Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.

[1]  Jin Kwan Kim,et al.  Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. , 2005, Journal of medicinal chemistry.

[2]  N. Chen,et al.  Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. , 2005, Journal of medicinal chemistry.

[3]  A. Gomtsyan,et al.  Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. , 2005, Journal of medicinal chemistry.

[4]  A. Szallasi,et al.  Biochemical pharmacology of the vanilloid receptor TRPV1 , 2004 .

[5]  A. Szallasi,et al.  Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse? , 2004, Journal of medicinal chemistry.

[6]  P. Honore,et al.  TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics , 2002, Pain.

[7]  S. Bingham,et al.  Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia , 2000, Nature.

[8]  A I Basbaum,et al.  Impaired nociception and pain sensation in mice lacking the capsaicin receptor. , 2000, Science.

[9]  D. Julius,et al.  Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide , 1999, Nature.

[10]  P. Blumberg,et al.  Vanilloid (Capsaicin) receptors and mechanisms. , 1999, Pharmacological reviews.

[11]  A. Basbaum,et al.  The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli , 1998, Neuron.

[12]  D. Julius,et al.  The capsaicin receptor: a heat-activated ion channel in the pain pathway , 1997, Nature.

[13]  Shi-hui Wu,et al.  The Novel Reduction Systems: NaBH4-SbCl3 OR NaBH4-BiCl3 for Conversion of Nitroarenes to Primary Amines , 1995 .

[14]  A. Dray.  Inflammatory mediators of pain. , 1995, British journal of anaesthesia.

[15]  A. Furst,et al.  Conformationally restricted C-terminal peptides of substance P. Synthesis, mass spectral analysis and pharmacological properties. , 1985, Journal of medicinal chemistry.

[16]  R. Wrigglesworth,et al.  CAPSAICIN-LIKE AGONISTS , 1998 .