of cat area-18 supragranular layers: Simple cells, complex cells, and cells projecting to the lateral suprasylvian visual area , 1998, Visual Neuroscience.

[27]  J. Malpeli.  Activity of cells in area 17 of the cat in absence of input from layer a of lateral geniculate nucleus. , 1983, Journal of neurophysiology.

[28]  Somata-selective lesions induced by cobaltous chloride: A parametric study , 1986, Brain Research.